Publications by authors named "Chao-Peng Xiong"
Circulating levels of free fatty acids (FFAs) are often found to be increased in patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS). High plasma FFA levels may give rise to maladaptive macrophage activation and promote inflammatory responses, which has been proposed as a potential mechanism for the development of DM and MS. P2X4 receptor (P2X4R), a ligand-gated cation channel activated by extracellular adenosine triphosphate (ATP), plays a primary role in the regulation of inflammatory responses.
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- - The study investigates how genetic variations in the oestrogen receptor α (ER-α) and osteocalcin (BGP) affect fasting plasma glucose (FPG) levels, which are important for metabolic health and show significant heritability.
- - Researchers analyzed 328 pre-menopausal Chinese women and found a notable link between ER-α PvuII genotypes and FPG levels, along with a significant interaction between this polymorphism and BGP HindIII, although BGP HindIII alone did not show a direct connection to FPG.
- - The findings suggest that specific genetic variants in the ER-α gene and their interaction with BGP may play a role in regulating fasting plasma glucose in this population group, highlighting