Association Between Nursing Support Levels and Effectiveness of Golimumab in the Management of Patients with Rheumatologic Diseases.

Introduction: The main objective of this study was to assess the level of nursing support received by biologic-naïve rheumatological patients treated with golimumab during their first cycle.

Methods: Adult patients (N = 119; aged 46.9 ± 13.

Trade-off between capacity and precision in visuospatial working memory.

Limitations in the performance of working memory (WM) tasks have been characterized in terms of the number of items retained (capacity) and in terms of the precision with which the information is retained. The neural mechanisms behind these limitations are still unclear. Here we used a biological constrained computational model to study the capacity and precision of visuospatial WM.

Reward modulates adaptations to conflict.

Both cognitive conflict (e.g. Verguts & Notebaert, 2009) and reward signals (e.

The neural basis of implicit perceptual sequence learning.

The present fMRI study investigated the neural areas involved in implicit perceptual sequence learning. To obtain more insight in the functional contributions of the brain areas, we tracked both the behavioral and neural time course of the learning process, using a perceptual serial color matching task. Next, to investigate whether the neural time course was specific for perceptual information, imaging results were compared to the results of implicit motor sequence learning, previously investigated using an identical serial color matching task (Gheysen et al.

Stages of nonsymbolic number processing in occipitoparietal cortex disentangled by fMRI adaptation.

The neurobiological mechanisms of nonsymbolic number processing in humans are still unclear. Computational modeling proposed three successive stages: first, the spatial location of objects is stored in an object location map; second, this information is transformed into a numerical summation code; third, this summation code is transformed to a number-selective code. Here, we used fMRI-adaptation to identify these three stages and their relative anatomical location.

Influence of the COMT genotype on working memory and brain activity changes during development.

Background: The Valine158Methionine (Val158Met) polymorphism of the COMT gene leads to lower enzymatic activity and higher dopamine availability in Met carriers. The Met allele is associated with better performance and reduced prefrontal cortex activation during working memory (WM) tasks in adults. Dopaminergic system changes during adolescence may lead to a reduction of basal dopamine levels, potentially affecting Met allele benefits during development.

Hippocampal contribution to early and later stages of implicit motor sequence learning.

Implicit motor sequence learning refers to an important human ability to acquire new motor skills through the repeated performance of a motor sequence. This learning process is characterized by slow, incremental gains of motor performance. The present fMRI study was developed to better delineate the areas supporting these temporal dynamics of learning.

Salience maps in parietal cortex: imaging and computational modeling.

Models of spatial attention are often based on the concept of a salience map. In computational cognitive neuroscience, such maps are implemented as a collection of nodes with self-excitation and lateral inhibition between all nodes (competitive interaction map). Here, we test some critical predictions of this idea.

Number processing pathways in human parietal cortex.

Numerous studies have identified the intraparietal sulcus (IPS) as an area critically involved in numerical processing. IPS neurons in macaques are tuned to a preferred numerosity, hence neurally coding numerosity in a number-selective way. Neuroimaging studies in humans have demonstrated number-selective processing in the anterior parts of the IPS.

Priming reveals differential coding of symbolic and non-symbolic quantities.

Number processing is characterized by the distance and the size effect, but symbolic numbers exhibit smaller effects than non-symbolic numerosities. The difference between symbolic and non-symbolic processing can either be explained by a different kind of underlying representation or by parametric differences within the same type of underlying representation. We performed a primed naming study to investigate this issue.

Distinct binding properties of the AT(1) receptor antagonist [(3)H]candesartan to intact cells and membrane preparations.

[(3)H]-2-Ethoxy-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1H-benzimidazoline-7-carboxylic acid ([(3)H]candesartan), a non-peptide angiotensin II type 1 receptor (AT(1) receptor) antagonist bound with high affinity and specificity to intact adherent human AT(1) receptor transfected Chinese hamster ovary cells. The binding characteristics were preserved when cells were suspended, but the dissociation was 3-4-fold faster and the affinity 2-fold lower, while examining [(3)H]candesartan binding to cell membranes. These data suggested the role of the intracellular organisation of living CHO-hAT(1) cells in antagonist-AT(1) receptor interactions.