Relationship between survivin expression and recurrence, and prognosis in hepatocellular carcinoma.

Aim: To study the expression of the inhibitor of apoptosis protein survivin in hepatocellular carcinoma (HCC), and its correlation with clinicopathological factors, cell proliferation, recurrence and prognosis after hepatectomy.

Methods: Immunohistochemical staining of survivin and Ki-67 was performed by the standard streptavidin-peroxidase technique on paraffin sections of 55 cases of HCC.

Results: The positive rate of survivin in HCC was 52.