Injecting postpartal gilts or sows with a supraphysiological dose of oxytocin: effects on sow and piglet performances.

The goal of this project was to determine the effects of a supraphysiological dose of oxytocin given to gilts or multiparous sows 8 to 12 h after the end of farrowing on the performance of their progeny. Sows from three parity groups (1 = parity 1; 2 = parities 2, 3, and 4; 3 = parities 5 to 14) received no injection (CTL, controls;  = 17, 27, and 23 for parity groups 1, 2, and 3, respectively) or one intramuscular injection of 75 IU of oxytocin (OXY,  = 17, 24, and 26 for parity groups 1, 2, and 3, respectively) 8 to 12 h after birth of the last piglet. Colostrum samples were obtained 8 h after oxytocin injection in 18 sows from parity group 2 (CTL,  = 10; OXY,  = 8).

Parity affects mammary development in late-pregnant swine.

The goal of this project was to determine whether various measures of mammary development differed between gilts and multiparous sows at the end of gestation. During gestation, Yorkshire × Landrace gilts ( = 19) and sows (second and third gestations,  = 17) were fed one daily meal of a conventional corn-based diet, where the amount fed was based on body weight (BW) and backfat thickness (BF) at mating. On day 110 ± 1 of gestation, a jugular blood sample was obtained from all gilts and sows to measure insulin-like growth factor-1 (IGF-1), glucose, free fatty acids, and urea.

Optimal protein concentration in diets for sows during the transition period.

The aim of the present study was to determine the optimal concentration of dietary protein required in transition diets for multiparous sows that enhance the farrowing process, colostrum production, and subsequent lactation performance. Forty-eight multiparous sows were allotted to one of six dietary treatments according to body weight (290 ± 3 kg) and parity (3.8 ± 0.

Dietary supplementation with lysine (protein) in late pregnancy does not enhance mammary development in multiparous sows.

This project was conducted to determine if providing standardized ileal digestible (SID) Lys at 40% above estimated requirements (NRC, 2012), with the concomitant increased protein intake, from days 90 to 110 of gestation stimulates mammary development in multiparous sows. From day 90 of gestation, Yorkshire × Landrace multiparous sows (parities 2 and 3) were fed 2.6 kg/d of either a conventional diet (CTL, control, n = 17) providing 14.

Effects of sustained hyperprolactinemia in late gestation on the mammary parenchymal tissue transcriptome of gilts.

Background: Gilts experiencing sustained hyperprolactinemia from d 90 to 109 of gestation showed an early onset of lactogenesis coupled with premature mammary involution. To better understand the molecular mechanisms underlying the premature mammary involution observed in these gilts, a transcriptomic analysis was undertaken. Therefore, this study aimed to explore the effect of hyperprolactinemia on the global transcriptome in the mammary tissue of late gestating gilts and identify the molecular pathways involved in triggering premature mammary involution.

The effect of moderate energy and protein restriction during gilt development on changes in body weight and backfat depth and subsequent lactation performance.

Eighty-eight gilts [initial body weight (BW) 49.8 ± 0.8 kg] were recruited to determine the effects of moderate energy and protein restriction during the development period on changes in BW and backfat depth (BF) and subsequent lactation performance.

Review: Physiology and nutrition of late gestating and transition sows.

The physiology during late gestation and the transition period to lactation changes dramatically in the sow, especially during the latter period. Understanding the physiological processes and how they change dynamically as the sow approaches farrowing, nest building, giving birth to piglets, and producing colostrum is important because these processes greatly affect sow productivity. Glucose originating from assimilated starch accounts for the majority of dietary energy, and around farrowing, various organs and peripheral tissues compete for plasma glucose, which may become depleted.

Dietary supplementation with lysine (protein) stimulates mammary development in late pregnant gilts.

The goal of this project was to determine if standardized ileal digestible (SID) lysine provided at 40% above estimated requirements, with the concomitant increase in protein intake, from days 90 to 110 of gestation would stimulate mammary development in gilts. From day 90 of gestation, Yorkshire × Landrace gilts were fed 2.65 kg of either a conventional diet (CTL, control, n = 19) providing 18.

Providing domperidone throughout lactation enhances sow lactation performance.

The goal of this project was to determine the effects of domperidone given throughout lactation on hormonal and metabolic status, lactational performance, and gene expression in mammary epithelial cells of sows. Second parity sows were divided in two treatment groups: 1) daily intramuscular injections with canola oil (Control, CTL, n = 24), or 2) daily intramuscular injections with 0.5 mg/kg body weight (BW) of domperidone (DOMP, n = 23).

Impact of arginine supplementation on serum prolactin and mRNA abundance of amino acid transporter genes in mammary tissue of lactating sows.

This study was conducted to test the hypothesis that supplemental dietary Arg to late-pregnant and lactating sows increases serum prolactin concentrations and mRNA abundance of SLC7A1, SLC7A2, and SLC6A14 in mammary parenchymal tissue. From day 108 of gestation and until day 21 of lactation, sows were fed a diet either supplemented with 0.10 g of l-Arg/kg body weight (BW) per day (n = 10, ARG) or 0.

The combination of nutraceuticals and functional feeds as additives modulates gut microbiota and blood markers associated with immune response and health in weanling piglets.

This study aimed to evaluate the effects of a combination of feed additives with complementary functional properties on the intestinal microbiota, homocysteine, and vitamins E and B status as well as systemic immune response of weanling piglets. At weaning, 32 litters were assigned to one of the following dietary treatments (DT): 1) conventional diet (CTRL); 2) CTRL diet supplemented with antibiotics (ATB); 3) a cocktail of feed additives containing cranberry extract, encapsulated carvacrol, yeast-derived products, and extra vitamins A, D, E, and B complex (CKTL); or 4) CKTL diet with bovine colostrum in replacement of plasma proteins (CKTL + COL). Within each litter, the piglets with lowest and highest birth weights (LBW and HBW, respectively) and two piglets of medium birth weight (MBW) were identified.

Effects of supplementing processed straw during late gestation on sow physiology, lactation feed intake, and offspring body weight and carcass quality1.

This study investigated the effects of supplementing late gestation sow diets with processed or unprocessed oat or wheat straw on physiology, early lactation feed intake, and offspring performance. One hundred fifty gestating sows were randomly assigned to 1 of 5 dietary treatments (30 sows per diet) from day 86 of gestation until farrowing. Treatments, arranged as a 2 × 2 factorial plus a control, were a standard gestation diet (control) or control supplemented with 10% wheat or oat straw, processed or unprocessed.

Exogenous porcine somatotropin stimulates mammary development in late-pregnant gilts.

The goal of this project was to determine if increasing insulin-like growth factor-1 (IGF-1) concentrations in late pregnancy can stimulate mammogenesis in gilts. Yorkshire × Landrace gilts of a similar body weight (BW; 196.2 ± 6.

Body condition of late pregnant gilts affects the expression of selected adipokines and their receptors in mammary fat and backfat tissues.

The impact of body condition in late gestating gilts on gene expression of selected adipokines and their receptors in backfat and mammary fat tissues was studied. The presence of associations between mammary gland composition variables and the mRNA abundance of selected genes and serum concentrations of adiponectin and leptin was also investigated. A total of 45 gilts were selected at mating based on their backfat depth and were allocated to three groups: (1) low backfat (LBF; 12-15 mm; n = 14), (2) medium backfat (MBF; 17-19 mm; n = 15), and (3) high backfat (HBF; 22-26 mm; n = 16).

Nutritional impact on mammary development in pigs: a review.

Milk yield is a crucial component of a sow operation because it is a limiting factor for piglet growth rate. Stimulating mammary development is one avenue that could be used to improve sow milk production. A number of studies have shown that nutrition of gilts or sows during the periods of rapid mammary accretion occurring during prepuberty, gestation, and lactation can affect mammary development.

Impact of diet deprivation and subsequent overallowance during gestation on lactation performance of primiparous sows.

The impact of diet deprivation followed by overallowance during gestation on metabolic status of pregnant gilts and their lactation performance was determined. Gilts were fed a standard diet until day 27 of gestation and were subsequently reared under a control (; = 28) or an experimental (treatment, ; = 26) dietary regimen. The experimental regimen provided 70% (restriction diet, ) and 115% (overallowance diet, ) of the protein and NE contents provided by the CTL diet.

Distribution of isoflavones in samples of serum, liver and mammary glands of rats or pigs fed dietary isoflavones.

Background/aims: There has been great interest in the potential beneficial and adverse health effects of dietary isoflavones. Determination of tissue concentrations of isoflavone metabolites provides an insight into the potential bioactivity of dietary isoflavones. However, data on the distribution of isoflavones in animal models fed dietary isoflavones are limited.

Tissue-specific regulation of porcine prolactin receptor expression by estrogen, progesterone, and prolactin.

Prolactin (PRL) acts through its receptor (PRLR) via both endocrine and local paracrine/autocrine pathways to regulate biological processes including reproduction and lactation. We analyzed the tissue- and stage of gestation-specific regulation of PRL and PRLR expression in various tissues of pigs. Abundance of pPRLR-long form (LF) mRNA increased in the mammary gland and endometrium during gestation while in other tissues it remained constant.

Mammary arteriovenous differences of glucose, insulin, prolactin and IGF-I in lactating sows under different protein intake levels.

Mammary uptake of nutrients is dependent on their availability in the circulation but the role of hormones in that process is not known. Arteriovenous differences (AVD) of glucose and key hormones across the mammary glands were therefore determined in sows fed varying levels of protein. Sixteen lactating sows (four/dietary treatment) were fed a 7.

Dietary protein restriction during lactation in primiparous sows with different live weights at farrowing: I. Consequences on sow metabolic status and litter growth.

The hypothesis that the restriction of dietary protein during lactation has different impacts on sow metabolic status and milk production according to body weight was evaluated. From 5-months of age until farrowing, the gilts were fed to achieve body weights of 180 or 240 kg at farrowing. At this time, 38 sows were assigned to one of three groups: " 180 kg" sows not restricted in dietary protein during lactation (180CP); "180 kg" restricted in protein (180LP), or "240 kg" sows restricted in protein (240LP).

Hormones, IgG and lactose changes around parturition in plasma, and colostrum or saliva of multiparous sows.

Blood, colostrum and saliva samples were serially taken from 6 multiparous sows from day 109 of gestation until day 3 postpartum. Plasma was assayed for oestradiol-17beta (E2), progesterone (P4), prolactin (PRL), cortisol, immunoglobulin G (IgG) and lactose. Colostrum was assayed for E2, P4, IgG and lactose.