Analysis of the spatial and temporal evolution of drought in Henan based on a nonlinear composite drought index.

It is of practical significance to provide a reference for drought mitigation and water resource enhancement planning in the Henan Province region and to analyze the spatial and temporal evolution characteristics of meteorological agricultural drought in the region. In this study, a multivariate (precipitation, potential evapotranspiration, soil moisture and normalized vegetation index) composite drought index CCDI was constructed based on the D Vine copula model, and the correlations between the CCDI and the standardized precipitation evapotranspiration index (SPEI) and between the CCDI and the standardized soil moisture index (SSI) were analyzed. The ability of the CCDI to evaluate meteorological agricultural drought was assessed, and typical drought events were selected for validation.

Identification of m7G-associated lncRNA prognostic signature for predicting the immune status in cutaneous melanoma.

RNA modifications, including RNA methylation, are widely existed in cutaneous melanoma (CM). Among epigenetic modifications, N7-methylguanosine (m7G) is a kind of modification at 5' cap of RNA which participate in maintaining the stability of mRNA and various cell biological processes. However, there is still no study concerning the relationship between CM and m7G methylation complexes, METTL1 and WDR4.

Exosome miR-23a-3p from Osteoblast Alleviates Spinal Cord Ischemia/Reperfusion Injury by Down-Regulating KLF3-Activated CCNL2 Transcription.

Background: Spinal cord ischemia/reperfusion injury (SCIRI) is usually caused by spinal surgery or aortic aneurysm surgery and can eventually lead to paralysis or paraplegia and neurological dysfunction. Exosomes are considered as one of the most promising therapeutic strategies for SCIRI as they can pass the blood-spinal barrier. Previous studies have proved that exosomes secreted by osteocytes have a certain slowing effect on SCIRI.

A novel pyroptosis-associated gene signature for immune status and prognosis of cutaneous melanoma.

Background: Cutaneous melanoma (CM) is a life-threatening destructive malignancy. Pyroptosis significantly correlates with programmed tumor cell death and its microenvironment through active host-tumor crosstalk. However, the prognostic value of pyroptosis-associated gene signatures in CM remains unclear.