Publications by authors named "Chao-Yang Zeng"
Pancreatic cancer ranks fourth among cancer-related deaths with a low 5-year overall survival rate of less than 13%. At present, treatment of pancreatic cancer is still based on chemotherapy, but the efficacy is limited. Thus, a novel therapeutic agent for pancreatic cancer therapy is urgently needed.
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- Three chromomycin derivatives were identified from soil bacteria, specifically chromomycins A and monodeacetylchromomycin A, with their structures and absolute configurations analyzed using advanced techniques like NMR.
- These compounds demonstrated strong cytotoxic effects against various non-small-cell lung cancer (NSCLC) cells and were found to lower the protein levels of c-FLIP in one of the cancer cell lines.
- In animal studies, the chromomycins were more effective at inhibiting tumor growth in specific conditions, indicating that c-FLIP plays a significant role in the anticancer activity of these compounds.
Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis of breast cancer. Thiostrepton exerts anti-tumor activities against several cancers including TNBC. Herein we discussed the new molecular mechanisms of thiostrepton in TNBC.
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