Publications by authors named "Chao Wei"
Background: Growing evidence suggests a link between systemic lipopolysaccharide (LPS) exposure and worsening diabetic retinopathy (DR). This study aims to investigate DR's pathogenesis by analyzing LPS-related genes (LRGs) through bioinformatics.
Methods: The CTD database was utilized to identify LRGs.
Keratoconus (KC) is the most common ectatic corneal disease with unknown pathogenesis. This study aimed to investigate the role of methyltransferase-like enzyme 3 (METTL3) in KC pathogenesis. In the present study, we examined the levels of METTL3 and other N6-methyladenosine (mA) modification-related proteins in KC samples and human stromal keratocyte (HTK) cells stimulated by mechanical stretch (MS) using Western blotting and immunohistochemistry.
View Article and Find Full Text PDFRecent studies have revealed a structural role for DNA ligase 4 (Lig4) in the maintenance of a repair complex during non-homologous end joining (NHEJ) of DNA double-strand breaks. In cultured cell lines, catalytically inactive Lig4 can partially alleviate the severe DNA repair phenotypes observed in cells lacking Lig4. To study the structural role of Lig4 in vivo, a mouse strain harboring a point mutation to Lig4's catalytic site was generated.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers developed a new nanotechnology-based treatment called PC-DS NE, combining ferrous sulfate, diclofenac sodium, and proanthocyanidin, which has a small particle size and enables controlled drug release.
- * PC-DS NE demonstrated strong anti-inflammatory effects and successfully reduced corneal neovascularization in experimental models, suggesting it could be a potential new therapy for eye inflammatory diseases.
Article Synopsis
- Shaofu Zhuyu decoction is commonly used for gynecological conditions, but its effectiveness in treating endometriosis and the mechanisms behind it needed further investigation.
- Researchers analyzed its chemical makeup and tested its effects on endometriosis in mice, observing a significant reduction in the weight of ectopic lesions and improved gut microbiome diversity.
- The treatment also led to lower levels of fibrosis in lesions and changes in specific proteins and metabolic pathways, suggesting that it may alleviate endometriosis through regulating intestinal flora and reducing tissue scarring.
Flower color change, a common phenomenon that is important in pollination ecology, has intrigued scientists for decades. While previous flower color studies have mainly focused on color diversity among different plant species, our focus is on unraveling the mechanism of post-anthesis color change (PACC) and the molecular basis for its presence and absence, respectively, in two closely related species of Lotus, Lotus filicaulis and Lotus japonicus MG20. Metabolomic analysis reveals anthocyanins as the key metabolites responsible for the observed PACC.
View Article and Find Full Text PDFArticle Synopsis
Microplastic (MP) pollution prevalent in freshwater environments and jeopardizes the organisms living there. Dozens of studies have been conducted to investigate the harmful effects of microplastics on organisms. However, the most diverse and sensitive aquatic insects are often overlooked, also there is a lack of a comprehensive research exploring the toxicity of microplastics.
View Article and Find Full Text PDFBackground: Polycomb proteins are conventionally known as global repressors in cell fate determination. However, recent observations have shown their involvement in transcriptional activation, the mechanisms of which need further investigation.
Methods: Herein, multiple data from ChIP-seq, RNA-seq and HiChIP before or after RYBP depletion in embryonic stem cell (ESC), epidermal progenitor (EPC) and mesodermal cell (MEC) were analyzed.
This study presents an innovative approach to utilize coal gasification coarse slag (CGCS) for efficient and low-cost gallium extraction. Using a one-step acid leaching process, mesoporous silica with a surface area of 258 m/g and a pore volume of 0.15 cm/g was synthesized.
View Article and Find Full Text PDFArtificially Modified NK Cell-Based Synergistic Immuno-Gene-Photodynamic Therapy for Cancer.
Int J Nanomedicine
November 2024
Background: The immunotherapeutic approach utilizing Natural Killer (NK) cells for cancer treatment has garnered significant interest owing to its inherent cytotoxicity, immunomodulatory properties, demonstrated safety in in vivo studies. However, multiple immunosuppressive mechanisms in the tumor microenvironment (TME) suppress the anticancer effect of NK cells in the treatment of solid tumors. Herein, a smart NK cell drug delivery system (DDS) with photo-responsive and TME-responsive properties was designed.
View Article and Find Full Text PDFArticle Synopsis
- The study explores the transitions between rovibrational energy levels in gas molecules to improve gas laser output in mid to far-infrared ranges, highlighting insufficient research in laser dynamics.
- A new theoretical model using HBr-filled hollow-core fiber gas laser (HCFGL) incorporates 66 energy levels and considers vibrational and rotational relaxation, leading to more accurate laser threshold and efficiency estimates.
- The findings reveal concentrated gain at the entry point, causing thermal effects and population depletion, and show a consistent correlation between pump spectra output and rotational level distribution, aiding future HCFGL design and gas laser modeling.
Article Synopsis
- - **Genetic Basis of Migraine**: Migraine is largely polygenic, with many genetic variants identified through genome-wide association studies. Key mutations are linked to the TRPM8 channel, which senses cold but may have different activation mechanisms related to migraine.
- - **Role of Artemin and GFRα3**: The study explores how the neurotrophic factor artemin and its receptor GFRα3 influence migraine-related pain through their effects on TRPM8, potentially affecting cold sensitivity and pain responses in migraine models.
- - **Preclinical Findings**: Experiments on mice show that GFRα3 is crucial for mechanical sensitivity in migraine, as blocking artemin reduces migraine-like symptoms, highlighting its significance in
Global trends in ischemic stroke burden attributable to high BMI.
Medicine (Baltimore)
November 2024
We aimed to assess the worldwide burden of ischemic stroke (IS) associated with high body mass index (BMI) using data from the Global Burden of Disease 2019. This study examined the impact of high BMI on IS-related age-standardized death rates (ASDR) and disability-adjusted life years (DALYs). Estimated annual percentage changes (EAPC) is estimated annual percentage change.
View Article and Find Full Text PDFArticle Synopsis
- Quantum state tomography (QST) via local measurements is efficient but struggles with larger systems, prompting the development of a new method called parallel quantum state tomography (PQST).
- PQST minimizes the number of measurements needed and is more resilient to noise compared to traditional methods, demonstrating its practicality through experiments on superconducting qubit chips.
- The technique yielded high fidelity results, reconstructing complex states like six-qubit and nine-qubit W states efficiently, showcasing its potential for future applications in state reconstruction and characterization.
Article Synopsis
- * An analysis of 14 studies with nearly 27,400 participants found that plant-based, low-fat, and certain alternative diets significantly reduced ED risk, while high-protein low-fat diets and high-carb low-fat diets improved erectile function scores.
- * The findings suggest that diets rich in fruits, vegetables, and nuts, along with combined diet and exercise interventions, may enhance erectile function and offer promising management strategies for ED.
Article Synopsis
- Soil bacterial communities are vital for estuarine wetland functions, and their structure and function vary across different wetland types, influencing ecosystem health.
- * The study examined four wetland types in the Liaohe Estuary using advanced sequencing technology, revealing significant differences in soil properties and bacterial community characteristics.
- * The suaeda wetland showed the highest bacterial diversity, with key genera and pathways identified that play important roles in the carbon and nitrogen cycles, supporting better wetland management strategies.
Article Synopsis
- Neuroinflammation is important in a brain problem linked to sepsis, which is a serious body infection.
- Researchers studied tiny particles from the blood of sick mice to see how they affect inflammation in brain cells.
- They found that these particles can cause brain cells to release substances that might lead to cell death but not directly affect cell injury in tests done in a dish.
Article Synopsis
- A study was conducted to explore the long-term relationship between chronic kidney disease (CKD) and cognitive impairment (CI) in older Chinese adults, involving 16,515 participants over several years.
- Results indicated that individuals with CKD had a higher incidence rate of CI (11.46 per 1,000 person-years) compared to those without it (6.38 per 1,000 person-years), with hazard ratios showing a 56% increased risk of CI in CKD patients.
- Notably, CKD was found to accelerate the onset of CI by approximately 1.24 years, particularly impacting the middle-aged group (45-54 years), highlighting the need for early detection and intervention strategies.
Article Synopsis
- Migraine is influenced by genetics, with most cases being polygenic, which means they are linked to multiple genetic variants, particularly involving the TRPM8 channel, important for sensing cold.
- The study explores the role of the neurotrophic factor artemin and its receptor GFRα3 in migraine pain using rodent models, looking at how various treatments affect pain sensitivity.
- Results highlight the connection between GFRα3 and migraine-induced mechanical allodynia and show that blocking artemin can reduce migraine-like symptoms, indicating a significant neurotrophic pathway involvement.
PIWI-interacting RNAs (piRNAs) play critical and conserved roles in transposon silencing and gene regulation in the animal germline. Three distinct piRNA populations are present during mouse spermatogenesis: fetal piRNAs in fetal/perinatal testes, pre-pachytene and pachytene piRNAs in postnatal testes. PNLDC1 is required for piRNA 3' end maturation in multiple species.
View Article and Find Full Text PDFGlioblastoma is a Grade 4 primary brain tumor defined by therapy resistance, diffuse infiltration, and near-uniform lethality. The underlying mechanisms are unknown, and no treatment has been curative. Using a recently developed creatine kinase inhibitor (CKi), we explored the role of this inhibitor on GBM biology in vitro.
View Article and Find Full Text PDFArticle Synopsis
- Computer vision technology is increasingly applied in various fields, particularly for target detection and feature extraction to analyze motion data.
- In biology, there are challenges with data analysis for entities like bacteria and tumors, which opens avenues for further research.
- This paper presents a new optical MRI imaging method that utilizes computer vision to analyze the morphological features of kidney tumors, offering a non-invasive approach for clinical diagnosis and treatment.
Industrial byproduct gypsum (BPG) is a secondary product that is mainly composed of calcium sulfate discharged during industrial production. BPG primarily consists of desulfurized gypsum, phosphogypsum, and titanium gypsum, which account for 88% of the total BPG in China. The large-scale utilization of these three types of solid waste is crucial for the safe disposal of BPG.
View Article and Find Full Text PDF