GATA3 is a master regulator of the transcriptional response to low-dose ionizing radiation in human keratinocytes.

Background: The general population is constantly exposed to low levels of radiation through natural, occupational or medical irradiation. Even if the biological effects of low-level radiation have been intensely debated and investigated, the molecular mechanisms underlying the cellular response to low doses remain largely unknown.

Results: The present study investigated the role of GATA3 protein in the control of the cellular and molecular response of human keratinocytes exposed to a 1 cGy dose of X-rays.

Simulation of four-dimensional CT images from deformable registration between inhale and exhale breath-hold CT scans.

Purpose: We propose to simulate an artificial four-dimensional (4-D) CT image of the thorax during breathing. It is performed by deformable registration of two CT scans acquired at inhale and exhale breath-hold.

Materials And Methods: Breath-hold images were acquired with the ABC (Active Breathing Coordinator) system.

Respiratory signal extraction for 4D CT imaging of the thorax from cone-beam CT projections.

Current methods of four-dimensional (4D) CT imaging of the thorax synchronise the acquisition with a respiratory signal to restrospectively sort acquired data. The quality of the 4D images relies on an accurate description of the position of the thorax in the respiratory cycle by the respiratory signal. Most of the methods used an external device for acquiring the respiratory signal.

Early variations of circulating interleukin-6 and interleukin-10 levels during thoracic radiotherapy are predictive for radiation pneumonitis.

Purpose: To investigate variations of circulating serum levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha), and interleukin-10 (IL-10) during three-dimensional conformal radiation therapy (3D-CRT) in patients with non-small-cell lung cancer and correlate these variations with the occurrence of radiation pneumonitis.

Patients And Methods: Ninety-six patients receiving 3D-CRT for stage I to III disease were evaluated prospectively. Circulating cytokine levels were determined before, every 2 weeks during, and at the end of treatment.

Nonrigid registration method to assess reproducibility of breath-holding with ABC in lung cancer.

Purpose: To study the interfraction reproducibility of breath-holding using active breath control (ABC), and to develop computerized tools to evaluate three-dimensional (3D) intrathoracic motion in each patient.

Methods And Materials: Since June 2002, 11 patients with non-small-cell lung cancer enrolled in a Phase II trial have undergone four CT scans: one during free-breathing (reference) and three using ABC. Patients left the room between breath-hold scans.

A prospective study on radiation pneumonitis following conformal radiation therapy in non-small-cell lung cancer: clinical and dosimetric factors analysis.

Background And Purpose: Clinical and dosimetric prognostic factors for radiation pneumonitis (RP) have been reported after three-dimensional conformal radiotherapy (3D-CRT) in patients with non-small cell lung cancer (NSCLC).

Patients And Methods: Ninety-six patients who received 3D-CRT for stage IA to IIIB NSCLC were evaluated prospectively. Surgery was performed before radiation in 51% of the patients (n = 49).

Patient setup error measurement using 3D intensity-based image registration techniques.

Purpose: Conformal radiotherapy requires accurate patient positioning with reference to the initial three-dimensional (3D) CT image. Patient setup is controlled by comparison with portal images acquired immediately before patient treatment. Several automatic methods have been proposed, generally based on segmentation procedures.

Three-dimensional conformal radiotherapy for paranasal sinus carcinoma: clinical results for 25 patients.

Purpose: To assess local control, survival, and clinical and dosimetric prognostic factors in 25 patients with locally advanced maxillary or ethmoid sinus carcinoma treated by three-dimensional conformal radiotherapy (RT).

Materials And Methods: Surgery was performed in 22 patients and was macroscopically complete in 16. Seven patients received chemotherapy (concomitant with RT in four).