Publications by authors named "Chaoling Wang"

Background: Metabolic Score for Visceral Fat (METS-VF) is a novel indicator for estimating intra-abdominal fat, yet its connection with coronary artery calcification (CAC) remains uncharted. Our research aims to explore the novel METS-VF indicator's link to CAC while comparing its performance against relevant anthropometric indices.

Methods: This study enrolled participants who underwent health checkups and computed tomography scans for categorizing severity of CAC using the coronary artery calcium score.

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Background And Aim: The COVID-19 pandemic has led to a significant adverse effect on the mental health of healthcare professionals. This study aims to assess the effects of the prolonged pandemic on burnout and mood disorders and to evaluate the influence of positive vaccination beliefs on these factors at a medical center during the extended COVID-19 pandemic.

Methods: This retrospective study analyzed the results of an online questionnaire survey including burnout status and mood disorders from 2020 to 2022.

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Background And Aims: It is currently unclear whether the nonalcoholic fatty liver disease (NAFLD) fibrosis score, when compared to major anthropometric indices, is useful in estimating the risk of atherosclerotic cardiovascular disease (ASCVD).

Methods And Results: This study included 3886 adults undergoing a health checkup. An elevated risk of ASCVD was determined as a 10-year ASCVD risk ≥7.

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The controlled attenuation parameter (CAP) measurement obtained from FibroScan is a low-risk method of assessing fatty liver. This study investigated the association between the FibroScan CAP values and nine anthropometric indicators, including the abdominal volume index (AVI), body fat percentage (BFP), body mass index (BMI), conicity index (CI), ponderal index (PI), relative fat mass (RFM), waist circumference (WC), waist-hip ratio (WHR), and waist-to-height ratio (WHtR), and risk of non-alcoholic fatty liver disease (fatty liver). We analyzed the medical records of adult patients who had FibroScan CAP results.

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Article Synopsis
  • * Results indicated that HBsAg positivity was under 1% for those born after 1991, while HBV carriers showed elevated liver enzyme levels (ALT, AST) and lower body mass index (BMI) compared to non-carriers.
  • * A decline in anti-HBs positivity was noted, with plasma-derived vaccines showing better outcomes than recombinant vaccines; HBsAg presence was linked to higher likelihood of abnormal ALT levels.
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Shift work (SW) is the main working schedule worldwide, and it may cause sleep disorders, breast cancer, and cardiovascular disease. Low back pain (LBP) is a common problem in the workplace; however, the association between LBP and SW remains unclear. Therefore, we conducted a meta-analysis to determine the association between SW and LBP.

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Article Synopsis
  • This study aimed to investigate the relationship between secondhand smoke (SHS) exposure and peripheral arterial disease (PAD) due to conflicting results in previous research.
  • A meta-analysis included six studies, revealing a significant association between SHS and PAD, particularly highlighting a strong correlation for SHS exposure at home but not at work.
  • The findings suggest that being around secondhand smoke increases the risk of developing PAD, emphasizing the need for awareness and prevention, especially in home environments.
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Objectives: This study was conducted to explore the association between pneumoconiosis and pneumothorax.

Design: Retrospective cohort study.

Setting: Nationwide population-based study using the Taiwan National Health Insurance Database.

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The coronavirus disease 2019 (COVID-19) pandemic results in a profound physical and mental burden on healthcare professionals. This study aims to evaluate burnout status and mood disorder of healthcare workers during this period. An online questionnaire was voluntarily answered by eligible adult employees in a COVID-19 specialized medical center.

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Article Synopsis
  • This study investigated various cardiometabolic indices to determine their effectiveness in estimating atherosclerotic cardiovascular disease (ASCVD) risk among 3,143 Taiwanese adults aged 20-79 years.
  • Elevated ASCVD risk was defined as a 10-year risk of ≥7.5%, and the performance of different indices was evaluated using receiver operating characteristic (ROC) curves.
  • The Chinese visceral adiposity index (CVAI) showed the best performance in predicting ASCVD risk, particularly with the highest area under the curve for both genders, while traditional measures like BMI performed less effectively.
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Objectives: Occupational characteristics in the food and beverage service industry (FBSI) have been found to be associated with musculoskeletal disorders (MSDs). This study aimed to examine gender and site-specific incident risks of MSDs among FBSI workers in Taiwan using a national population-based database.

Methods: We conducted a 15-year population-based cohort study among 224 506 FBSI workers in Taiwan using data from five large nationwide databases to estimate direct standardized incidence ratios (SIRs) for identifying specific MSDs related to overexertion and repetitiveness during work.

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Objectives: Work is often a barrier for women to continue breastfeeding after they have given birth. Breastfeeding support is an important part of workplace health promotion. We investigated the implementation of breastfeeding promotion and gender equality polices in workplaces with the Taiwan Badge of Accredited Healthy Workplace.

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Background: Lead inhibits the enzymes in heme biosynthesis, mainly reducing δ-aminolevulinic acid dehydratase (ALAD) activity, which could be an available biomarker. The aim of this study was to detect the threshold of δ-aminolevulinic acid dehydratase activity reduced by lead exposure.

Methods: We collected data on 121 lead workers and 117 non-exposed workers when annual health examinations were performed.

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Metallothionein (MT) is a protein with function of heavy metal detoxification. However, studies about how single nucleotide polymorphisms (SNPs) of MT genes influence lead nephropathy are relatively scarce. Therefore, our aim is to investigate the association between blood lead levels and renal biomarkers and to study whether this association is influenced by the combination of MT1A and MT2A SNPs.

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Background/purpose: Chronic kidney disease (CKD) has become a worldwide health problem, leading to high morbidity and mortality, and non-alcoholic fatty liver disease (NAFLD) is considered a risk factor for CKD. The aim of this study was to explore the relationship between NAFLD fibrosis score (NFS) and the estimated glomerular filtration rate (eGFR), and identify possible risk factors related to the NFS among Taiwanese subjects.

Methods: Subjects were enrolled from the database of the Department of Preventive Medicine of Kaohsiung Municipal Hsiao-Kang Hospital.

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Research has shown that long-term exposure to lead harms the hematological system. The homeostatic iron regulator (hemochromatosis) mutation, which has been shown to affect iron absorption and iron overload, is hypothesized to be related to lead intoxication in vulnerable individuals. The aim of our study was to investigate whether the genotype modifies the blood lead levels that affect the distributions of serum iron and other red blood cell indices.

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Background: Lead (Pb), cadmium (Cd), and arsenic (As) could cause health issues through oxidative stress that is indicated in the elevated tumor necrosis factor-alpha (TNF-α). However, some of the essential elements-selenium (Se), zinc (Zn), cobalt (Co), and copper (Cu)-are cofactors or structural components of antioxidant enzymes. It is suggested that single-nucleotide polymorphisms (SNPs) in the TNF-α gene have different TNF-α responses.

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Background: The aim of this study was to ascertain the relationships of blood pressure, fasting sugar level, triglyceride (TG) level, uric acid level, and body mass index (BMI) with proteinuria and the estimated glomerular filtration rate (eGFR) in a population from southern Taiwan.

Methods: The 20,900 subjects enrolled in this study had undergone a free adult health examination under the National Health Insurance scheme between September 2005 and June 2011. Factors such as blood pressure, blood sugar, TG, uric acid and BMI were examined in terms of their relationships with the eGFR (calculated according to the Taiwanese Modification of Diet in Renal Disease (Taiwanese-MDRD)) and proteinuria.

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Background: n-Hexane is a well-known neurotoxicant. Polyneuropathy due to occupational n-hexane exposure has been reported worldwide, however, our case is the first report in the Chinese herb industry.

Case Presentation: A 25-year-old Asian man experienced progressive weakness and numbness in his hands and feet after working as an operator in a Chinese medicine pharmaceutical plant for the manufacture of Chinese herbal pain relief patches for 10 months.

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Background: Lead in blood can stimulate lipid oxidation in phosphatidylcholine and increase peroxidation in lipids. Metallothionein (MT) is a cysteine-rich protein that can influence the detoxification of heavy metals and scavenge oxidative stress for free radicals. One of the most expressive functional genes in humans is the MT2A gene.

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Chronic infection by hepatitis C virus (HCV) is a major risk factor for the development of hepatocellular carcinoma (HCC). Despite the clear clinical importance of virus-associated HCC, the underlying molecular mechanisms remain largely unclarified. Oxidative stress, in particular, DNA lesions associated with oxidative damage, plays a major role in carcinogenesis, and is strongly linked to the development of many cancers, including HCC.

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Objective: To determine the association between the severity of femoral condylar cartilage erosion resulting from knee osteoarthritis (OA) by an ultrasonographic grading system and the clinical symptoms and functions.

Design: Cross-sectional study.

Setting: A tertiary center.

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Objective: In this study, we conducted a questionnaire-based survey at Sichuan University to investigate the potential effects of bedtime on recurrent aphthous stomatitis (RAS).

Study Design: An anonymous self-designed questionnaire was adopted to investigate the association between bedtime and RAS in college students at Sichuan University. Statistical analyses were used to identify risk factors for RAS and to explore the relationship between bedtime and RAS.

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Several studies have found that metabolic syndrome and uric acid level are related to abnormal liver function test results. The aim of this study was to explore the associations of risk factors [including blood pressure, blood sugar, total cholesterol, triglyceride, uric acid, waist circumference and body mass index (BMI) measurements] with abnormal liver function in the Taiwanese population.In total, 11,411 Taiwanese adults were enrolled in this study.

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