Publications by authors named "Chao-Qun Luo"
Objective: The utility of metagenomic next-generation sequencing (mNGS) in the diagnosis of tuberculous meningitis (TBM) remains uncertain. We performed a meta-analysis to comprehensively evaluate its diagnostic accuracy for the early diagnosis of TBM.
Methods: English (PubMed, Medline, Web of Science, Cochrane Library, and Embase) and Chinese (CNKI, Wanfang, and CBM) databases were searched for relevant studies assessing the diagnostic accuracy of mNGS for TBM.
Article Synopsis
- Tuberculous meningitis (TBM) is the leading form of central nervous system tuberculosis, associated with high rates of mortality and disability, making early diagnosis crucial for improving patient outcomes.
- The traditional diagnostic methods for TBM, which include microscopy, culture, and PCR, are often ineffective due to the low bacterial load in the cerebrospinal fluid (CSF) and the limitations of conventional techniques.
- This review highlights the current landscape of TBM diagnostics, emphasizing ongoing research, the pros and cons of available methods, and the challenges clinicians face in ensuring accurate and efficient diagnosis.
Background: Tuberculous meningitis (TBM) is the most serious form of extrapulmonary tuberculosis caused by , and is characterized by high morbidity and mortality. Unfortunately, it is difficult to distinguish TBM from bacterial meningitis (BM) based on clinical features alone. The latest diagnostic tests and neuroimaging methods are still not available in many developing countries.
View Article and Find Full Text PDF