Background And Objectives: Gemcitabine plus cisplatin (GP) and docetaxel plus cisplatin plus fluorouracil (TPF) are induction chemotherapy (IC) regimens for locally advanced nasopharyngeal carcinoma (LA-NPC). The oral convenience of capecitabine presents its potential as a fluorouracil substitute in the TPF regimen, which has yet to be thoroughly investigated. This study aims to compare the efficacy and safety of the docetaxel, cisplatin, and capecitabine (TPC) with GP and TPF in LA-NPC.
View Article and Find Full Text PDFThe uncontrolled release of antibiotics into the environment would be extremely harmful to human health and ecosystems. Therefore, it is in urgent need to monitor the environment and promote the detection and degradation of antibiotics to the relatively harmless by-products to a feasible extent. Graphitic carbon nitride (g-CN) is a non-metallic n-type semiconductor that can be used for the antibiotic detection and degradation due to its easy synthesis process, excellent chemical stability and unique optical properties.
View Article and Find Full Text PDFUltrason Sonochem
November 2024
Based on sonochemistry, green synthesis methods play an important role in the development of nanomaterials. In this work, a novel chitosan modified MnMoO/g-CN (MnMoO/g-CN/CHIT) was developed using ultrasonic cell disruptor (500 W, 30 kHz) for ultra-sensitive electrochemical detection of tinidazole (TNZ) in the environment. The morphology and surface properties of the synthesized MnMoO/g-CN/CHIT electrode were characterized using X-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and transmission electron microscope (TEM).
View Article and Find Full Text PDFIn order to ensure the filling integrity of complex counter-gravity casting and improve metallurgical quality, it is necessary to shorten the filling time while avoiding air entrainments. To address this contradiction, a novel nonlinear pressurization method was proposed in this study. Through systematically analyzing the relationship between critical gating velocity and stable filling height, a criterion for iterative calculation of nonlinear pressurization curve was established, and an empirical expression between nonlinear pressurizing speed and the filling height was obtained.
View Article and Find Full Text PDFFunctional brain networks (FBNs), which are used to portray interactions between different brain regions, have been widely used to identify potential biomarkers of neurological and mental disorders. The FBNs estimated using current methods tend to be homogeneous, indicating that different brain regions exhibit the same type of correlation. This homogeneity limits our ability to accurately encode complex interactions within the brain.
View Article and Find Full Text PDFBackground: Colorectal cancer (CRC) remains a major global health challenge, with high incidence and mortality rates. The role of long noncoding RNAs (lncRNAs) in cancer progression has received considerable attention. The present study aimed to investigate the function and mechanisms underlying the role of lncRNA RP11-197K6.
View Article and Find Full Text PDFExtended-spectrum-β-lactamases (ESBLs)-producing Escherichia coli conferred resistance to most β-lactams, except for carbapenems. To date, the transmission mechanism of bla, as the most common ESBLs subtype, in E. coli has received sustained attention around the worldwide, but the research on the pathogenicity of bla-bearing E.
View Article and Find Full Text PDFTo find the predictors of early HCC based on the dynamic changes of HBV quasispecies, this study utilizing the second-generation sequencing (NGS) and high-order multiplex droplet digital PCR (ddPCR) technology to examine the HBV quasispecies in serum of total 247 subjects recruited from high-incidence area of HCC. In the discovery stage, 15 non-synonymous Single Nucleotide Polymorphisms (SNPs) with higher variant proportion in HCC case group were founded (all P<0.05).
View Article and Find Full Text PDFCurr Issues Mol Biol
November 2023
Chaylte vine, the tender shoot of , is popular among vegetable consumers because of its high nutritional content, crisp texture, and unique flavor. Existing studies on the nutrient composition of chaylte vines are mostly simple chemical determinations, which have limited the breeding of specialized cultivars and the development of related industries. Using metabolomics combined with transcriptomics, this study analyzed the metabolic characteristics and related molecular mechanisms of two common varieties of chaylte vines: green-skinned (SG) and white-skinned (SW).
View Article and Find Full Text PDFTo explore the prognostic value of clinical and serological risk factors for progression-free survival (PFS) in stage II and T3N0 nasopharyngeal carcinoma (NPC) and construct a nomogram based on these factors. Additionally, to investigate the long-term survival and short-term toxic reactions of patients in different risk stratification under different treatment modalities. The patients were randomly divided into training and validation cohorts in a 7:3 ratio.
View Article and Find Full Text PDFEthnopharmacological Relevance: Coix lacryma-jobi var. ma-yuen (Romanet du Caillaud) Stapf is a plant of the genus Coix in the Gramineae family. Coix seed is cultivated in various regions throughout China.
View Article and Find Full Text PDFIntroduction: The most common intrathoracic anastomosis techniques for Siewert type II adenocarcinoma of the esophagogastric junction (AEG) are the overlap and transorally inserted anvil (OrVil) methods. However, the criteria for choosing between these two methods require further study.
Aim: This retrospective study aimed to compare the efficacy and safety of overlap versus OrVil anastomosis in transabdominal radical surgery for Siewert type II adenocarcinoma of the esophagogastric junction.
IEEE Trans Neural Syst Rehabil Eng
September 2023
Resting-state functional magnetic resonance imaging (rs-fMRI) has been widely used in the detection of brain disorders such as autism spectrum disorder based on various machine/deep learning techniques. Learning-based methods typically rely on functional connectivity networks (FCNs) derived from blood-oxygen-level-dependent time series of rs-fMRI data to capture interactions between brain regions-of-interest (ROIs). Graph neural networks have been recently used to extract fMRI features from graph-structured FCNs, but cannot effectively characterize spatiotemporal dynamics of FCNs, e.
View Article and Find Full Text PDFFunctional connectivity network (FCN) has become a popular tool to identify potential biomarkers for brain dysfunction, such as autism spectrum disorder (ASD). Due to its importance, researchers have proposed many methods to estimate FCNs from resting-state functional MRI (rs-fMRI) data. However, the existing FCN estimation methods usually only capture a single relationship between brain regions of interest (ROIs), e.
View Article and Find Full Text PDFThe inadequacy of the existing research in characterizing the atomization performance of the whole atomization field by the local region at nozzle axis hinders the improvement of dust removal performance of a spray system, especially for fan-shaped nozzles with large atomization angle. To solve this inadequacy, 88 measuring points were designed in this study to reveal the spatial distribution characteristics of atomization parameters of a fan-shaped pressure atomization nozzle using a 3D Fiber Phase-Doppler Anemometer. Moreover, the atomization performance and dust removal performance of the whole atomization field under different spray pressures were characterized.
View Article and Find Full Text PDFIntestinal ischemia-reperfusion (I/R) injury is a common pathophysiological process in various diseases, and the disruption of the intestinal barrier composed of tight junction proteins is the initiating factor, which then leads to a large number of bacteria and endotoxins in the intestine into the bloodstream causing stress and distant organ damage. The release of inflammatory mediators and abnormal programmed death of intestinal epithelial cells are important factors of intestinal barrier damage. Succinate is an intermediate product of the tricarboxylic acid cycle with anti-inflammatory and pro-angiogenic activities, but its role in the maintenance of intestinal barrier homeostasis after I/R has not been fully elucidated.
View Article and Find Full Text PDFIdentifying the stability and phytotoxicity of liquid digestate (LD) is necessary for safe agricultural utilization. Storage temperature, method, and time are critical factors that affect the stability and phytotoxicity of LD. This study therefore aimed to explore the dynamics of stability, phytotoxicity, and microbial community of LD in cattle farms under different storage conditions.
View Article and Find Full Text PDFBackground: Microcystin-LR (MC-LR) and hepatitis B virus (HBV) are associated with hepatocellular carcinoma (HCC). However, the concentrations of MC-LR in drinking water and the synergistic effect of MC-LR and HBV on hepatocellular carcinogenesis through their disturbance of redox balance have not been fully elucidated.
Methods: We measured the MC-LR concentrations in 168 drinking water samples of areas with a high incidence of HCC.
Gastric cancer (GC) was the fourth deadliest cancer in the world in 2020, and about 770,000 people died from GC that year. The death of patients with GC is mainly caused by the metastasis, recurrence, and chemotherapy resistance of GC cells. The cancer stem cell theory defines cancer stem cells (CSCs) as a key factor in the metastasis, recurrence, and chemotherapy resistance of cancer.
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