ln RNA LINC01234 promotes triple-negative breast cancer progression through regulating the miR-429/SYNJ1 axis.

Emerging evidence has illustrated that long noncoding RNA 01234 (LINC01234) has played a pivotal role in the development and progression of human cancer. The regulatory role and underlying mechanisms of LINC01234 in triple-negative breast cancer (TNBC) remains unknown. In this study, we analyzed the expression level of LINC01234 in several breast cancer cell lines.

[CT value of vertebral body predicting Cage subsidence after stand-alone oblique lumbar interbody fusion].

Objective: To investigate the correlation between CT value and Cage subsidence in patients with lumbar degenerative disease treated with stand-alone oblique lumbar interbody fusion (OLIF).

Methods: The clinical data of 35 patients with lumbar degenerative diseases treated with stand-alone OLIF between February 2016 and October 2018 were retrospectively analyzed. There were 15 males and 20 females; the age ranged from 29 to 81 years, with an average of 58.

Analysis of salivary proteomic biomarkers for the surveillance of changes in high-risk status of early childhood caries.

Background: Early childhood caries is an urgent public health concern. The aim of this study was to investigate salivary proteomic biomarkers for the surveillance of changes in the high-risk status of early childhood caries. The process involves the screening of specific salivary peptides that were differentially expressed only under dynamic changes in individual caries status.

Does Chronic Kidney Disease Affect the Surgical Outcome and Prognosis of Patients with Gastric Cancer? A Meta-Analysis.

The purpose of this meta-analysis was to evaluate the impact of chronic kidney disease on short-term complications and long-term survival in patients with gastric cancer. The PubMed, Embase, and Cochrane Library databases were searched from inception to May 18, 2021. The search strategy focused on two keywords: chronic kidney disease and gastric cancer.

The Role of MicroRNAs in Therapeutic Resistance of Malignant Primary Brain Tumors.

Brain tumors in children and adults are challenging tumors to treat. Malignant primary brain tumors (MPBTs) such as glioblastoma have very poor outcomes, emphasizing the need to better understand their pathogenesis. Developing novel strategies to slow down or even stop the growth of brain tumors remains one of the major clinical challenges.

Potential Roles of the Free Salivary Microbiome Dysbiosis in Periodontal Diseases.

Saliva is a vital mediator in the oral cavity. The dysbiosis of free bacteria in saliva might be related to the onset, development, prognosis, and recurrence of periodontal diseases, but this potential relationship is still unclear. The objective of this study was to investigate the potential roles of the free salivary microbiome in different periodontal statuses, their reaction to nonsurgical periodontal therapy, and differences between diseased individuals after treatment and healthy persons.

The protective mechanism of a debranched corn starch/konjac glucomannan composite against dyslipidemia and gut microbiota in high-fat-diet induced type 2 diabetes.

This study aimed to explore the protection mechanism of a debranched corn starch/konjac glucomannan (DCSK) composite against type 2 diabetes (T2D) related to dyslipidemia and gut microbiota in mice fed on a high-fat diet (HFD). The results showed that the consumption of DCSK led to a significant improvement in the biochemical parameters and physiological indices associated with T2D in the HFD group, including the decrease in blood glucose, triglyceride, total cholesterol, and high-density lipoprotein cholesterol levels, as well as the suppression of the oxidative stress of the liver and kidneys. Furthermore, the health of the intestinal microbiota in the HFD-fed mice was altered dramatically after DCSK consumption.

The effects of removing dead bacteria by propidium monoazide on the profile of salivary microbiome.

Background: Oral microbiome played an important role in maintaining healthy state and might exhibit certain changes under circumstances of diseases. However, current microbiological research using sequencing techniques did not regard dead bacteria as a separate part, causing findings based on subsequent analyses on dynamic equilibrium and functional pathways of microbes somewhat questionable. Since treatment by propidium monoazide (PMA) was able to remove dead bacteria effectively, it would be worth studying how the sequencing results after PMA treatment differed from those focusing on the whole microbiota.

Impact of the COVID-19 pandemic: Insights from vacation rentals in twelve mega cities.

Coronavirus disease 2019 (COVID-19) is a challenging global problem. COVID-19 has caused shocks to various urban systems, and the tourism industry is no exception. We analyzed the impact on vacation rentals by conducting diachronic data mining on nearly 10 GB of rental data (calendar, listings, and reviews) in twelve highly internationalized megacities distributed across Asia, Europe, America, and Oceania based on the data set from the Inside Airbnb website.

Smoothened is a therapeutic target for reducing glutamate toxicity in ischemic stroke.

Extracellular glutamate contributes to brain damage in ischemia. Under physiological conditions, glutamate transporters are responsible for regulating its intracellular/extracellular concentrations in the brain. However, how the extracellular glutamate is regulated in ischemia remains unclear.

Does Extended Intraoperative Peritoneal Lavage Really Bring Benefit on Patients With Gastric Cancer? A Meta-Analysis of Published Clinical Trials.

Purpose: The purpose of the current meta-analysis is to analyze whether extended intraoperative peritoneal lavage (EIPL) can bring benefit on short-term outcomes or survival for patients undergoing curative gastrectomy for gastric cancer.

Methods: The PubMed, Embase, and Cochrane Library databases were searched from inception to May 3, 2021, to find eligible studies. Postoperative complications, overall survival (OS), disease-free survival (DFS), and peritoneal recurrence-free survival (PRFS) were compared between EIPL group and No EIPL group.

The economic benefits of increased sugar-free chewing gum in China: a budget impact analysis.

Background: To analyze the potential cost savings in dental care associated with increased sugar-free gum (SFG) use among Chinese teenagers and adults.

Methods: The amount of SFG chewed per year and decayed, missing and filled teeth (DMFT) was collected from a cross-sectional survey to create a dose-response curve assumption. A cost analysis of dental restoration costs was carried out.

A Novel Azaphilone Muyophilone A From the Endophytic Fungus 0307-2.

Two known azaphilone derivatives, 4,6-dimethylcurvulinic acid () and austdiol (), and their novel heterotrimer, muyophilone A (), were isolated and identified from an endophytic fungus, 0307-2. Their structures and stereochemistry were established by extensive spectroscopic analyses including HRMS, NMR spectroscopy, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectroscopic methods, as well as single crystal X-ray diffraction. In the structure of , two compound -derived azaphilone units were connected through an unprecedented five-membered carbon bridge which was proposed to be originated from compound .

Harmful macroalgal blooms (HMBs) in China's coastal water: Green and golden tides.

Harmful macroalgal blooms (HMBs) have been increasing along China's coasts, causing significant social impacts and economic losses. Besides extensive eutrophication sustaining coastal seaweed tides, the stimuli and dynamics of macroalgal blooms in China are quite complex and require comprehensive studies. This review summarizes the distinct genesis, development and drifting patterns of three HMBs that have persistently occurred in China's coastal waters during recent years: transregional green tides of drifting Ulva prolifera in the Yellow Sea (YS), local green tides of multiple suspended seaweeds in the Bohai Sea and large-scale golden tides of pelagic Sargassum horneri in the YS and East China Sea.

Conductive single-wall carbon nanotubes/extracellular matrix hybrid hydrogels promote the lineage-specific development of seeding cells for tissue repair through reconstructing an integrin-dependent niche.

Background: The niche of tissue development in vivo involves the growth matrix, biophysical cues and cell-cell interactions. Although natural extracellular matrixes may provide good supporting for seeding cells in vitro, it is evitable to destroy biophysical cues during decellularization. Reconstructing the bioactivities of extracellular matrix-based scaffolds is essential for their usage in tissue repair.

Effects of tree plantings and aspect ratios on pedestrian visual and thermal comfort using scaled outdoor experiments.

Urban trees ameliorate heat stress for urban dwellers. However, it is difficult to quantitatively assess the integrated impacts of tree planting and street layouts on visual and thermal comfort in simulations and urban field experiments. We conducted scaled outdoor experiments in Guangzhou to investigate the influence of tree plantings on pedestrian visual and thermal comfort in street canyons with various aspect ratios (H/W = 1, 2, 3; H = 1.

Screening and Interaction Analysis Identify Genes Related to Anther Dehiscence in L.

Anther indehiscence is an important form of functional male sterility that can facilitate the production of hybrid seeds. However, the molecular mechanisms of anther indehiscence-based male sterility in eggplant ( L.) have not been thoroughly explored.

PIWI‑interacting RNA in cancer: Molecular mechanisms and possible clinical implications (Review).

PIWI‑interacting RNA is a class of non‑coding small RNA that is ~30 nt long and is primarily found in mammalian germ cells from mice and humans. In cooperation with the members of PIWI protein family, this macromolecule participates in germ cell development, inhibits DNA self‑-replication and maintains genomic stability. Increasing evidence has demonstrated that PIWI‑interacting RNA (piRNAs) are abnormally expressed in various human cancers, such as liver cancer, stomach cancer, colorectal cancer, osteosarcoma, breast cancer, lung cancer, prostate cancer, etc.

Fertilization time of slow-release fertilizer affects the physicochemical properties of starch from spring-sown waxy maize.

Background: Slow-release fertilizer is widely used in cereal crop production because it is ecofriendly and laborsaving. Effects of different application stages (zero-, three-, and six-leaf stages, denoted as SN0, SN3, and SN6, respectively) of slow-release (N/P O /K O = 225/75/75 kg ha ) fertilizer on physicochemical properties of starch from spring-sown waxy maize were investigated in 2018 and 2019. Application of traditional fertilizer (NCK, compound fertilizer; N/P O /K O = 75/75/75 kg ha ) at sowing time and urea (N = 150 kg ha ) at six-leaf stage was designated as the control.

Effect of chain length on the structure and physicochemical properties of active compound/linear dextrin composites.

Three linear dextrins (LDs) with different chain length were obtained through fractionating short-chain LD by gradient precipitation with 65%, 70% and 75% alcohol, signed as 65LD, 70LD, and 75LD, respectively. The LDs were employed to encapsulate arachidonic acid (ARA) and geranic acid (GA). Fourier infrared spectrometry, differential scanning calorimetry and thermogravimetric analysis confirmed the formation of ARA/LD and GA/LD composites.

A High-Throughput Nanofluidic Device for Exosome Nanoporation to Develop Cargo Delivery Vehicles.

Efficient loading of various exogenous cargos into exosomes while not affecting their integrity and functionalities remains a major challenge. Here, a nanofluidic device named "exosome nanoporator (ENP)" is presented for high-throughput loading of various cargos into exosomes. By transporting exosomes through nanochannels with height comparable to their dimension, exosome membranes are permeabilized by mechanical compression and fluid shear, allowing the influx of cargo molecules into the exosomes from the surrounding solution while maintaining exosome integrity.

miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5.

Background: miR-198 is involved in the formation, migration, invasion, and metastasis of various malignant cancers. However, the function and mechanism of action of miR-198 in the tumorigenesis of renal cell carcinoma (RCC) remain elusive. Here, we aimed to explore the role of miR198 in RCC.

Capped L-norm metric based robust least squares twin support vector machine for pattern classification.

Least squares twin support vector machine (LSTSVM) is an effective and efficient learning algorithm for pattern classification. However, the distance in LSTSVM is measured by squared L-norm metric that may magnify the influence of outliers. In this paper, a novel robust least squares twin support vector machine framework is proposed for binary classification, termed as CL-LSTSVM, which utilizes capped L-norm distance metric to reduce the influence of noise and outliers.