Publications by authors named "Chao Hsiun Tang"
Estimate patient counts, treatment patterns and outcomes of a subset of patients with early breast cancer (EBC) presenting with hormone receptor positive, human epidermal growth factor receptor 2 negative, node positive features, who are at high-risk of recurrence, in Taiwan. Data from Taiwan's National Health Insurance Research Database and Taiwan Cancer Registry from 1 January 2011 to 31 December 2020 were analyzed. There were 4500 patients with high-risk EBC (10.
View Article and Find Full Text PDFWe conducted a retrospective population-based, matched cohort study using the National Health Insurance Research Database to estimate healthcare resource utilisation (HRU) and costs in patients with newly diagnosed AL amyloidosis in Taiwan. Cases were matched 10:1 by age, sex, and area of residence to patients without AL amyloidosis (comparators) randomly selected from the database during the same time period. Annual all-cause HRU and costs for 3 years were quantified.
View Article and Find Full Text PDFObjectives: This study investigated the epidemiology, treatment patterns, and resource utilization in patients with alopecia areata (AA) in Taiwan using the National Health Insurance Research Database. AA severity was determined by treatment use and diagnostic codes in the year after enrollment (including corticosteroids, systemic immunosuppressants, topical immunotherapy, and phototherapy).
Methods: The cross-sectional analysis was conducted to estimate the incidence and prevalence of AA from 2016 to 2020.
Background: Thrombosis with thrombocytopenia syndrome (TTS) is a very rare prothrombotic disorder that is a safety concern for some COVID-19 vaccines. We aimed to devise a case definition to estimate the incidence of thrombosis with thrombocytopenia as a proxy for TTS in a national insurance claims database.
Methods: We conducted a retrospective observational study using the National Health Insurance Research Database (NHIRD) in Taiwan over the three-year period prior to the SARS-COV-2 pandemic (2017-2019).
Background: Schizophrenia is one of the leading causes of disability. Paliperidone palmitate once-monthly injection (PP1M) was developed to provide consistent drug delivery and improve medication adherence for maintenance treatment. It is well known that patients with schizophrenia have higher cardiovascular risks, however little is known about the cardiovascular risks of patients with schizophrenia treated with PP1M in Asia.
View Article and Find Full Text PDFBackground: Connections between long-term use of topical corticosteroids (TCSs) of varying potency and osteoporosis and major osteoporotic fracture (MOF) are unclear. Susceptibility to adverse bone effects of TCSs in different sex, age and ethnic groups is unknown too.
Objectives: To demonstrate the association between cumulative dose of TCSs of varying potency and osteoporosis and MOF in Taiwanese population, with stratified analysis of sex and age.
Article Synopsis
- Bullous pemphigoid occurs more frequently in patients undergoing chronic dialysis, indicating that these individuals are at a significantly higher risk for developing this condition compared to a matched control group.
- A study analyzing data from Taiwan's National Health Insurance Research Database found that the incidence rate of bullous pemphigoid in dialysis patients was over two times higher than in controls, with younger dialysis patients (under 75 years) facing an even greater risk.
- In contrast, chronic dialysis did not appear to significantly increase the risk for pemphigus, emphasizing the need for physicians to monitor dialysis patients specifically for bullous pemphigoid.
Background: We estimated healthcare resource utilization (HRU) and costs in patients with generalized myasthenia gravis (gMG) in Taiwan.
Methods: This retrospective population-based, matched cohort study used the National Health Insurance Research Database to identify prevalent patients with gMG (cases) in 2019. In total, 2537 cases were matched (1:4) by age, sex, and urbanization level to 10148 randomly selected patients without gMG (comparators).
Background: The prevalence of myasthenia gravis is increasing in many countries, including Asia. As treatment options expand, population-based information about the disease burden can inform health technology assessments.
Methods: We conducted a population-based retrospective cohort study using the Taiwan National Healthcare Insurance Research database and Death Registry to describe the epidemiology, disease burden and treatment patterns of generalized myasthenia gravis (gMG) from 2009 to 2019.
Article Synopsis
- The study examines real-world treatment retention for paliperidone palmitate (PP3M) in schizophrenia patients, highlighting the impact of prior treatment duration and proper initiation.
- PP3M retention rates were found to decline over 24 months, yet most patients received subsequent doses after initial treatments.
- Higher adherence to PP3M treatment in the first year correlated with a reduced risk of psychiatric hospitalization over the following years.
Importance: The cancer risks associated with treatment with topical calcineurin inhibitors (TCIs) in patients with atopic dermatitis (AD) remain controversial, and limited evidence exists regarding the cancer risks among patients with AD treated with TCIs in Asian populations.
Objectives: This study identified the association between TCI use and the risks of developing all cancers, lymphoma, skin cancers, and other cancers.
Design: This study was a nationwide, population-based, retrospective cohort study.
Article Synopsis
- Depression raises the chances of work disability, sick leave, unemployment, and early retirement, particularly among depressive patients.
- A study in Taiwan analyzed 3,673 depressive patients over up to 12 years, revealing they were 1.24 times more likely to become non-income earners than controls.
- Factors such as being younger, having a lower income, living in urban areas, and regional differences increased the risk of job loss among these patients, yet most still managed to stay employed.
Atopic dermatitis is a prevalent inflammatory skin disease that manifests clinically as pruritus and eczema. Severe forms of atopic dermatitis can be chronic and relapsing or associated with other dermatological complications and comorbidities, resulting in lifelong impacts across multiple aspects for patients. This study was conducted to calculate the atopic dermatitis-related economic burden in Taiwan.
View Article and Find Full Text PDFIntroduction: The objective of this study was to conduct a retrospective analysis to understand the patient profile, treatment patterns, healthcare resource utilization, and cost of atopic dermatitis (AD) of patients eligible for targeted therapy in Taiwan.
Methods: A retrospective, claims-based analysis was undertaken using Taiwan's National Health Insurance Research Database from 01 January 2014 to 31 December 2017. Patients aged ≥ 2 years and with at least one diagnosis code for AD during 2015 were identified.
The incidence rate of AL (light-chain) amyloidosis is not known in Asia. We conducted a retrospective cohort study using the Taiwan National Healthcare Insurance Research database and Death Registry to estimate incidence and all-cause case fatality rates, and characteristics of patients with AL amyloidosis in Taiwan. All patients with confirmed, newly diagnosed AL amyloidosis from 01-Jan-2016 until 31-Dec-2019 were enrolled and followed up until dis-enrolment, death or study end (31-Dec-2019).
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- The study analyzed population-based data in Taiwan from 2010 to 2017 to assess treatment-resistant depression (TRD) among patients with unipolar depression receiving adequate treatment.
- Approximately 37.1% of patients with adequately treated depression (PTD) were found to have TRD, with the average time from PTD to TRD being about one year.
- Results indicated that TRD patients, primarily women and middle-aged, utilized significantly more medical resources compared to those without TRD.
Objectives: This study assessed risk adjustment performance of six comorbidity indices in two categories of comorbidity measures: diagnosis-based comorbidity indices and medication-based ones in patients with chronic obstructive pulmonary disease (COPD).
Methods: This was a population-based retrospective cohort study. Data used in this study were sourced from the Taiwan National Health Insurance Research Database.
Article Synopsis
- The study investigates the effectiveness and adherence to biologics for treating moderate-to-severe psoriasis in Taiwan using data from the National Health Insurance Research Database.
- A total of 1,397 patients were analyzed, revealing that ustekinumab had the highest persistence rates (94.2% at 1 year and 84.9% at 2 years) compared to adalimumab and etanercept.
- Results indicated that patients on ustekinumab had a significantly lower risk of treatment discontinuation than those on adalimumab and etanercept, highlighting its potential as a preferred treatment option.
Article Synopsis
- This study explored the relationship between the severity of atopic dermatitis (AD) and levels of anxiety and depression, measured by the Hospital Anxiety and Depression Scale (HADS), in patients from Taiwan.
- Patients with moderate-to-severe AD showed significantly higher rates of borderline and abnormal anxiety/depression scores compared to those with milder forms of the condition.
- Limitations include the study's cross-sectional nature, the lack of comprehensive baseline data on previous health issues, and the need for more rigorous psychiatric assessments for accurate evaluation.
Background: Atopic dermatitis (AD) is a common chronic skin disease. Only relatively scant studies from Asian countries have attempted to quantify AD-associated healthcare utilization and costs by using population-based databases. This study aims to evaluate the AD-associated annual healthcare utilization and costs in Taiwan.
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