Zn-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy.

Osteoarthritis (OA) is a type of joint disease that influences millions of individuals. Regrettably, effective treatment for OA is currently unavailable. The challenge lies in the deep location of chondrocytes within the dense cartilage matrix that hinders the delivery and efficiency of clinical OA drugs.

Bioactive Nanoparticle-Embedded Micro/Nanofibrous Dressing with Improved Angiogenesis and Immunoregulation for Facilitating Burn Wound Healing.

In the context of severe burn injuries, the presence of excessive reactive oxygen species (ROS), prolonged microbial infection, and compromised angiogenesis can contribute to the metabolic reprogramming of macrophages, resulting in a dysregulated inflammatory response that hinders the healing process. In this study, cerium oxide nanoparticles (CeNPs) are encapsulated within a silk fibroin-poly(e-caprolactone) polymer to create an electrospun PSF/CeNPs nanofiber membrane (PSF/membrane). This membrane is further modified through the addition of an angiopoietin-1 mimetic peptide, QHREDGS, resulting in the formation of QPSF/CeNPs (QHREDGS modified PSF/CeNPs membrane).