Publications by authors named "Chaohong Cai"
Article Synopsis
- Paxlovid received emergency approval in China for COVID-19 treatment, but its effects on kidney transplant patients taking tacrolimus are not well-studied.
- Tacrolimus was stopped on the same day Paxlovid was administered, with close monitoring of tacrolimus and creatinine levels using EMIT and LC-MS/MS techniques.
- The study found that creatinine levels increased in three patients, and that EMIT might give higher readings of tacrolimus metabolites than LC-MS/MS; all findings followed ethical guidelines.
Purpose: To evaluate the bioequivalence and safety of two formulations of 25 mg tenofovir alafenamide tablets in Chinese healthy male and female subjects under fed and fasting conditions.
Patients And Methods: This was a randomized, open-label, single-center, crossover study consisting of a fasting trial with two periods and a fed trial with four periods. In total, 42 healthy subjects were enrolled in the fasting trial and 32 healthy subjects were enrolled in the fed trial.
Objective: Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in substantia nigra (SN). Our previous study demonstrated kukoamine A (KuA) to exhibit strong neuroprotective effects through antioxidative stress, and autophagy in MPTP/MPP-induced PD models and . It is necessary to evaluate the efficacy of the anti-PD effects under various models.
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