Publications by authors named "Chaolu Hasi"
Siglec-9 is a promising immune checkpoint molecule, and therapeutics targeting Siglec-9 have the potential to augment anti-tumor immunity. Here, we generated a bispecific antibody, named as aSE4-1-Fc, by fusing two distinct alpaca derived nanobodies, which can simultaneously target the extracellular Ig variable (V)-set domain and C2-set domains of murine Siglec-9 (also known as Siglec-E) with high affinity. In vivo studies showed that aSE4-1-Fc was better than its component antibodies in inhibiting tumor growth/metastasis, and Siglec-E blockade using aSE4-1-Fc generated protective anti-tumor T cell memory.
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- This study investigates the characteristics and azole resistance mechanisms of Candida parapsilosis isolates in China.
- Out of 2318 isolates tested, 2.4% were resistant to fluconazole, especially prevalent among ICU patients, highlighting significant genetic clustering and transmission.
- Key mutations were identified, including Erg11Y132F, which contributes to resistance, along with others that play a role in increasing resistance levels and cross-resistance to different azoles.
Article Synopsis
- The study evaluates the diagnostic accuracy of prostate health index (PHI), prostate health index density (PHID), and percentage free prostate-specific antigen (%fPSA) for identifying clinically significant prostate cancer (csPCa) in patients with PSA levels above 4 ng/mL, particularly those in the "gray zone" (4-10 ng/mL).
- It prospectively analyzed serum samples and clinicopathological data from 296 patients who underwent prostate biopsies, focusing on those with Gleason scores indicative of csPCa.
- Results revealed that both PHID and PHI showed superior diagnostic performance (AUC: 0.880 and 0.867) compared to %fPSA, especially in patients
Diagnostic Role of NT-proBNP in Patients with Cardiac Amyloidosis Involvement: A Meta-Analysis.
Arq Bras Cardiol
August 2022
Background: Amyloidosis is defined as a disorder characterized by the deposition of extracellular protein material of amyloid in tissues.
Objectives: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is used to predict the cardiac amyloidosis (CA), but its diagnostic effect on CA involvement remains unclear, especially in terms of specificity and sensitivity.
Methods: A search for literature was conducted in the Pubmed, Embase, and Cochrane library databases, and QUADAS 2 was used for quality assessment.
Objective: This study was designed to explore the clinical characteristics, outcomes, and related influencing factors for asymptomatic patients with positive Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-Cov-2) nucleic acid test.
Methods: Clinical data of 1568 patients with positive SARS-Cov-2 nucleic acid test (SNAT) were collected retrospectively. The patients were assigned to an asymptomatic group and a symptomatic group according to the existence of clinical symptoms when they got positive result in nucleic acid test, and the clinical data of the two groups were analyzed and compared.
Article Synopsis
- The study analyzed the COVID-19 epidemic using a Markov model and examined clinical risk factors in 500 patients from X hospital during early 2020, categorizing them into general and acute critical groups.
- Results indicated that patients typically required about 14 days for infection recovery, with significant differences in complications like age, gender, and pre-existing health conditions between the two groups.
- The research concluded that the Markov model is useful for assessing the time course of COVID-19, highlighting the importance of prevention and treatment strategies to enhance patient outcomes and quality of life.