Development and Validation of a Biparametric MRI Deep Learning Radiomics Model with Clinical Characteristics for Predicting Perineural Invasion in Patients with Prostate Cancer.

Rationale And Objectives: Perineural invasion (PNI) is an important prognostic biomarker for prostate cancer (PCa). This study aimed to develop and validate a predictive model integrating biparametric MRI-based deep learning radiomics and clinical characteristics for the non-invasive prediction of PNI in patients with PCa.

Materials And Methods: In this prospective study, 557 PCa patients who underwent preoperative MRI and radical prostatectomy were recruited and randomly divided into the training and the validation cohorts at a ratio of 7:3.

Native T mapping for non-invasive quantitative evaluation of renal function and renal fibrosis in patients with chronic kidney disease.

Background: To investigate the role of native T mapping in the non-invasive quantitative assessment of renal function and renal fibrosis (RF) in chronic kidney disease (CKD) patients.

Methods: A prospective analysis of 71 consecutive patients [no RF (0%): 9 cases; mild RF (<25%): 36 cases; moderate RF (25-50%): 17 cases; severe RF (>50%): 9 cases] who were clinically diagnosed with CKD that was pathologically confirmed and who underwent magnetic resonance imaging (MRI) examination between October 2021 and September 2022 was performed. T-C (mean cortical T value), T-M (mean medullary T value), ΔT (mean corticomedullary difference) and T% (mean corticomedullary ratio) values were compared.

A nomogram based on LI-RADS features, clinical indicators and quantitative contrast-enhanced MRI parameters for predicting glypican-3 expression in hepatocellular carcinoma.

Purpose: Noninvasively assessing the tumor biology and microenvironment before treatment is greatly important, and glypican-3 (GPC-3) is a new-generation immunotherapy target for hepatocellular carcinoma (HCC). This study investigated the application value of a nomogram based on LI-RADS features, quantitative contrast-enhanced MRI parameters and clinical indicators in the noninvasive preoperative prediction of GPC-3 expression in HCC.

Methods And Materials: We retrospectively reviewed 127 patients with pathologically confirmed solitary HCC who underwent Gd-EOB-DTPA MRI examinations and related laboratory tests.

Calcium phosphate-based nanomedicine mediated CRISPR/Cas9 delivery for prostate cancer therapy.

Erythropoietin producing hepatocyte receptor A2 () is widely presented in the tumor cells, closely related to tumor cell migration, not cell apoptosis and proliferation. Based on its high expression in castration-resistant prostate cancer (CRPC), we herein develop a CRISPR-Cas9-based genome-editing nanomedicine to target erythropoietin producing hepatocyte receptor A2 for the treatment of castration-resistant prostate cancer. To this end, TAT was designed to stabilize the distribution of calcium, and then bound to ribonucleoprotein (RNP) to form nanoparticles RNP@CaP-TAT.

The Role of PSA Density among PI-RADS v2.1 Categories to Avoid an Unnecessary Transition Zone Biopsy in Patients with PSA 4-20 ng/mL.

Objective: To evaluate the role of prostate-specific antigen density (PSAD) in different Prostate Imaging Reporting and Data System version 2.1 (PI-RADS v2.1) categories to avoid an unnecessary biopsy in transition zone (TZ) patients with PSA ranging from 4 to 20 ng/mL.

Diagnostic Accuracy and Interobserver Agreement of PI-RADS Version 2 and Version 2.1 for the Detection of Transition Zone Prostate Cancers.

PI-RADS version 2.1 (v2.1) introduced a number of key changes to the assessment of transition zone (TZ) lesions.

Biparametric prostate MRI and clinical indicators predict clinically significant prostate cancer in men with "gray zone" PSA levels.

Purpose: To predict clinically significant prostate cancer (cs-PCa) by combining the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) score based on biparametric magnetic resonance imaging (bp-MRI) and clinical indicators in men with prostate-specific antigen (PSA) levels in the gray zone of 4-10 ng/mL.

Method: We retrospectively analyzed 364 patients with elevated PSA levels in the gray zone who had pathologically confirmed disease and had undergone MRI examinations from January 2015 to October 2019; a training group (n = 255) and validation group (n = 109) were randomly established. Multivariate logistic regression analysis of the training group was performed to identify the independent predictors for cs-PCa, thereby establishing a predictive model that was evaluated in the training and validation groups by analyzing the receiver operating characteristic (ROC) curve.

Lexical tone and word recognition in noise of Mandarin-speaking children who use cochlear implants and hearing aids in opposite ears.

The benefits of bimodal hearing (cochlear implant and hearing aid in opposite ears) in children are well documented in English-speaking populations (Ching et al., 2000; Holt et al., 2005) but not much evidence has been reported from populations using tonal languages.

Auditory pre-attentive processing of Chinese tones.

Background: Chinese tones are considered important in Chinese discrimination. However, the relevant reports on auditory central mechanisms concerning Chinese tones are limited. In this study, mismatch negativity (MMN), one of the event related potentials (ERP), was used to investigate pre-attentive processing of Chinese tones, and the differences between the function of oddball MMN and that of control MMN are discussed.

[Establishment and rudimentary application of the method of recording auditory brainstem responses electrically stimulated via round-window niche in cochlear implants].

Objective: To establish the method of recording auditory brainstem responses electrically stimulated via round-window niche in cochlear implants.

Methods: Self-made platinum iridium alloy as a spherical electrode stimulation electrode, modified cochlear implants connected to in vitro speech processor as a electro-stimulator and evoke potential instrument for Bio-logic Navigator Pro, 17 cochlear implant patients with various ages and of different causes, including auditory neuropathy (2 cases), ossified cochlea (1 case), inner ear malformation (5 cases), leukodystrophy (1 case), unknown and reason (8 cases) were investigated during cochlear implant surgery. Before cochlear implantation, stimulation electrode was placed in the round-window niche while charge balanced biphasic constant current was used as electrical stimulation via round window niche, and then electrically evoked auditory brainstem response was recorded.

[Local response caused by implant after cochlear implantation].

Objective: To approach the incidence rate, symptoms, etiologies, correlating reasons, consequences and treatments of local responses caused by implant after cochlear implantation and to provide reference for the future works.

Methods: From 1995 to 2007 there were 997 cases adopted cochlear implantation in Peding Union Medical College Hospital. Ten cases experienced local responses were analyzed retrospectively.

Speech recognition and temporal amplitude modulation processing by Mandarin-speaking cochlear implant users.

Objectives: Fundamental frequency (F0) information is important to Chinese tone and speech recognition. Cochlear implant (CI) speech processors typically provide limited F0 information via temporal envelopes delivered to stimulating electrodes. Previous studies have shown that English-speaking CI users' speech performance is correlated with amplitude modulation detection thresholds (AMDTs).

[Screening of SLC26A4 (PDS) gene mutation in cochlear implant recipients with inner ear malformation].

Objective: To determine the prevalence of SLC26A4 (PDS) gene mutations in cochlear implant recipients with inner ear malformation, and the correlation between SLC26A4 (PDS) gene mutation and inner ear malformation and intra-operative testing of the electrically evoked auditory nerve compound action potentials (ECAP).

Methods: Peripheral blood samples were collected from 48 cochlear implant recipients with temporal bone malformation and 50 healthy controls. Genomic DNA was extracted from the blood; PCR and direct sequencing were used to detect the mutations of SLC26A4 (PDS) gene.

[Cochlear implantation in patients with otitis media-related diseases].

Objective: To evaluate the indications, surgical techniques and complications of cochlear implantation in patients with otitis media-related diseases.

Methods: Retrospective study of the data collected from patients receiving cochlear implantation. Totally 866 cases of cochlear implantation were performed in Peking Union Medical College Hospital from May 1995 to February 2006.

[High prevalence of connexin-26 (GJB2) mutation in cochlear implant recipients].

Objective: To determine the prevalence of GJB2 gene mutations in patients undergoing cochlear implantation.

Methods: We enrolled 115 cochlear implant recipients for mutation screening. Genomic DNA was extracted from the blood of all patients, amplified in PCR and analyzed for single strand conformation polymorphism (SSCP) or direct sequencing to detect mutations of GJB2 gene.

[Voice analysis in pre-lingual cochlear implant adults].

Objective: To observe voice characteristic of pre-lingual cochlear implant adults for cochlear implantation and phoniatrics.

Methods: 3s-sustained voice of vowel [ a: ] of 28 pre-lingual cochlear implant adults, 18 pre-lingual deafness adults and 10 adults with normal hearing were analyzed. Specifically, the Voice analyses include fundamental frequency, first formant, second formant, frequency perturbation quotient (FPQ), amplitude perturbation quotient (APQ) and harmonic noise ratio (HNR).

[Clinical review of cochlear implant in 533 cases].

Objective: To summarize and analyze the etiology, surgical indications, operation methods and outcomes of cochlear implantation.

Methods: 533 cases (534 ears) with severe and profound hearing loss received cochlear implant, 489 were pre-lingual deafness and 38 cases were post-lingual deafness. Their ages at implant, 1 to approximately 3 were 167, approximately 5 were 77, approximately 7 were 73, approximately 14 were 136, approximately 17 were 28, >17 were 52.

Mandarin tone recognition in cochlear-implant subjects.

This study examined tone recognition in five cochlear-implant subjects who were native speakers of Mandarin and used a Nucleus-22 device. Psychophysical experiments were conduced to measure rate discrimination in individual electrodes from the most apical to the most basal electrodes. The rate range was from 100 to 200 Hz, which corresponded to the range of variation in fundamental frequency for the tonal tokens used in this study.

[Tone recognition and electrode discrimination in prelingually deafened cochlear-implant listeners].

Objective: To investigate tone recognition and electrode discrimination in prelingually deafened children with the Nucleus device, and to develop guidelines for customized mapping in the implant users.

Methods: Fourteen prelingually deafened children with cochlear implants participated in this study. Tone recognition was measured with a four-alternative, forced choice procedure from 25 consonant-vowel syllables, each of which had four tonal variations.

[The transduction of neurotrophin-3/GDNF attenuates the SGNC damage in deaf mice].

Objective: To investigate the attenuation of cisplatin-induced toxicity in the spiral ganglion neuron (SGNC) by the localized expression of the neurotrophin-3 (NT-3) and glial cell line-derived nerutrophic factor (GDNF) via HSV-Amplicon.

Methods: We constructed the HSV-Amplicon vectors, which could express the NT-3 and GDNF under separate transcriptional control. Helper virus-free amplicon stocks were assessed in vitro for their capacity in the cultured inner ear cells.

[Implication of cochlear implantation in patients with enlarged vestibular aqueduct syndrome].

Objective: To evaluate the intraoperative obstacles and post-operative outcomes of cochlear implantation in children with enlarged vestibular aqueduct syndrome.

Methods: Between May 1995 and June 2002, 10 patients with enlarged vestibular aqueduct syndrome received cochlear implantation in Pekin Union Medical College Hospital. The clinical records of 10 cases of enlarged vestibular aqueduct syndrome were analyzed retrospectively.