Anti-Inflammatory and Antioxidative -Acetyldopamine Dimers from Adult Smith.

One undescribed fatty glyceride (), two unreported -acetyldopamine dimers ( and ), and four known structurally diverse -acetyldopamine dimers were isolated from adult Smith. Their structures were elucidated based on a comprehensive analysis of spectroscopic data, HRESIMS, and NMR calculations with ML_J_DP4, and the absolute configurations of and were determined via ECD calculations. Regarding their bioactivities, compounds and can inhibit the production of NO.

Proliferation Inhibitory Activity of Quinones from Blaps rynchopetera Defense Secretion on Colorectal Tumor Cells.

Objective: To explore the proliferation inhibitory effect of quinones from Blaps rynchopetera defense secretion on colorectal tumor cell lines.

Methods: Human colorectal cancer cell HT-29, human colorectal adenocarcinoma cell Caco-2 and normal human colon epithelial cell CCD841 were chosen for the evaluation of inhibitory activity of the main quinones of B. rynchopetera defense secretion, including methyl p-benzoquinone (MBQ), ethyl p-benzoquinone (EBQ), and methyl hydroquinone (MHQ), through methyl thiazolyl tetrazolium assay.

The Regulating Effect of CII-3 and Its Active Components from on M1/M2 Macrophage Polarization.

CII-3 is the effective part of for application in oncotherapy. This study investigated its main chemical components for macrophage polarization regulation activity. Compounds were separated and purified, and their structures were elucidated based on NMR and HR-ESI-MS analyses.