The development of highly expandable sponges for non-compressible hemorrhage remains a challenge in both civilian and war scenarios. Herein, a cellulose-based highly expandable sponge with arch-like lamellar structure was prepared by introducing interlayer calcium ion cross-linking in the sponges obtained by bi-directional freezing. The cellulose sponge, which has an arched layered structure that can withstand large stress strain, is compressed into small sizes to enter narrow and deep bleeding points, and then expand about 11 times after liquid absorption to apply sufficient and constant pressure on the bleeding points.
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