[Design, synthesis and insulin-sensitizing activity of some peroxisome proliferator-activated gamma agonists].

Aim: To find new peroxisome proliferator-activated y agonists with high activity and low toxicity.

Methods: Based on JTT-501 and JTT-20993, new isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds were designed and synthesized. Their insulin-sensitizing activities were evaluated.