PYCR1 promotes liver cancer cell growth and metastasis by regulating IRS1 expression through lactylation modification.

Background: Liver cancer (LC) is among the deadliest cancers worldwide, with existing treatments showing limited efficacy. This study aimed to elucidate the role and underlying mechanisms of pyrroline-5-carboxylate reductase 1 (PYCR1) as a potential therapeutic target in LC.

Methods: Immunohistochemistry and Western blot were used to analyse the expression of PYCR1 in LC cells and tissues.