Yolk-shell structured nanoreactor Au@CoO/CeO@mSiO with superior peroxidase-like activity as nanozyme for ultra-sensitive colorimetric biosensing.

For yolk-shell structured nanoreactors, multiple active components can be precisely positioned on core and/or shell that can afford more exposed accessible active sites, and the internal voids can guarantee sufficient contact of reactants and catalysts. In this work, a unique yolk-shell structured nanoreactor Au@CoO/CeO@mSiO was fabricated and applied as nanozyme for biosensing. The Au@CoO/CeO@mSiO exhibited superior peroxidase-like activity with a lower Michaelis constant (K) and a higher affinity to HO.