Effect of Metastable Intermolecular Composites on the Thermal Decomposition of Glycidyl Azide Polymer Energetic Thermoplastic Elastomer.

Glycidyl azide polymer energetic thermoplastic elastomer (GAP-ETPE) has become a research hotspot due to its excellent comprehensive performance. In this paper, metastable intermolecular energetic nanocomposites (MICs) were prepared by a simple and safe method, and the catalytic performance for decomposition of GAP-ETPE was studied. An X-ray diffraction (XRD) analysis showed that the MICs exhibited specific crystal formation, which proved that the MICs were successfully prepared.

Design of PDMS/PAN composite membranes with ultra-interfacial stability layer integration.

The interfacial interaction between the selective layer and porous substrate directly determines the separation performance and service lifetime of functional composite membranes. Till now, almost all reported polymeric selective layers are physically in contact with the substrate, which is unsatisfactory for long-term operation. Herein, we introduced a functional composite membrane with ultra-interfacial stability layer integration between the polydimethylsiloxane selective layer and polyacrylonitrile substrate, where a facile light-triggered copolymerization achieved their covalent bonding.

Punicalin attenuates LPS-induced acute lung injury by inhibiting inflammatory cytokine production and MAPK/NF-κB signaling in mice.

Background: Acute lung injury (ALI) remains a significant cause of morbidity and mortality in critically ill patients. Novel therapies interfering with the inflammatory response has been an area of focus for infectious disease treatment. Punicalin has shown strong anti-inflammatory and antioxidative properties; however, its effect in ALI has not been previously explored.

Personality, Preoperative Anxiety, and Postoperative Outcomes: A Review.

Research has shown that personality is associated with anxiety levels in the general population. However, little is known about the relationship between personality and preoperative anxiety and the subsequent health outcomes in patients undergoing surgery. Therefore, this review aimed to identify studies that explored the relationship between personality traits and preoperative anxiety, as well as their association with postoperative outcomes.

3MCor: an integrative web server for metabolome-microbiome-metadata correlation analysis.

Motivation: The metabolome and microbiome disorders are highly associated with human health, and there are great demands for dual-omics interaction analysis. Here, we designed and developed an integrative platform, 3MCor, for metabolome and microbiome correlation analysis under the instruction of phenotype and with the consideration of confounders.

Results: Many traditional and novel correlation analysis methods were integrated for intra- and inter-correlation analysis.

Altered bile acid glycine : taurine ratio in the progression of chronic liver disease.

Background And Aim: The onset and progression of chronic liver disease (CLD) is a multistage process spanning years or several decades. Some bile acid (BA) features are identified as indicators for CLD progression. However, BAs are highly influenced by various factors and are stage and/or population specific.

Bile Acid Profiles Are Distinct among Patients with Different Etiologies of Chronic Liver Disease.

A significant increase of bile acid (BA) levels has been recognized as a general metabolic phenotype of diverse liver diseases. Monitoring of BA profiles has been proposed for etiology differentiation on liver injury. Here, we quantitatively profiled serum BAs of healthy controls and 719 patients with chronic liver disease of five etiologies, hepatitis B virus (HBV), hepatitis C virus (HCV), nonalcoholic steatohepatitis (NASH), alcohol-induced liver disease (ALD), and primary biliary cirrhosis (PBC), and investigated the generality and specificity of different etiologies.

Diagnosis of Fibrosis Using Blood Markers and Logistic Regression in Southeast Asian Patients With Non-alcoholic Fatty Liver Disease.

Non-alcoholic fatty liver disease (NAFLD) is one of the main causes of fibrosis. Liver biopsy remains the gold standard for the confirmation of fibrosis in NAFLD patients. Effective and non-invasive diagnosis of advanced fibrosis is essential to disease surveillance and treatment decisions.

Facile mass preparation and characterization of Al/copper ferrites metastable intermolecular energetic nanocomposites.

In the present work, a novel Al/copper ferrites metastable intermolecular energetic nanocomposite was prepared by a simple and mild sol-gel method followed by low temperature calcination, and characterized by various analytical techniques. The X-ray diffraction (XRD) analysis suggests that the products contain crystal forms of aluminum and spinel-type ferrite crystal forms which are CuFeO with many crystal defects. The scanning electron microscopy (SEM) and nitrogen adsorption-desorption analyses reveal that the prepared Al/copper ferrites are mesoporous structures with large specific surface areas of up to 184.

The Scale, Collections, and Biospecimen Distribution of Grade A Tertiary Hospital Biobanks in China: A National Survey.

Chinese clinical biobanks were built rapidly in grade A tertiary hospitals. However, the general information of biorepositories in China remained largely unknown. The aim of this study was to investigate the size, collections, biospecimens distribution and other characteristics of Chinese biobanks in grade A tertiary hospitals.

Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling.

Theabrownin is one of the most bioactive compounds in Pu-erh tea. Our previous study revealed that the hypocholesterolemic effect of theabrownin was mediated by the modulation of bile salt hydrolase (BSH)-enriched gut microbiota and bile acid metabolism. In this study, we demonstrated that theabrownin ameliorated high-fat-diet (HFD)-induced obesity by modifying gut microbiota, especially those with 7α-dehydroxylation on the species level, and these changed microbes were positively correlated with secondary bile acid (BA) metabolism.

Computational modeling reveals the relationship between intrinsic failure properties and uniaxial biomechanical behavior of arterial tissue.

Biomechanical failure of the artery wall can lead to rupture, a catastrophic event with a high rate of mortality. Thus, there is a pressing need to understand failure behavior of the arterial wall. Uniaxial testing remains the most common experimental technique to assess tissue failure properties.

A Uniaxial Testing Approach for Consistent Failure in Vascular Tissues.

Although uniaxial tensile testing is commonly used to evaluate failure properties of vascular tissue, there is no established protocol for specimen shape or gripping method. Large percentages of specimens are reported to fail near the clamp and can potentially confound the studies, or, if discarded will result in sample waste. The objective of this study is to identify sample geometry and clamping conditions that can achieve consistent failure in the midregion of small arterial specimens, even for vessels from older individuals.