Background And Aims: Adolescent major depressive disorder (MDD) is prevalent globally but often goes unnoticed due to differences in symptoms compared to adult criteria. Analyzing the brain from a network perspective provides new insights into higher-level brain functions and its pathophysiology. This study aimed to investigate changes in the topological organization of functional networks in adolescents with first-episode, treatment-naïve MDD.
View Article and Find Full Text PDFBrain function relies on efficient communications between distinct brain systems. The pathology of major depressive disorder (MDD) damages functional brain networks, resulting in cognitive impairment. Here, we reviewed the associations between brain functional connectome changes and MDD pathogenesis.
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