Identify origin of replication in Saccharomyces cerevisiae using two-step feature selection technique.

Motivation: DNA replication is a key step to maintain the continuity of genetic information between parental generation and offspring. The initiation site of DNA replication, also called origin of replication (ORI), plays an extremely important role in the basic biochemical process. Thus, rapidly and effectively identifying the location of ORI in genome will provide key clues for genome analysis.

iTerm-PseKNC: a sequence-based tool for predicting bacterial transcriptional terminators.

Motivation: Transcription termination is an important regulatory step of gene expression. If there is no terminator in gene, transcription could not stop, which will result in abnormal gene expression. Detecting such terminators can determine the operon structure in bacterial organisms and improve genome annotation.

A Brief Survey of Machine Learning Application in Cancerlectin Identification.

Proteins with at least one carbohydrate recognition domain are lectins that can identify and reversibly interact with glycan moiety of glycoconjugates or a soluble carbohydrate. It has been proved that lectins can play various vital roles in mediating signal transduction, cell-cell recognition and interaction, immune defense, and so on. Most organisms can synthesize and secret lectins.