Longevity, tumor, and physical vitality in rats consuming ginsenoside Rg1.

Background: Effects of the major ginsenoside Rg1 on mammalian longevity and physical vitality are rarely reported.

Purpose: To examine longevity, tumor, and spontaneous locomotor activity in rats consuming Rg1.

Methods: A total of 138 Wistar rats were randomized into 2 groups: control (N = 69) and Rg1 (N = 69).

Reduced stem cell aging in exercised human skeletal muscle is enhanced by ginsenoside Rg1.

Background: Stem cell aging, characterized by elevated p16 expression, decreases cell repopulating and self-renewal abilities, which results in elevated inflammation and slow recovery against stress.

Methods: Biopsied muscles were analyzed at baseline and 24 h after squat exercise in 12 trained men (22 ± 2 y). Placebo (PLA) and immunostimulant Rg1 (5 mg) were supplemented 1 h before a squat exercise, using a double-blind counterbalanced crossover design.

Whole-life body composition trajectory and longevity: role of insulin.

The present study assessed the body composition trajectory of rats (N = 96) placed into 5 groups according to lifespan, using dual-energy x-ray absorptiometry every 6 months until end-of-life. A striking linearity between lifespan and bone mass percentage (not absolute bone mass) was observed. Long-lived rats show a higher bone mass percentage with a delayed insulin rise to a similar peak level as short-lived counterparts, followed by insulin declines and bone mass loss.