Publications by authors named "Chante D Mayer"
Article Synopsis
- Research on improving brain tumor immunotherapy focuses on understanding how T cells enter the tumor area from the bloodstream, specifically through a type of blood vessel called peritumoral venous vessels (PVVs).
- In mouse models of intracranial melanoma, T cells were found to preferentially move through PVVs, while other blood vessels were less involved in T cell recruitment.
- Treatment with immune checkpoint inhibitors, like anti-PD-1/CTLA-4, boosted T cell movement from PVVs to tumors, slowing tumor growth, and highlighting the importance of the ICAM-1 molecule in this process, which could have implications for other brain diseases as well.
Unlabelled: Crossing the blood-brain barrier is a crucial, rate-limiting step of brain metastasis. Understanding of the mechanisms of cancer cell extravasation from brain microcapillaries is limited as the underlying cellular and molecular processes cannot be adequately investigated using in vitro models and endpoint in vivo experiments. Using ultrastructural and functional imaging, we demonstrate that dynamic changes of activated brain microcapillaries promote the mandatory first steps of brain colonization.
View Article and Find Full Text PDF