Publications by authors named "Chao-Qun Lian"
Article Synopsis
- The study investigates how bone morphogenetic protein 4 (BMP4) affects the cell cycle and apoptosis (cell death) of hematopoietic stem and progenitor cells (HSPC) during bone marrow suppression induced by 5-fluorouracil (5-FU).
- Researchers created C57BL transgenic mice overexpressing BMP4 and compared them to wild-type (WT) mice under similar conditions to assess changes in HSPC.
- Results showed that BMP4 overexpression led to reduced HSPC in a resting phase (G0) and increased apoptosis during bone marrow suppression, suggesting BMP4 might influence HSPC cell cycles by lowering levels of certain regulatory factors like Hif-1