Publications by authors named "Chaoling Peng"
Solute carrier 25 member 21 () serves as an oxodicarboxylate carrier, which mainly conveys 2-oxoadipate from the cytoplasm to the mitochondria a reverse exchange mechanism. Previous studies have indicated that the capacity for glucose consumption is significantly enhanced in 3T3-L1 cells overexpressing . In this study, we upregulate in 3T3-L1 cells to further probe into the downstream key metabolic genes of .
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- Obesity raises the levels of a fat called palmitic acid (PA), which causes special stress pathways in fat cells to turn on.
- This study found that when these pathways are activated, more tiny molecules called miRNAs get released into the body.
- Blocking these pathways in experiments helped lower miRNA levels and improved things like blood sugar and insulin sensitivity in obese mice.
Objective: In our previous study, we identified a notable increase in miR-548ag content after obesity, which contributes to the progression of Type 2 diabetes Mellitus(T2DM) through the up-regulation of Dipeptidyl Peptidase-4(DPP4) expression within the liver. However, the precise molecular mechanisms underlying the upregulation of DPP4 by miR-548ag remain elusive. Mature miRNAs rich in GU sequences can activate the TLR(7/8)/NF-κB signalling pathway, which transcriptionally activates DPP4 expression.
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