Decreased expression of endometrial vessel AQP1 and endometrial epithelium AQP2 related to anovulatory uterine bleeding in premenopausal women.

Objective: Aquaporins (AQPs) may be involved in the occurrence of abnormal uterine bleeding as the mediators between ovarian steroids and cyclic endometrial changes. The aim of the present study was to investigate the characteristics of endometrial AQPs in women with anovulatory uterine bleeding and explore the relationship between endometrial AQPs and ovarian steroids.

Design: Sixty-one women with premenopausal anovulatory uterine bleeding and 108 women with normal cycles were involved in this study.

Expression of aquaporin-1 in normal, hyperplasic, and carcinomatous endometria.

Objective: To explore the relationship between aquaporin-1 (AQP1) and endometrial adenocarcinoma.

Method: Intratumoral microvessel density (IMD) was assessed as well as AQP1 and vascular endothelial growth factor expression in samples from 117 women, 75 with endometrioid adenocarcinoma, 17 with endometrial hyperplasia, and 25 with normal proliferative endometria.

Results: AQP1 was located in the epithelial cells of microvessels and small vessels in all samples.

[Expression profile of aquaporin 1 in patients with menorrhagia].

Objective: To investigate the expression of aquaporin 1 (AQP1) in endometrium of patients with menorrhagia.

Methods: RT-PCR and immunohistochemistry were carried out in twenty women with normal menstrual cycle to confirm the expression of AQP1 in endometrium and locate it. Then 51 women with menorrhagia and 40 women with normal menstrual cycle were included in the study.

Function of aquaporins in female and male reproductive systems.

The flow of water and some other small molecules across cell membranes is important in many of the processes underlying reproduction. The fluid movement is strongly associated with the presence of aquaporins (AQPs) in the female and male reproductive systems. It has been suggested that AQPs mediate water movement into the antral follicle and play important roles in follicle development.