Objective: Calcaneal fracture fixation remains a challenging procedure in orthopedics, with computational tools increasingly aiding in the optimization of preoperative planning. To compare the biomechanical stability of intramedullary fixation and locking plate fixation for Sanders II and III calcaneal fractures by three-dimensional (3D) finite element analysis and to provide a theoretical basis for clinical application.
Methods: The Computed Tomography (CT) images were segmented using Mimics software (Materialise NV, Belgium) to identify the region of interest based on threshold segmentation.
Long-term durable remission in patients with B cell malignancies following chimeric antigen receptor (CAR)-T cell immunotherapy remains unsatisfactory, often due to antigen escape. Malignant B cell transformation and oncogenic growth relies on efficient ATP synthesis, although the underlying mechanisms remain unclear. Here, we report that YTHDF2 facilitates energy supply and antigen escape in B cell malignancies, and its overexpression alone is sufficient to cause B cell transformation and tumorigenesis.
View Article and Find Full Text PDFAn optical fiber surface plasmon resonance (SPR) sensor, leveraging hyperbolic metamaterials (HMMs) and pH-sensitive hydrogels, has been devised for pH detection in perspiration. Dispersion-tunable HMMs enable the sensor to transcend the inherent structural constraints of an optical fiber and enhance its refractive index (RI) sensitivity. pH-sensitive hydrogels exhibit diverse swelling behaviors due to varying ionization degrees of carboxyl groups under different solution pH conditions, leading to a notable RI change.
View Article and Find Full Text PDFThe quality of cellular products used in biological research can impact the accuracy of results. Epstein-Barr virus (EBV) is a latent virus that spreads extensively worldwide, and cell lines used in experiments may carry EBV and pose an infection risk. The presence of EBV in a single cell line can contaminate other cell lines used in the same laboratory, affecting experimental results.
View Article and Find Full Text PDFNutr Metab Cardiovasc Dis
November 2024
Objective: Isocitrate dehydrogenase (IDH) is the most important molecular marker of glioma and is highly correlated to the diagnosis, treatment, and prognosis of patients. We proposed a real-time diagnosis method for IDH status differentiation based on automatic analysis of intraoperative contrast-enhanced ultrasound (CEUS) video.
Methods: Inspired by the Time Intensity Curve (TIC) analysis of CEUS utilized in clinical practice, this paper proposed an automatic CEUS video analysis method called ATAN (Automatic TIC Analysis Network).
The generation of three-dimensional (3D) molecules based on target structures represents a cutting-edge challenge in drug discovery. Many existing approaches often produce molecules with invalid configurations, unphysical conformations, suboptimal drug-like qualities, limited synthesizability, and require extensive generation times. To address these challenges, we present 3DSMILES-GPT, a fully language-model-driven framework for 3D molecular generation that utilizes tokens exclusively.
View Article and Find Full Text PDFHerein, a photocatalytic strategy for the synthesis of secondary alcohols by nucleophilic addition of an alkene with an aldehyde is described. This operationally simple methodology opens an approach for the synthesis of alcohols using commercially available reagents in moderate to excellent yields. Mechanistic studies indicate that the formation of the radical anion from alkene via single-electron transfer is the key step in this reaction.
View Article and Find Full Text PDFSurface plasmon resonance (SPR) optical fiber sensors are appealing for biomolecular detection due to their inherent characteristics such as flexibility, real-time performance, and high sensitivity. Concurrently, incorporating SPR sensors into wearable devices has emerged as a significant strategy. However, the majority of traditional SPR optical fiber sensors utilize spectrometers for optical readout, which leads to a relatively bulky overall size of the sensing system.
View Article and Find Full Text PDFAim: Although neuroticism has a negative impact on burnout among healthcare workers, there is little research exploring the specific interactions between different components of burnout and neuroticism. This study aims to investigate this relationship among nurses in Emergency Departments (ED) through network analysis method (NAM).
Design: A cross-sectional investigative survey was conducted.
Background: The prognosis of critically ill patients is closely linked to their gastrointestinal (GI) function. The acute GI injury (AGI) grading system, established in 2012, is extensively utilized to evaluate GI dysfunction and forecast outcomes in clinical settings. In 2021, the GI dysfunction score (GIDS) was developed, building on the AGI grading system, to enhance the accuracy of GI dysfunction severity assessment, improve prognostic predictions, reduce subjectivity, and increase reproducibility.
View Article and Find Full Text PDFRadiation-free photonic bound states in the continuum (BIC) in metasurfaces allow ultrahigh quality (Q) factor and strongly confined mode volume, which are extremely advantageous in the development of ultrasensitive microcavity sensors. However, the conventional isolated BICs are susceptible to failure due to symmetry breaking caused by fabrication imperfection and nonzero incident angle. Here, we propose a silicon nitride-based metasurface with multiple BIC merging.
View Article and Find Full Text PDFWith the deployment of the fifth-generation (5 G) emerging technologies, such as massive multiple-input multiple-output (mMIMO), conventional mobile fronthaul (FH) schemes based on Common Public Radio Interface (CPRI) are limited in their abilities to support ultra-high data rate, large bandwidth and massive connectivity. This has led to a growing demand for alternative solutions that can better fulfill these requirements. Visible light communication (VLC) has recently gained increasing research interest as a potential complementary technology for beyond-5 G communication, offering advantages such as unlicensed and abundant spectrum, high bandwidth and cost-efficiency.
View Article and Find Full Text PDFHepatitis E virus (HEV) is one of the major etiologies for acute liver failure. This multicenter retrospective cohort study aimed to investigate the associations of lipid profiles with the risk of HEV-related acute liver failure (HEV-ALF) among hospitalized patients with acute hepatitis E. A total of 1061 participants were obtained from three tertiary medical centers in Jiangsu, China, between February 2018 and May 2024.
View Article and Find Full Text PDFIn this study, a strain with good exopolysaccharide (EPS)-producing ability was isolated from the fermented Benincasa hispida and identified as Lactiplantibacillus plantarum Z-1. Its EPS production was further improved by HO stress under optimized culture conditions, increasing from 180 ± 0.45 mg/L to 409.
View Article and Find Full Text PDFBMC Public Health
November 2024
Background: The harmonious cognitive alignment among various netizen groups is pivotal for the spread and amplification of online rumors. This alignment, characterized by shared cognitive inclinations, fosters uniformity in attitudes and perspectives, thereby precipitating synchronized engagement in the dissemination of such rumors. Notably, discernible disparities emerge in group cognition as different types of rumors pertaining to the same event propagate.
View Article and Find Full Text PDFTumor metastasis is responsible for 90 % of cancer-associated deaths, and its early detection may decrease the likelihood of mortality. Studies have demonstrated that metastasis results from the interaction between "seeds" (tumor cells) and "soil" (pre-metastatic niche, PMN). As the first and most abundant immune cells to be recruited to PMN, neutrophils play a key role in the ultimate formation of metastatic foci through mechanisms such as supporting tumor cell growth, promoting angiogenesis, and shaping an immune-suppressive microenvironment.
View Article and Find Full Text PDFComplex oxide thin films cover a range of physical properties and multifunctionalities that are critical for logic, memory, and optical devices. Typically, the high-quality epitaxial growth of these complex oxide thin films requires single crystalline oxide substrates such as SrTiO (STO), MgO, LaAlO, a-AlO and many others. Recent successes in transferring these complex oxides as free-standing films not only offer great opportunities in integrating complex oxides on other devices, but also present enormous opportunities in recycling the deposited substrates after transfer for cost-effective and sustainable processing of complex oxide thin films.
View Article and Find Full Text PDFThe high incidence and mortality rate of colorectal cancer have become a significant global health burden. Chemotherapy has been the traditional treatment for colorectal cancer and has demonstrated promising antitumor effects, leading to significant improvements in patient survival. However, the development of chemoresistance poses a major challenge during chemotherapy in colorectal cancer, significantly impeding treatment efficacy and affecting patient prognosis.
View Article and Find Full Text PDFA biomass-based catalyst, CuO@CS-400, was employed as an excellent recyclable heterogeneous catalyst to realize the sulfonylation reaction of aniline derivatives with sodium sulfinates. Various substrates were compatible, giving the desired products moderate to good yields at room temperature. In addition, this heterogeneous copper catalyst was also easy to recover and was recyclable up to five times without considerably deteriorating in catalytic efficiency.
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