Publications by authors named "Chao-Zheng Zhou"
Article Synopsis
- This study explores how certain genomic alterations in breast cancer might be connected, influencing both the biological characteristics of the cancer and the effectiveness of treatments.
- Researchers analyzed data from large cohorts (873 and 4,405 patients) and tested ideas using patient-derived models.
- Key findings link specific genetic alterations to treatment responses, suggesting that understanding these interactions could lead to better, personalized treatment strategies for patients.
Triple-negative breast cancer (TNBC) is an aggressive disease characterized by remarkable intratumor heterogeneity (ITH), which poses therapeutic challenges. However, the clinical relevance and key determinant of ITH in TNBC are poorly understood. Here, we comprehensively characterized ITH levels using multi-omics data across our center's cohort (n = 260), The Cancer Genome Atlas cohort (n = 134), and four immunotherapy-treated cohorts (n = 109).
View Article and Find Full Text PDFHerein, the first acceptorless dehydrogenation of tetrahydroquinolines (THQs), indolines, and other related N-heterocycles, by merging visible-light photoredox catalysis and cobalt catalysis at ambient temperature, is described. The potential applications to organic transformations and hydrogen-storage materials are demonstrated. Primary mechanistic investigations indicate that the catalytic cycle occurs predominantly by an oxidative quenching pathway.
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