Publications by authors named "ChaoLin Huang"
Objective: This study aimed to investigate the clinical significance of heat shock protein 60 (HSP60) expression in ovarian cancer and evaluate its correlation with patient survival outcomes.
Methods: A total of 260 ovarian cancer patients diagnosed between 2017 and 2019 were enrolled. Immunohistochemistry was performed to assess HSP60 expression in tumor tissues.
In the post-pandemic era, research on respiratory diseases should refocus on pathogens other than the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Respiratory pathogens, highly infectious to children, with to different modes of infection, such as single-pathogen infections and co-infections. Understanding the seasonal patterns of these pathogens, alongside identifying single infections and co-infections and their impact on the pediatric immune status, is crucial for clinical diagnosis, treatment, and prognosis in children.
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- Polycystic ovary syndrome (PCOS) affects 8-13% of women in their reproductive years and is commonly treated with off-label drugs that can have side effects; this study investigates curcumin's therapeutic effects in a PCOS rat model.
- The PCOS model was created using dehydroepiandrosterone (DHEA), followed by curcumin treatment, which assessed changes in ovarian morphology, hormone levels, and oxidative stress markers.
- Results showed that curcumin improved hormone levels, restored normal ovarian function, and reduced oxidative stress, suggesting its potential as a treatment for PCOS by enhancing PPAR-γ levels.
Background And Objectives: The high costs associated with biological agents often limit accessibility for many patients, whereas biosimilars allow the wider application of biological treatment. The objectives of this phase I clinical trial were to compare the pharmacokinetics, immunogenicity, and safety profiles of the biosimilar adalimumab-WIBP and the reference product Humira and to assess the precision of the bioequivalence evaluation.
Methods: In this randomized, double-blind, parallel-group bioequivalence study, 164 healthy male Chinese participants were selected and randomly divided into two groups on a 1:1 ratio.
Objective: Hec1 is a component of the Ndc80 kinetochore complex and is frequently upregulated in various cancers. However, the clinical significance of Hec1 in cervical cancer remains largely unknown. This study aimed to investigate the expression patterns of Hec1 in cervical cancer and its relationship with the clinicopathological characteristics of patients diagnosed with the disease.
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- - The study aimed to evaluate serum Numb as a potential early biomarker for predicting pre-eclampsia during the first trimester of pregnancy, enabling timely intervention.
- - A total of 1,024 women were observed from early pregnancy, and results showed significantly higher serum Numb levels in those who developed pre-eclampsia, with an odds ratio of 3.27 indicating increased risk.
- - Serum Numb demonstrated strong predictive capabilities, achieving an AUC value of 0.86, indicating that it could effectively help identify women at risk for pre-eclampsia early on in their pregnancy.
Impact of corticosteroids on initiation and half-year durability of humoral response in COVID-19 survivors.
Chin Med J Pulm Crit Care Med
March 2024
Background: The impact of corticosteroids on humoral responses in coronavirus disease 2019 (COVID-19) survivors during the acute phase and subsequent 6-month period remains unknown. This study aimed to determine how the use of corticosteroids influences the initiation and duration of humoral responses in COVID-19 survivors 6 months after infection onset.
Methods: We used kinetic antibody data from the lopinavir-ritonavir trial conducted at Jin Yin-Tan Hospital in January 2020, which involved adults hospitalized with severe COVID-19 (LOTUS, ChiCTR2000029308).
Article Synopsis
- This study investigates the role of ATG7, a protein involved in autophagy, in women with and without polycystic ovary syndrome (PCOS).
- It found that women with PCOS had significantly lower serum ATG7 levels compared to healthy women, which indicates an increased risk of developing the condition.
- The research suggests that ATG7 could be a potential biomarker for diagnosing and managing PCOS, especially in combination with HOMA-IR measurements.
Sepsis-associated encephalopathy (SAE) is a collection of clinical syndromes resulting from sepsis and characterized by widespread brain dysfunction. The high prevalence of SAE has adverse outcomes on the clinical management and prognosis of sepsis patients. However, currently, there are no effective treatments to ameliorate SAE.
View Article and Find Full Text PDFBackground: Our previous studies have indicated that mRNA and protein levels of PPIH are significantly upregulated in Hepatocellular Carcinoma (LIHC) and could act as predictive biomarkers for patients with LIHC. Nonetheless, the expression and implications of PPIH in the etiology and progression of common solid tumors have yet to be explored, including its potential as a serum tumor marker.
Methods: We employed bioinformatics analyses, augmented with clinical sample evaluations, to investigate the mRNA and protein expression and gene regulation networks of PPIH in various solid tumors.
Various substances in the blood plasma serve as prognostic indicators of the progression of COVID-19. Consequently, multi-omics studies, such as proteomic and metabolomics, are ongoing to identify accurate biomarkers. Cytokines and chemokines, which are crucial components of immune and inflammatory responses, play pivotal roles in the transition from mild to severe illness.
View Article and Find Full Text PDFFGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection.
Signal Transduct Target Ther
April 2024
The angiotensin-converting enzyme 2 (ACE2) is a primary cell surface viral binding receptor for SARS-CoV-2, so finding new regulatory molecules to modulate ACE2 expression levels is a promising strategy against COVID-19. In the current study, we utilized islet organoids derived from human embryonic stem cells (hESCs), animal models and COVID-19 patients to discover that fibroblast growth factor 7 (FGF7) enhances ACE2 expression within the islets, facilitating SARS-CoV-2 infection and resulting in impaired insulin secretion. Using hESC-derived islet organoids, we demonstrated that FGF7 interacts with FGF receptor 2 (FGFR2) and FGFR1 to upregulate ACE2 expression predominantly in β cells.
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- * A study investigated 1-year immune responses in COVID-19 survivors, comparing those who received corticosteroids during hospitalization to those who did not, focusing on neutralizing antibodies and T-cell responses.
- * Findings showed that corticosteroids did not significantly affect the levels of neutralizing antibodies or T-cell responses overall, but higher doses used for longer durations led to increased antibody titers and enhanced functionality of memory T-cells.
Article Synopsis
- Simnotrelvir, an oral protease inhibitor, showed promise in treating mild-to-moderate COVID-19 in a phase 2-3 clinical trial.
- In the study, patients received either simnotrelvir plus ritonavir or a placebo, with results indicating that those on the drug experienced faster resolution of symptoms compared to the placebo group.
- Although more adverse events were reported in the simnotrelvir group, most were mild to moderate, suggesting that the treatment is generally safe.
Article Synopsis
- Leritrelvir is a new drug designed to inhibit the SARS-CoV-2 main protease and has shown similar antiviral effects against various COVID-19 variants compared to nirmatrelvir.
- A phase 3 clinical trial evaluated the effectiveness and safety of leritrelvir monotherapy in adults with mild-to-moderate COVID-19, utilizing a randomized, double-blind, placebo-controlled design across 29 sites in China.
- Results indicated that patients receiving leritrelvir experienced significantly faster clinical recovery compared to those on placebo, highlighting its potential as an effective treatment option for early COVID-19 cases.
Article Synopsis
- The study explores the effectiveness and safety of VV116, an oral antiviral drug, in treating mild-to-moderate COVID-19 caused by SARS-CoV-2, particularly against the Omicron variant.
- Conducted as a phase 3 double-blind trial in China, 1369 adult participants were randomly assigned to receive either VV116 or a placebo over a 5-day period, ensuring that certain risk factors and vaccination statuses were considered.
- Preliminary results indicate that VV116 may be an effective treatment option, as analyzed through improvements in clinical symptom resolution time compared to the placebo group.
Background: There is a paucity of data on the natural trajectory of outcomes in survivors of COVID-19 beyond 2 years after symptom onset, and no evidence exists on the effect of re-infection in people with long COVID symptoms. We aimed to investigate the 3-year health outcomes of COVID-19 survivors and the effect of omicron re-infection.
Methods: In this single-centre, longitudinal cohort study, we recruited participants with confirmed COVID-19 who were discharged from the Jin Yin-tan hospital in Wuhan, China, between Jan 7 and May 29, 2020.
Article Synopsis
- The study explored the use of F61 nasal spray, a broad-spectrum neutralizing antibody, as an alternative method to manage the Omicron COVID-19 variants in China amid a shift from a strict zero-COVID strategy from late 2022 to early 2023.
- In a trial with 2,008 participants, those using F61 showed lower rates of SARS-CoV-2 infections in the multiple-dose group compared to the placebo, demonstrating significant efficacy.
- Real-world application of F61 among over 60,000 volunteers indicated over 90% efficacy against Omicron variants, highlighting its potential as a safe and effective prophylactic treatment against COVID-19.
Purpose: Preeclampsia affects between 2 to 8% of pregnancies worldwide and is associated with significant adverse outcomes for both mothers and their offspring. The present study aims to investigate whether there is a correlation between early age at menarche and an increased risk of developing preeclampsia and experiencing adverse neonatal outcomes.
Methods: The study involved a review of medical records of 4227 pregnant women who gave birth at The First Affiliated Hospital of Chengdu Medical College between January 2017 and December 2022.
Background: The long-term health consequences of COVID-19 remain largely unclear. The aim of this study was to describe the long-term health consequences of patients with COVID-19 who have been discharged from hospital and investigate the associated risk factors, in particular disease severity.
Methods: We did an ambidirectional cohort study of patients with confirmed COVID-19 who had been discharged from Jin Yin-tan Hospital (Wuhan, China) between Jan 7 and May 29, 2020.
Introduction: Acute respiratory distress syndrome and acute lung injury (ARDS/ALI) still lack a recognized diagnostic test and pharmacologic treatments that target the underlying pathology.
Methods: To explore the sensitive non-invasive biomarkers associated with pathological changes in the lung of direct ARDS/ALI, we performed an integrative proteomic analysis of lung and blood samples from lipopolysaccharide (LPS)-induced ARDS mice and COVID-19-related ARDS patients. The common differentially expressed proteins (DEPs) were identified based on combined proteomic analysis of serum and lung samples in direct ARDS mice model.