Publications by authors named "Chantal Kress"
Disruption of the mitotic kinesin Eg5 gene (Knsl1) results in early embryonic lethality.
Biochem Biophys Res Commun
August 2008
Eg5, a member of the widely conserved kinesin-5 family, is a plus-end-directed motor involved in separation of centrosomes, and in bipolar spindle formation and maintenance during mitosis in vertebrates. To investigate the requirement for Eg5 in mammalian development, we have generated Eg5 deficient mice by gene targeting. Heterozygous mice are healthy, fertile, and show no detectable phenotype, whereas Eg5(-/-) embryos die during early embryogenesis, prior to the implantation stage.
View Article and Find Full Text PDFCUG-BP1/CELF1 is a multifunctional RNA-binding protein involved in the regulation of alternative splicing and translation. To elucidate its role in mammalian development, we produced mice in which the Cugbp1 gene was inactivated by homologous recombination. These Cugbp1(-/-) mice were viable, although a significant portion of them did not survive after the first few days of life.
View Article and Find Full Text PDFArticle Synopsis
- Researchers created a mouse strain with a modified Fas ligand (FasL) gene to study its in vivo function, using loxP sequences to control gene deletion.
- Mice with two copies (homozygous) of the floxed FasL gene showed no apparent issues, but removing the FasL gene through mating with Cre recombinase mice caused severe health problems.
- The FasL(-/-) mice had extreme spleen enlargement, swollen lymph nodes, and autoimmune symptoms, leading to over 50% of them dying by four months old, contrasting with milder symptoms in other related mice strains.