Preventive hyperbaric oxygen therapy improves acute graft-versus-host disease by activating the Nrf2/HO-1 pathway.

Background: Hyperbaric oxygen therapy (HBOT) has been confirmed as an effective and economical therapeutic modality for treating hemorrhagic cystitis (HC), whether induced by infection or acute graft-versus-host disease (aGVHD), in transplant recipients. However, its potential benefits in treating aGVHD remain largely unknown. This study explored the effects of HBOT on aGVHD and its underlying mechanisms.

Chromosome-level genome assembly of the short-faced mole (Scaptochirus moschatus).

The short-faced mole (Scaptochirus moschatus) belonging to the family Talpidae in the order Eulipotyphla is a good model for studying adaptive evolution of mammals because of its morphological and ecological characteristics. However, the lack of genome of short-faced mole has hindered previous studies. In this study, we assembled the genome of the short-faced mole based on Illumina, PacBio HiFi and Hi-C sequencing, and acquired the genome of the short-faced mole with the size of 2.

Mesenchymal stem cells alleviate idiopathic pneumonia syndrome by facilitating M2 polarization via CCL2/CCR2 axis and further inducing formation of regulatory CCR2 + CD4 + T cells.

Background: Our previous study revealed that mesenchymal stem cells (MSCs) can secrete large amounts of the chemokine CCL2 under inflammatory conditions and alleviate idiopathic pneumonia syndrome (IPS) by promoting regulatory CCR2 + CD4 + T-cell formation through the CCL2‒CCR2 axis. Given the abundance of macrophages in lung tissue, how these macrophages are regulated by MSC-based prophylaxis via IPS and their interactions with T cells in lung tissue during allo-HSCT are still not fully understood.

Methods: An IPS mouse model was established, and MSC-based prophylaxis was administered.

[Screening and Preliminary Validation of Multiple Myeloma Specific Proteins].

Objective: To screen novel diagnostic marker or therapeutic target for multiple myeloma (MM).

Methods: and were identified by bioinformatics method based on GEO database as high expression genes in MM. Their RNA and protein expression levels in bone marrow mononuclear cells from myeloma cell lines U266, NCI-H929, MM.

Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys.

Chronic kidney disease (CKD) is a progressive condition that can lead to chronic renal failure (CRF), affecting 8%-16% of adults globally and imposing a significant burden on healthcare systems. Renal fibrosis is a key pathological hallmark of CKD progression and is linked to poor prognosis. Multiple signaling pathways, including WNT/β-catenin.

Spatial heterogeneity of corneal biomechanical properties in myopia at nanoscale: A preliminary study.

Purpose: To investigate the spatial heterogeneity of the corneal biomechanical properties in individuals with non-high and high myopia.

Methods: Atomic force microscopy was used to quantify the region-dependent elastic modulus (E) of 34 corneal lenticules from keratorefractive lenticule extraction surgery. The local E values of the central region, as well as the superior, inferior, nasal, and temporal points at the pericentral region, were measured.

Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment.

Background: Cardiovascular diseases (CVDs) marked with cardiac morphological or hemodynamical abnormalities are associated with mild cognitive impairment (MCI). The links between cardiac structure and function and MCI are not well understood. We aimed to explore the association between echocardiographic parameters of cardiac structure and function and MCI in CVD patients.

Bioinspired Super-Robust Conductive Hydrogels for Machine Learning-Assisted Tactile Perception System.

Conductive hydrogels have attracted significant attention due to exceptional flexibility, electrochemical property, and biocompatibility. However, the low mechanical strength can compromise their stability under high stress, making the material susceptible to fracture in complex or harsh environments. Achieving a balance between conductivity and mechanical robustness remains a critical challenge.

STAT4 gene polymorphism may be associated with microscopic polyangiitis susceptibility in a Chinese Guangxi population: A case-control analysis based on propensity score matching.

Background: Microscopic polyangiitis (MPA) is a severe multisystem autoimmune disease featured by small-vessel vasculitis with few or no immune complex, also has a significant genetic predisposition. Growing evidence has confirmed that STAT4 gene is tightly associated with multiple autoimmune diseases, but its contribution to MPA onset is still elusive.

Objective: The aim was to investigated the association between STAT4 gene polymorphisms (rs7572482, rs7574865 and rs12991409) and MPA susceptibility in a Guangxi population of China.

High perioperative lactate levels as a potential predictor for severe acute kidney injury following aortic arch surgery.

Background: Acute type A aortic dissection (ATAAD) is a life-threatening condition that often requires total aortic arch replacement (TAR) combined with frozen elephant trunk (FET) implantation. Despite advancements in surgical techniques and preoperative management, postoperative acute kidney injury (AKI) remains a prevalent complication that significantly affects patient prognosis, particularly severe AKI. The aim of this study was to investigate the predictive value of perioperative lactate levels in severe postoperative AKI after TAR.

Compositional Differences of Various Sorption States of Cu and Cd on Goethite in the Presence of Oxyanions: A Quantitative Study.

The anionic species of antimony(V) and phosphate(V) are commonly found in the contaminated soil of mining areas, exerting a significant influence on the sorption of heavy metals and thus affecting their migration. This study quantitatively discussed the sorption mechanism of Sb and P in promoting the sorption of Cd or Cu on goethite through a series of extraction methods. In the single sorption system, the majority of Cu (87-98%) is adsorbed on goethite in the form of EDTA-extractable Cu (EF Cu, possibly inner-sphere complexes) under pH conditions of 3.

Association of tyrosine kinase 2 polymorphisms with susceptibility to microscopic polyangiitis in a Guangxi population.

Background: Heredity and epigenetics affect the pathogenesis of microscopic polyangiitis (MPA). Tyrosine kinase 2 (TYK2) polymorphisms (rs2304256C > A, rs280519A > G, and rs12720270G > A) may be potential protective factors against anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Current research suggests that TYK2 is associated with various autoimmune diseases; however, no study has examined the relationship between TYK2 polymorphisms and AAV.

Two detoxification enzyme genes, and , mediate the susceptibility to afidopyropen in .

Introduction: is an important economic pest affecting Caprifoliaceae and Apiaceae plants, and chemical control is still the main effective control method in the field. Afidopyropen is a new type of pyridine cyclopropyl insecticide, which can effectively control piercing-sucking mouthparts pests and is suitable for pest resistance management. However, the detoxification mechanism of .

Comprehensive analysis of differentially expressed genes in toll-like receptor signalling pathway: Insights into new-onset microscopic polyangiitis.

Objective: We aimed to elucidate the potential contributions of the toll-like receptor (TLR) signalling pathway and identify promising candidates for new-onset microscopic polyangiitis (MPA) using integrated bioinformatics analysis.

Methods: A PCR array was used to determine the expression profiles of TLR signalling-related genes in CD4T lymphocytes of individuals with new-onset MPA and healthy controls. Four genes were selected for validation through real-time quantitative polymerase chain reaction (RT-qPCR).

Vertebral Column Decancellation for Correcting Cervicothoracic Kyphotic Deformity in Patients With Ankylosing Spondylitis.

Objective: Surgery to correct the cervicothoracic kyphotic deformity in ankylosing spondylitis (AS) can be associated with serious neurovascular risks. According to the literature, there are no clinical reports documenting the use of vertebral column decancellation (VCD) in the treatment of cervicothoracic kyphotic deformity in patients with AS. The purpose of the present study was to retrospectively analyze and evaluate the effect of VCD on cervicothoracic kyphotic deformity in patients with AS.

Comparing outcomes for single-segment vertebral column decancellation performed at different vertebras in ankylosing spondylitis-an observational study.

Background: The surgical procedure of vertebral column decancellation (VCD) has been increasingly performed in orthopaedic surgery for those with spinal deformity. To investigate the results of single-segment VCD performed at different vertebra for correcting thoracolumbar kyphosis in ankylosing spondylitis (AS) and to guide the osteotomy strategy.

Methods: Eighty-six AS patients (77 males, 9 females) having thoracolumbar kyphosis underwent single-segment VCD (ranging from T12 to L3) between January 2016 and September 2019 were enrolled and divided into four groups according to the osteotomy vertebra: T12 in 9 cases (Group A), L1 in 15 cases (Group B), L2 in 47 cases (Group C), and L3 in 15 cases (Group D).

Association between ATG16L1 rs2241880(T300A) and rs4663421 and ANCA‑associated vasculitis in the Guangxi population of China: Propensity score matching analysis.

Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a rare autoimmune disease with an unclear pathogenesis. The present study investigated the associations between autophagy-related protein 16-like 1 (ATG16L1) rs2241880(T300A) and rs4663421 and AAV. A total of 177 patients with AAV and 216 healthy controls were included.

Short- and mid-term outcomes of the aortic root repair versus root replacement in acute type A aortic dissection.

Background: In patients with acute acute type A aortic dissection (ATAAD) requiring emergency surgery, the use of aortic root repair or replacement remains a topic of controversy. The purpose of this study was to evaluate the early and mid-term clinical outcomes after aortic root repair or replacement, and to provide a theoretical basis for such patients.

Methods: The study included 442 consecutive patients with ATAAD who underwent aortic root repair [n=227, repair group (RG)] or the Bentall procedure [n=215, Bentall group (BG)] at our hospital between December 2018 and December 2021.