Publications by authors named "Chaohua Fang"

Article Synopsis
  • Recent advancements in biosensors using odorant-binding proteins (OBPs) allow for the detection of odorants and pheromones, though challenges remain in detecting aldehydes effectively.
  • A new OBP2a-based electrochemical impedance spectroscopy (EIS) biosensor was created, showing high sensitivity and selectivity for specific aldehydes while minimizing interference from other substances.
  • The biosensor demonstrated excellent repeatability, stability, and recovery rates, indicating its potential applications in medical diagnostics, food analysis, and environmental monitoring.
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Background: The present study aimed to identify the risk factors of periprosthetic femoral fracture (PFF) after cementless total hip arthroplasty and rank them based on importance.

Methods: The age, sex, body mass index (BMI), osteoporosis, canal flare index (CFI), canal bone ratio (CBR), canal calcar ratio (CCR), stem design, and stem canal fill ratio (P1, P2, P3, and P4) of the proximal femoral medullary cavity of 111 total hip arthroplasty patients who had PFF and 388 who did not have PFF were analyzed. Independent-samples student t-tests were used for continuous variables, and Chi-square tests were used for categorical variables.

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Component alignment is one of the most crucial factors affecting total knee arthroplasty's clinical outcome and survival. This study aimed to investigate how coronal, sagittal, and transverse malalignment affects the mechanical behavior of the tibial insert and to determine a suitable alignment tolerance on the coronal, sagittal, and transverse planes. A finite element model of a cruciate-retaining knee prosthesis was assembled with different joint alignments (-10°, -7°, -5°, -3°, 0°, 3°, 5°, 7°, 10°) to assess the effect of malalignment under gait loading.

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Article Synopsis
  • The study compares the component alignment and clinical outcomes of total knee arthroplasty (TKA) using three different surgical systems: conventional instrumentation (CONI), accelerometer-based navigation (ABN), and computer navigation (CN).
  • Meta-analyses of 18 studies for CONI and ABN, and 5 studies for ABN and CN revealed that the ABN system led to better alignment but took longer to perform than the CONI method, with no significant difference in postoperative clinical outcomes (PCO).
  • Overall, while the ABN system improved component alignment and reduced outliers, it required more surgical time compared to CONI, and there were no major differences in outcomes between
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Anterior cruciate ligament reconstruction (ACLR) using a generally columnar graft is considered the gold standard for treating anterior cruciate ligament ruptures, but such grafts cannot replicate the geometry and mechanical properties of the native anterior cruciate ligament. To evaluate the effectiveness of an innovative hourglass-shaped graft versus a traditional columnar graft for restoring joint stability and graft force, while avoiding notch impingement following anterior cruciate ligament reconstruction. Finite element models of a human knee were developed to simulate ① An intact state, ② anterior cruciate ligament reconstruction using columnar grafts with different diameters (7.

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Background: Stress shielding ​(SS) is considered the main mechanical cause of femoral stem loosening after total hip arthroplasty (THA). This study introduces an auxetic lattice femoral stem structure with negative Poisson's ratio that can expand laterally, with the intent of transferring more load to surrounding bone and thereby reducing SS. This study aims to evaluate how the geometry profile of different femoral stems with auxetic structures affects the level of SS.

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Objective: To investigate the effect of open wedge tibial high osteotomy on patella position, anterior knee pain and joint function.

Methods: From June 2016 to June 2021, 109 patients (111 knees) with medial knee osteoarthropathy treated by open wedge tibial high osteotomy were included according to the inclusion and exclusion criteria, including 41 males and 68 females;the age ranged from 38 to 78 years old with an average of(57.98±7.

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Article Synopsis
  • The study examined how the alignment of knee components affects the short-term clinical results in patients who underwent total knee arthroplasty (TKA).
  • 50 patients had their component alignments measured post-surgery, and their outcomes were assessed after one year using the Hospital for Special Surgery (HSS) knee scoring system.
  • Significant correlations were found between certain alignment measurements, particularly femoral flexion-extension angle (FEA), and various clinical outcomes, indicating that optimizing FEA could enhance TKA results.
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This study aimed to investigate the influence of tibial malrotation on knee kinematics after total knee arthroplasty (TKA). A symmetric fixed-bearing posterior-stabilized prosthesis was implanted in the validated knee model with different rotational alignments of the tibial component (neutral, 3° external rotation, 5° external rotation, 3° internal rotation, and 5° internal rotation). Computational kinematic simulations were used to evaluate the postoperative kinematics of the knee joint including anteroposterior translation femoral condyles and axial rotation of tibial component during 0°-135° knee flexion.

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Objective: Several needleless techniques have been developed to outcome the inherent disadvantages of the traditional needle stitching technique for graft preparation, such as tendon damage through the needle, time consumption, and the potential risk of needlestick injury. The purpose of the present study is to compare the graft preparation time and the biomechanical performance between an efficient needleless technique and the traditional needle stitching technique for graft preparation in anterior cruciate ligament reconstruction (ACLR).

Methods: The time required to perform a complete suture on 20 hamstring tendons during ACLRs was measured.

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Spinal cord injury (SCI) often involves multimodal pain control. This study aims to evaluate the efficacy and safety of cannabinoid use for the reduction of pain in SCI patients. This study followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement.

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Objectives: To find out the genetic association between IL6 and autoimmune arthritis.

Methods: We performed a two-sample Mendelian randomization (MR) study using multiple genome-wide association studies (GWAS) datasets. Furthermore, a sex-stratified MR study was performed to identify sexual dimorphism in the association between IL6 and autoimmune arthritis.

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Background: The interference screw is the most popular device that fixes the graft for anterior cruciate ligament reconstruction, reducing the incidence of windshield effect and bungee effect. For the screw, either metallic, "bioresorbable," or polyetheretherketone (PEEK) material is available. PEEK is popular and extensively used due to its stability, biocompatibility, radiolucency, and elastic modulus.

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Background: Arthroscopic surgery procedures vary depending on the types of meniscus tear, including meniscectomy and meniscus repair. Among the several types of meniscus tear, the horizontal tear of the lateral meniscus at the popliteal hiatus region is a common injury, and its surgical treatment is still inconsistent.

Methods: Between January 2018 and October 2018, 20 patients who underwent all-inside repair with suture hook for the horizontal tear of the lateral meniscus at the popliteal hiatus region were recruited.

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Rotational malalignment between the femoral and tibial components in total knee arthroplasty (TKA) can affect clinical outcomes, but there is no consensus on how to best determine tibia tray orientation. The posterolateral corner-locked (PLCL) technique may be a new method. This study aims to assess the applicability of this technique in a Chinese population.

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Background: Although thrombosis complication is rare after arthroscopic meniscus surgery, deep vein thrombosis and pulmonary embolism can be fatal. The associated risk factors and whether anticoagulant prevention after arthroscopic knee surgery is necessary have not reach consensus. Here we present a case of deep vein thrombosis and pulmonary embolism after a common arthroscopic meniscectomy.

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Purpose: Excellent clinical and kinematical performance is commonly reported after medial pivot knee arthroplasty. However, there is conflicting evidence as to whether the posterior cruciate ligament should be retained. This study simulated how the posterior cruciate ligament, post-cam mechanism and medial tibial insert morphology may affect postoperative kinematics.

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