Knowledge, attitude, and practice towards knee osteoarthritis: a regional study in Chinese patients.

Introduction: Given the chronic nature of knee osteoarthritis and its reliance on self-management, patients' knowledge, attitudes, and practice (KAP) significantly influence their ability to effectively manage knee osteoarthritis. This study aimed to investigate patients' KAP towards knee osteoarthritis.

Methods: This cross-sectional survey was conducted among patients with knee osteoarthritis, using a self-designed questionnaire.

Patterns and outcomes of early and late recurrence after hepatectomy for hepatocellular carcinoma with microvascular invasion: a multicenter study in China.

Background: A few studies focus on the long-term outcomes and surveillance strategies for patients with hepatocellular carcinoma (HCC) and microvascular invasion (MVI) who experience postoperative recurrence. The aim of this study was to explore the patterns and prognosis of early and late recurrence (ER and LR) after hepatectomy of such patients.

Methods: Consecutive patients with HCC and MVI after hepatectomy from 26 centers in China from 2009 to 2020 were included.

Anode Alchemy on Multiscale: Engineering from Intrinsic Activity to Impedance Optimization for Efficient Water Electrolysis.

The past decade has seen significant progress in proton exchange membrane water electrolyzers (PEMWE), but the growing demand for cost-effective electrolytic hydrogen pushes for higher efficiency at lower costs. As a complex system, the performance of PEMWE is governed by a combination of multiscale factors. This review summarizes the latest progress from quantum to macroscopic scales.

Significance of left ventricular strain in cardiac magnetic resonance for short-term prognosis in pediatric patients with acute lymphoblastic leukemia.

Background: The survival rate of pediatric leukemia patients has remarkably increased. Early identification of cardiotoxicity associated with chemotherapy and the detection of prognostic factors are essential for effective patient management.

Objective: To evaluate the prognostic value of parameters assessed by cardiac magnetic resonance imaging (MRI) in pediatric patients with acute lymphoblastic leukemia (ALL).

Graphene quantum dots as supramolecular linkers in metal organic frameworks for constructing metal atom electrocatalysts.

A new strategy is developed to stabilize single cobalt sites by covalent linking between metal and N-doped graphene quantum dots (N-GQDs) confined within the pores of zeolitic imidazolate frameworks (ZIFs). The incorporation of N-GQDs not only facilitates the formation of abundant active sites but also promotes their accessibility.

An update on regulation and function of G protein-coupled receptors in cancer: A promising strategy for cancer therapy.

G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that play a crucial role in signal transduction and cellular communication. GPCR proteins are involved in a wide range of physiological processes, including cell growth, migration, and survival. Dysregulation of GPCR protein expression has been implicated in the pathogenesis of various diseases, including cancer, and GPCR proteins have been shown to modulate these processes in various types of cancer, highlighting their importance as potential therapeutic targets.

GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway.

Background: Ovarian cancer (OC) progression is one of the commonest cause of female cancer death. While treatments in clinic includes primary surgery and targeted chemotherapy, curative and survival trends in OC have not significantly improved. Thus, further investigation of the mechanisms regarding OC carcinogenesis and discovery of novel targets is of great importance.

Effect of electroacupuncture on discomfort in patients undergoing colonoscopy: protocol for a multicentre, randomised, controlled clinical trial.

Introduction: Colonoscopy is currently the most commonly used and effective method for early detection, diagnosis and treatment of tumours of the colon and rectum. However, similar to other invasive procedures, it is associated with adverse reactions such as pain and abdominal distension. Electroacupuncture (EA) has been proposed as a potential treatment for relieving this discomfort; however, there is limited evidence supporting its efficacy.

Radiation-induced nasopharyngeal necrosis combined with local recurrence in nasopharyngeal carcinoma: diagnosis and treatment strategies.

Background: To identify the diagnosis and treatment strategies by analyzing the clinical characteristics and treatment methods of RNNCLR.

Methods: A total of 210 patients pathologically diagnosed with RNNCLR were retrospectively included. Clinical characteristics, MRI features, treatment methods, and survival outcomes were analyzed.

Neutrophil diversity and function in health and disease.

Neutrophils, the most abundant type of granulocyte, are widely recognized as one of the pivotal contributors to the acute inflammatory response. Initially, neutrophils were considered the mobile infantry of the innate immune system, tasked with the immediate response to invading pathogens. However, recent studies have demonstrated that neutrophils are versatile cells, capable of regulating various biological processes and impacting both human health and disease.

Construction of AML prognostic model with CYP2E1 and GALNT12 biomarkers based on golgi- associated genes.

Acute myeloid leukaemia (AML) was originally an aggressive malignancy of the bone marrow and one of the deadliest forms of acute leukaemia. The 5-year mortality benefit for patients with AML was only 28.3%.

Spatial and temporal distribution of ribosomes in single cells reveals aging differences between old and new daughters of .

Lineages of rod-shaped bacteria such as exhibit a temporal decline in elongation rate in a manner comparable to cellular or biological aging. The effect results from the production of asymmetrical daughters, one with a lower elongation rate, by the division of a mother cell. The slower daughter compared to the faster daughter, denoted respectively as the old and new daughters, has more aggregates of damaged proteins and fewer expressed gene products.

Neutrophil extracellular traps in tumor progression of gynecologic cancers.

This article delves into the intricate interplay between tumors, particularly gynecologic malignancies, and neutrophil extracellular traps (NETs). The relationship between tumors, specifically gynecologic malignancies, and NETs is a multifaceted and pivotal area of study. Neutrophils, pivotal components of the immune system, are tasked with combating foreign invaders.

Quantum Coherence Control at Temperatures up to 1400 K.

Coherent quantum control at high temperatures is important for expanding the quantum world and is useful for applying quantum technologies to realistic environments. Quantum control of spins in diamond has been demonstrated near 1000 K, with the spins polarized and read out at room temperature and controlled at elevated temperatures by rapid heating and cooling. Further increase of the working temperature is challenging due to fast spin relaxation in comparison with the heating and cooling rates.

Copper aggravated synaptic damage after traumatic brain injury by downregulating BNIP3-mediated mitophagy.

Synaptic damage is a crucial pathological process in traumatic brain injury. However, the mechanisms driving this process remain poorly understood. In this report, we demonstrate that the accumulation of damaged mitochondria, resulting from impaired mitphagy, plays a significant role in causing synaptic damage.

Catalytic Edges in One-Dimensional Covalent Organic Frameworks for the Oxygen Reduction Reaction.

Metal-free covalent organic frameworks (COFs) are employed in oxygen reduction reactions (ORR) because of their diverse structural units and controllable catalytic sites, and the edge sites have high catalytic activity than the basal sites. However, it is still challenge to modulate the edge sites in COFs, because the extended frameworks in two- or three-dimensional topologies resulted in limited edge parts. In this study, we have demonstrated the edge site modulation engineering based on one dimensional (1D) COFs to catalyze the ORR, which featured distinct edge groups-carbonyl, diaminopyrazine, phenylimidazole, and benzaldehyde imidazole units.

Operando Decoding Ion-Conductive Switch in Stimuli-Responsive Hydrogel by Nanodiamond-Based Quantum Sensing.

Thermal-responsive hydrogels are developed as ion-conductive switchs for energy storage devices, however, the molecule mechanism of switch on/off remains unclear. Here, poly(N-isopropylacrylamide-co-acrylamide) hydrogel is synthesized as a model material and nanodiamond (ND) based quantum sensing for phase change study is developed. First, micro-scale phase separation with cross-linked mesh structure after sol-gel transition is visualized in situ and water molecules are trapped by polymer chains and on a chemically "frozen" state.

Long non-coding RNA LNC-POTEM-4 promotes HCC progression via the LNC-POTEM-4/miR-149-5p/Wnt4 signaling axis.

Information on the potential role of the long non-coding RNA LNC-POTEM-4 in cancer progression is limited. Our preliminary study found that LNC-POTEM-4 was overexpressed in hepatocellular carcinoma (HCC) tissues, which led us to further investigate the biological function and molecular mechanism of LNC-POTEM-4 in HCC development. LNC-POTEM-4 expression in HCC tissues was examined using transcriptome sequencing and quantitative reverse transcription PCR.

SCG2 mediates blood-brain barrier dysfunction and schizophrenia-like behaviors after traumatic brain injury.

Traumatic brain injury (TBI), which is characterized by acute neurological dysfunction, is also one of the most widely recognized environmental risk factors for various neurological and psychiatric disorders. However, the role of TBI in neurological perturbation and the mechanisms underlying these disorders remain unknown. We evaluated transcriptional changes in cells of the frontal cortex after TBI by exploiting single-cell RNA sequencing (scRNA-Seq).