Efficacy of fractional laser combined with bipolar radiofrequency in the treatment of atrophic facial acne scaring.

Objective: To evaluate the clinical efficacy of fractional laser treatment combined with bipolar radiofrequency for improving atrophic facial acne scars.

Methods: The clinical data of patients with atrophic facial acne scars treated in the Dermatology Department of The People's Hospital of Chongqing Liangping District from October 2022 to 2023 were retrospectively analyzed. The patients were divided into two groups based on treatment methods: the single intervention group (Group A, n=25) and the combined intervention group (Group B, n=25).

MiR-26b inhibits melanoma cell proliferation and enhances apoptosis by suppressing TRAF5-mediated MAPK activation.

Alterations in microRNA-26b (miR-26b) expression have been shown to participate in various malignant tumor developments. However, the possible function of miR-26b in human melanoma cells remains unclarified. In this study, quantitative polymerase chain reaction was used to explore the expression profiles of miR-26b in melanoma cells.

Short-term clinical effects of photodynamic therapy with topical 5-aminolevulinic acid for facial acne conglobata: an open, prospective, parallel-arm trial.

Background: Acne conglobata is hardly curable and easily leads to scar formation after treatment using traditional methods.

Aim: To develop a novel way to treat acne conglobata.

Methods: Seventy-five patients with facial acne conglobata were included in this clinical study and divided into either a treatment group (n = 35) to receive photodynamic therapy (PDT) with topical 5% 5-aminolevulinic acid and red light once every 10 days for a month or a control group (n = 40) to receive a Chinese herbal medicine mask plus red light once per week for the same duration.

Stepwise identification of HLA-A*0201-restricted CD8+ T-cell epitope peptides from herpes simplex virus type 1 genome boosted by a StepRank scheme.

Identification of immunodominant epitopes is the first step in the rational design of peptide vaccines aimed at T-cell immunity. To date, however, it is yet a great challenge for accurately predicting the potent epitope peptides from a pool of large-scale candidates with an efficient manner. In this study, a method that we named StepRank has been developed for the reliable and rapid prediction of binding capabilities/affinities between proteins and genome-wide peptides.