Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip.

Developmental dysplasia of the hip (DDH) is a common musculoskeletal disorder characterized by a mismatch between acetabulum and femoral head. Mechanical force plays an important role during the occurrence and development of abnormities in acetabulum and femoral head. In this study, we established a mechanical force model named cyclic compressive stress (Ccs).

Investigation of Cross-Contamination and Misidentification of 278 Widely Used Tumor Cell Lines.

In recent years, biological research involving human cell lines has been rapidly developing in China. However, some of the cell lines are not authenticated before use. Therefore, misidentified and/or cross-contaminated cell lines are unfortunately commonplace.

Novel Bio-functional Magnesium Coating on Porous Ti6Al4V Orthopaedic Implants: In vitro and In vivo Study.

Titanium and its alloys with various porous structures are one of the most important metals used in orthopaedic implants due to favourable properties as replacement for hard tissues. However, surface modification is critical to improve the osteointegration of titanium and its alloys. In this study, a bioactive magnesium coating was successfully fabricated on porous Ti6Al4V by means of arc ion plating, which was proved with fine grain size and high film/substrate adhesion.

Dual Functionalities of Carbon Nanotube Films for Dendrite-Free and High Energy-High Power Lithium-Sulfur Batteries.

As a promising Li-metal battery, Li-S battery has an ultrahigh theoretical energy density of 2600 Wh kg. However, most of the previous work has mainly focused on tackling the "polysulfide shuttle" originating from the S cathode, while the dendrite problem coming from the Li-metal anode has often been overlooked. Herein, to solve the issues arising from both the cathode and anode simultaneously, we propose a novel cell configuration for the first time by inserting CNT films on both sides of the separator in Li-S batteries, in which the cathode-side CNT film works as a shield to suppress the "polysulfide shuttle" and the anode-side CNT film acts as a powerful shield to prevent the Li dendrite growth.

p53 participates in the protective effects of ischemic post-conditioning against OGD-reperfusion injury in primary cultured spinal cord neurons.

Spinal cord ischemia-reperfusion (I/R) injury is a severe clinical condition, while the mechanism is still not clarified and the therapeutic approach is limited. Ischemia post-conditioning (PC) has been found to have the protective effects against I/R injury in brain. Recently p53 has been reported to take part in the regulation and protection of I/R injury.

Selective remote esterification of 8-aminoquinoline amides via copper(ii)-catalyzed C(sp)-O cross-coupling reaction.

The remote C-O coupling of quinoline amides at the C5 position has been established using cheap and readily available copper catalyst under mild conditions. The positionally selective esterification protocol afforded C-O coupling products in moderate to excellent yields. Most importantly, this method may provide a potential alternative to the existing ways to build functionalized 5-hydroxyquinoline derivatives, which are utilized as pivotal intermediates in the synthesis of drug candidates.

Ferroelectric-Enhanced Polysulfide Trapping for Lithium-Sulfur Battery Improvement.

A brand new polysulfide entrapping strategy based on the ferroelectric effect has been demonstrated for the first time. By simply adding the nano-ferroelectrics (BaTiO nanoparticles) into the cathode, the heteropolar polysulfides can be anchored within the cathode due to the internal electric field originated from the spontaneous polarization BaTiO nanoparticles, and thus significantly improving the cycle stability of Li-S batteries.

Identification of QTL for Fiber Quality and Yield Traits Using Two Immortalized Backcross Populations in Upland Cotton.

Two immortalized backcross populations (DHBCF1s and JMBCF1s) were developed using a recombinant inbred line (RIL) population crossed with the two parents DH962 and Jimian5 (as the males), respectively. The fiber quality and yield component traits of the two backcross populations were phenotyped at four environments (two locations, two years). One hundred seventy-eight quantitative trait loci (QTL) were detected including 76 for fiber qualities and 102 for yield components, explaining 4.

20-meter underwater wireless optical communication link with 1.5 Gbps data rate.

The video streaming, data transmission, and remote control in underwater call for high speed (Gbps) communication link with a long channel length (~10 meters). We present a compact and low power consumption underwater wireless optical communication (UWOC) system utilizing a 450-nm laser diode (LD) and a Si avalanche photodetector. With the LD operating at a driving current of 80 mA with an optical power of 51.

c-Myc suppresses miR-451⊣YWTAZ/AKT axis via recruiting HDAC3 in acute myeloid leukemia.

Aberrant activation of c-Myc plays an important oncogenic role via regulating a series of coding and non-coding genes in acute myeloid leukemia (AML). Histone deacetylases (HDACs) can remove acetyl group from histone and regulate gene expression via changing chromatin structure. Here, we found miR-451 is abnormally down-regulated in AML patient samples; c-Myc recruits HDAC3 to form a transcriptional suppressor complex, co-localizes on the miR-451 promoter, epigenetically inhibits its transcription and finally induces its downregulation in AML.

The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia.

MicroRNA-22 (miR-22) is emerging as a critical regulator in organ development and various cancers. However, its role in normal hematopoiesis and leukaemogenesis remains unclear. Here, we detected its increased expression during monocyte/macrophage differentiation of HL-60, THP1 cells and CD34+ hematopoietic stem/progenitor cells, and confirmed that PU.

Toward Dendrite-Free Lithium Deposition via Structural and Interfacial Synergistic Effects of 3D Graphene@Ni Scaffold.

Owing to its ultrahigh specific capacity and low electrochemical potential, lithium (Li) metal is regarded as one of the most attractive anode materials for next-generation lithium batteries. Nevertheless, the commercialization of Li-metal-based rechargeable batteries (LiMBs) has been retarded by the uncontrollable growth of Li dendrites, as well as the resulting poor cycle stability and safety hazards. In this work, a 3D graphene@Ni scaffold has been proposed to accomplish dendrite-free Li deposition via structural and interfacial synergistic effects.

High-speed 405-nm superluminescent diode (SLD) with 807-MHz modulation bandwidth.

III-nitride LEDs are fundamental components for visible-light communication (VLC). However, the modulation bandwidth is inherently limited by the relatively long carrier lifetime. In this letter, we present the 405 nm emitting superluminescent diode (SLD) with tilted facet design on semipolar GaN substrate, showing a broad emission of ~9 nm at 20 mW optical power.

Response of plasmaspheric configuration to substorms revealed by Chang'e 3.

The Moon-based Extreme Ultraviolet Camera (EUVC) of the Chang'e 3 mission provides a global and instantaneous meridian view (side view) of the Earth's plasmasphere. The plasmasphere is one inner component of the whole magnetosphere, and the configuration of the plasmasphere is sensitive to magnetospheric activity (storms and substorms). However, the response of the plasmaspheric configuration to substorms is only partially understood, and the EUVC observations provide a good opportunity to investigate this issue.

Ultrabroad linewidth orange-emitting nanowires LED for high CRI laser-based white lighting and gigahertz communications.

Group-III-nitride laser diode (LD)-based solid-state lighting device has been demonstrated to be droop-free compared to light-emitting diodes (LEDs), and highly energy-efficient compared to that of the traditional incandescent and fluorescent white light systems. The YAG:Ce phosphor used in LD-based solid-state lighting, however, is associated with rapid degradation issue. An alternate phosphor/LD architecture, which is capable of sustaining high temperature, high power density, while still intensity- and bandwidth-tunable for high color-quality remained unexplored.

Hepatitis B vaccine response in obesity: A meta-analysis.

Background: Hepatitis B vaccination is critical in preventing hepatitis B virus (HBV) infection and transmission. However, the impact of obesity on immune response to hepatitis B vaccine remains unclear.

Methods: We performed a meta-analysis of the literature and summarized the results of immune response to hepatitis B vaccine among persons with and without obesity.

Synthesis and Biological Evaluation of Novel Carbohydrate-Derived Derivatives of Erlotinib.

Preclinical Research A series of novel carbohydrate-derived Erlotinib derivatives were prepared by the copper-catalyzed cycloaddition reaction of erlotinib with various azido-sugars. The structures of the newly synthesized compounds were characterized and their cytostatic effects evaluated in vitro on human cancer cell lines MDA-MB-231, HEPG-2, A549, and MCF-7 using an MTS assay. The novel erlotinib derivatives had the expected inhibitory effects on MDA-MB-231 and HEPG-2 cell llines.

Synthesis of C-glycosyl triazolyl quinoline-based fluorescent sensors for the detection of mercury ions.

A series of novel C-glycosyl triazolyl quinoline-based fluorescent sensors have been synthesized via click chemistry. It was found that novel sensors exhibited good selectivity for Hg(2+) over many other metal ions. The glucose framework was introduced to increase the water-solubility of the fluorescent sensors and broaden its application for the detection of Hg(II) in the water-solubility biological systems.

Differential gene expression in mouse spermatogonial stem cells and embryonic stem cells.

Mouse spermatogonial stem cells (mSSCs) may be reprogrammed to become pluripotent stem cells under in vitro culture conditions, due to epigenetic modifications, which are closely associated with the expression of transcription factors and epigenetic factors. Thus, this study was conducted to compare the gene expression of transcription factors and epigenetic factors in mSSCs and mouse embryonic stem cells (mESCs). Firstly, the freshly isolated mSSCs [mSSCs (f)] were enriched by magnetic-activated cell sorting with Thy1.

Droop-Free, Reliable, and High-Power InGaN/GaN Nanowire Light-Emitting Diodes for Monolithic Metal-Optoelectronics.

A droop-free nitride light-emitting diode (LED) with the capacity to operate beyond the "green gap" has been a subject of intense scientific and engineering interest. While several properties of nanowires on silicon make them promising for use in LED development, the high aspect ratio of individual nanowires and their laterally discontinuous features limit phonon transport and device performance. Here, we report on the monolithic integration of metal heat-sink and droop-free InGaN/GaN quantum-disks-in-nanowire LEDs emitting at ∼710 nm.

Better ILP-Based Approaches to Haplotype Assembly.

Haplotype assembly is to directly construct the haplotypes of an individual from sequence fragments (reads) of the individual. Although a number of programs have been designed for computing optimal or heuristic solutions to the haplotype assembly problem, computing an optimal solution may take days or even months while computing a heuristic solution usually requires a trade-off between speed and accuracy. This article refines a previously known integer linear programming-based (ILP-based) approach to the haplotype assembly problem in twofolds.

Gremlin2 Suppression Increases the BMP-2-Induced Osteogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells Via the BMP-2/Smad/Runx2 Signaling Pathway.

Osteoblasts are essential for maintaining skeletal architecture and modulating bone microenvironment homeostasis. From numerous associated investigations, the BMP-2 pathway has been well-defined as a vital positive modulator of bone homeostasis. Gremlin2 (Grem2) is a bone morphogenetic protein (BMP) antagonists.

Highly transparent, low-haze, hybrid cellulose nanopaper as electrodes for flexible electronics.

Paper is an excellent candidate to replace plastics as a substrate for flexible electronics due to its low cost, renewability and flexibility. Cellulose nanopaper (CNP), a new type of paper made of nanosized cellulose fibers, is a promising substrate material for transparent and flexible electrodes due to its potentially high transparency and high mechanical strength. Although CNP substrates can achieve high transparency, they are still characterized by high diffuse transmittance and small direct transmittance, resulting in high optical haze of the substrates.

High-brightness semipolar (2021¯) blue InGaN/GaN superluminescent diodes for droop-free solid-state lighting and visible-light communications.

A high-brightness, droop-free, and speckle-free InGaN/GaN quantum well blue superluminescent diode (SLD) was demonstrated on a semipolar (2021¯) GaN substrate. The 447-nm emitting SLD has a broad spectral linewidth of 6.3 nm at an optical power of 123 mW.