Performance of the Cement Grouting Material and Optimization of the Mix Proportion for the Free Section of the Prestressed Anchor Bar.

Increasing the water-cement ratio and water-reducer dosage of cement slurry enhances its fluidity. However, a high water-cement ratio diminishes the beneficial effects of water reducers on fluidity. The stone content of the slurry decreases as the water-reducer dosage increases.

Overexpressed Thrombospondin 2 Induced Osteogenic Differentiation of Valve Interstitial Cells via Inhibition of Akt/NF-B Signaling Pathway to Promote Calcific Aortic Valve Disease Development.

Thrombospondin 2 (THBS2) is reported to participate in the development of calcific aortic valve disease (CAVD), while the effects are not elucidated completely. The study aimed to explore the role and mechanism of THBS2 in CAVD. Differentially expressed genes related to stenosis and sclerosis were screened through Limma package based on data from Gene Expression Omnibus (GEO), and the functional enrichment analysis was performed by the Database for Annotation, Visualization and Integrated Discovery (DAVID) database.

CircRNA TGFBR2/MiR-25-3p/TWIST1 axis regulates osteoblast differentiation of human aortic valve interstitial cells.

Introduction: Calcified aortic valve disease (CAVD) is characterized by valve thickening and calcification. Osteoblast differentiation is one of the key steps of valve calcification. CircRNAs is involved in osteogenic differentiation of multiple mesenchymal cells.