Comparison of lidocaine bicarbonate with fentanyl and chloroprocaine for epidural anesthesia during cesarean section: a randomized, controlled, double-blind clinical trial.

Chloroprocaine and lidocaine bicarbonate are commonly used for epidural anesthesia because of their rapid onset, particularly in the case of conversion from epidural labor analgesia to emergency cesarean section. However, it is unclear whether lidocaine bicarbonate combined with fentanyl has an advantage over chloroprocaine alone in emergency cesarean section. In this study, 102 women who underwent elective cesarean section received 15 mL 3% chloroprocaine and 1 mL saline (CP group) or 15 mL 1.

Clinical efficacy of laparoscopic cholecystectomy plus cholangioscopy for the treatment of cholecystolithiasis combined with choledocholithiasis.

Background: Currently, endoscopic retrograde cholangiopancreatography (ERCP) plus laparoscopic cholecystectomy (LC) is the main treatment for cholecystolithiasis combined with choledocholithiasis. However, the treatment is unsatisfactory, and the development of better therapies is needed.

Aim: To determine the clinical efficacy of LC plus cholangioscopy for cholecystolithiasis combined with choledocholithiasis.

Progress of near-infrared-II fluorescence in precision diagnosis and treatment of colorectal cancer.

Colorectal cancer is a malignant tumour with high incidence and mortality worldwide; therefore, improving the early diagnosis of colorectal cancer and implementing a targeted "individualized treatment" strategy is of great concern. NIR-II fluorescence imaging is a large-depth, high-resolution optical bioimaging tool. Around the NIR-II window, researchers have developed a variety of luminescent probes, imaging systems, and treatment methods with colorectal cancer targeting capabilities, which can be visualized and image-guided in clinical surgery.

Efficacy and Safety of Esketamine for Supplemental Analgesia During Elective Cesarean Delivery: A Randomized Clinical Trial.

Importance: Epidural anesthesia is a primary choice for cesarean delivery, but supplemental analgesics are often required to relieve pain during uterine traction.

Objective: To investigate the sedative and analgesic effects of intravenous esketamine administered before childbirth via cesarean delivery with the patient under epidural anesthesia.

Design, Setting, And Participants: This multicenter, double-blind randomized clinical trial assessed 903 women 18 years or older who had full-term single pregnancy and were scheduled for elective cesarean delivery with epidural anesthesia in 5 medical centers in China from September 18, 2021, to September 20, 2022.

Integrative Nomogram of Computed Tomography Radiomics, Clinical, and Tumor Immune Features for Analysis of Disease-Free Survival of NSCLC Patients with Surgery.

To improve prognosis of cancer patients and determine the integrative value for analysis of disease-free survival prediction, a clinic investigation was performed involving with 146 non-small cell lung cancer (NSCLC) patients (83 men and 73 women; mean age: 60.24 years ± 8.637) with a history of surgery.

Construction of a Necroptosis-Associated Long Non-Coding RNA Signature to Predict Prognosis and Immune Response in Hepatocellular Carcinoma.

Necroptosis is a form of programmed cell death, and studies have shown that long non-coding RNA molecules (lncRNAs) can regulate the process of necroptosis in various cancers. We sought to screen lncRNAs associated with necroptosis to predict prognosis and tumor immune infiltration status in patients with hepatocellular carcinoma (HCC). Transcriptomic data from HCC tumor samples and normal tissues were extracted from The Cancer Genome Atlas database.

Iridescent Colloidal Crystals Composed of SiO Porous Hollow Sphere for SERS Application.

In recent years, the application of low-refractive-index materials in the optical field has attracted considerable attention due to it high transmittance and high optical sensitivity. In this study, we synthesized SiO porous hollow spheres (SPHS) with an ultralow refractive index ( = 1.05) by using a templating method.

Radiomics for differentiating minimally invasive adenocarcinoma from precursor lesions in pure ground-glass opacities on chest computed tomography.

Objective: To explore the correlation between radiomic features and the pathology of pure ground-glass opacities (pGGOs), we established a radiomics model for predicting the pathological subtypes of minimally invasive adenocarcinoma (MIA) and precursor lesions.

Methods: CT images of 1521 patients with lung adenocarcinoma or precursor lesions appearing as pGGOs on CT in our hospital (The Third Affiliated Hospital of Sun Yat-sen University) from January 2015 to March 2021 were analyzed retrospectively and selected based on inclusion and exclusion criteria. pGGOs were divided into an atypical adenomatous hyperplasia (AAH)/adenocarcinoma (AIS) group and an MIA group.

Cuprous oxide coated silver/graphitic carbon nitride/cadmium sulfide nanocomposite heterostructure: Specific recognition of carcinoembryonic antigen through sandwich-type mechanism.

The development of the effective diagnostic method for the determination of cancer biomarkers is one of the most promising strategies for early clinical diagnosis of cancer. Here, based on the preparation of heterogeneous cuprous oxide coated silver (Ag@CuO) nanocomposites/graphitic carbon nitride (g-CN)/cadmium sulfide (CdS) nanoarrays structure, a highly sensitive photoelectrochemical (PEC) biosensor for the examination of carcinoembryonic antigen (CEA) has been constructed successfully. The combination of photoactive semiconductor materials g-CN and CdS increases the electron transfer rate between them and enhances their photocurrent response, thus greatly increasing the concentration detection range.

Daphnetin inhibits the survival of hepatocellular carcinoma cells through regulating Wnt/β-catenin signaling pathway.

Evidence has demonstrated that Daphnetin has antiangiogenesis activity, indicating it might be a new multi-targeted medication for cancer therapy. Here, we aimed to reveal Daphnetin role in hepatocellular carcinoma (HCC) progression and the underlying mechanism. Huh7 and SK-HEP-1, two human HCC cell lines were used in this study.

Multifunctional CNTs-PAA/MIL101(Fe)@Pt Composite Membrane for High-throughput Oily Wastewater Remediation.

A surge of effort has been devoted to establishing super-wetting membranes with versatility for oily waste water purification. However, persistent challenge remains the lower separation flux. Moreover, the majorities of catalysts are only adsorbed on the surface and easily fall off after multiple cyclic separations.

Upconversion luminescence nanomaterials: A versatile platform for imaging, sensing, and therapy.

Upconversion luminescence is an optical process that emits high-energy photons by absorbing two or more low-energy photons, which is caused by anti-Stokes luminescence, has attracted significant attention in recent years. Upconversion nanomaterials are superior to quantum dots and organic dyes because of their unique properties, including non-photobleaching, non-blinking, low-toxicity, photostability, high conversion efficiency, high light penetration in biological tissues and long lifetime, from nanoseconds up to 6 orders of magnitude to milliseconds, which render them an ideal kind of fluorescent labels for a variety of analytical formats as well as bioimaging in cancer therapy, showing great potential for both in vitro and vivo imaging and biodetection assays applications. This paper will introduce upconversion luminescence nanomaterials from mechanisms composition and synthesis, moreover, we will also discuss recent progress regarding the applications of upconversion nanomaterials in sensing, imaging and therapy.

Experimental and theoretical studies of a novel electrochemical sensor based on molecularly imprinted polymer and B, N, F-CQDs/AgNPs for enhanced specific identification and dual signal amplification in highly selective and ultra-trace bisphenol S determination in plastic products.

As an ideal alternative to bisphenol A (BPA), bisphenol S (BPS) has similar biotoxicity, teratogenicity, carcinogenicity and mutagenicity as BPA. Nevertheless, to date, a fast, sensitive and portable method for meeting on-site measurement of BPS had not been established. Hence, it was particularly urged to develop a fast and highly sensitive method for tracing BPS.

Efficacy of Chaihu Jisang decoction on post-infection cough and its effect on cough reflex sensitivity.

Objective: To investigate the efficacy of Chaihu Ji Sang Decoction (CJSD), (a modification of Xiao Chaihu Tang (Minor Decoction of Bupleurum) was evaluated in patients with post-infection cough (PIC). Its effect on cough reflex sensitivity (CRS) was also described.

Methods: One hundred and eighteen patients with PIC were enrolled and randomly divided into an experimental group and control group (54 patients in each group).

Liver-enriched Genes are Associated with the Prognosis of Patients with Hepatocellular Carcinoma.

Tissue-enriched genes are highly expressed in one particular tissue type and represent distinct physiological processes. The dynamic profile of tissue-enriched genes during tumorigenesis and progression remains largely unstudied. Here, we identified tissue-enriched genes from 12 tissue types based on RNA sequencing data from the Cancer Genome Atlas (TCGA), and found that the liver had the largest number of such genes among the 12 tissue types.

Efficacy of Daily Low-dose Tadalafil for Treating Overactive Bladder: Results of a Randomized, Double-blind, Placebo-controlled Trial.

Objective: To evaluate the efficacy of daily low-dose tadalafil therapy for overactive bladder (OAB) in women.

Patients And Methods: A total of 96 women with idiopathic OAB from 3 medical centers in the south of Zhejiang Province of China were randomly assigned to treatment with daily low-dose tadalafil (5 mg, n = 48) or placebo (n = 48) for 3 months. The Indevus Urgency Severity Scale, overactive bladder symptom score (Homma et al, 2006), and a 3-day micturition diary with frequency, incontinence, and urgency episodes were recorded and compared before the treatment, every 2 weeks following the treatment, and 3 months after the treatment.

[A study on the differences of emotion and depression between patients as doctor/nurse and others occupation with severe acute respiratory syndrome].

Objective: To study the emotional and depressive differences between severe acute respiratory syndrome (SARS) patients whose occupations were doctor/nurse and others.

Methods: During the three months when SARS was explosive in 2003, 524 questionnaires were collected from Xuanwu Hospital, You'an Hospital, Xiaotangshan Hospital, Renmin Hospital and Ditan Hospital in Beijing. There were 109 questionnaires finished by patients as doctors/nurses themselves.