Functional Characterisation of Three Glycine -Acyltransferase Variants and the Effect on Glycine Conjugation to Benzoyl-CoA.

The glycine conjugation pathway in humans is involved in the metabolism of natural substrates and the detoxification of xenobiotics. The interactions between the various substrates in this pathway and their competition for the pathway enzymes are currently unknown. The pathway consists of a mitochondrial xenobiotic/medium-chain fatty acid: coenzyme A (CoA) ligase (ACSM2B) and glycine -acyltransferase (GLYAT).