Publications by authors named "Chao-Xin Li"
Angelicae Sinensis Radix excels in activating blood, but the scientific mechanism has not been systematically analyzed, thus limiting the development of the medicinal. This study employed the computer-aided drug design methods, such as structural similarity-based target reverse prediction, complex network analysis, molecular docking, binding free energy calculation, cluster analysis, and ADMET(absorption, distribution, metabolism, excretion, toxicity) calculation, and enzyme activity assay in vitro, to explore the components and mechanism of Angelicae Sinensis Radix in activating blood. Target reverse prediction and complex network analysis yielded 40 potential anticoagulant targets of the medicinal.
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- - The study explores how bone's layered structure affects its mechanical properties and the movement of fluids, which are crucial for processes like bone adaptation and remodeling.
- - Using a multiscale modeling approach and COMSOL Multiphysics, researchers created detailed bone models to analyze stress, strain, and fluid dynamics at different scales, validating the accuracy of their models.
- - Results indicate significant variations in fluid pressure, velocity, and stresses throughout different regions of the bone, highlighting the impact of bone structure on these factors and emphasizing the important roles of endosteum and periosteum in fluid flow.