Interaction mechanism between low molecular weight chitosan nanofilm and functionalized surfaces in aqueous solutions.

Low-molecular-weight chitosan (LMW chitosan, <10 kDa) have a significant potential for biomedical applications (e.g., antimicrobial and gene/drug delivery) because of their higher water solubility at pH values ranging from 3.

Peptidomimetic Wet-Adhesive PEGtides with Synergistic and Multimodal Hydrogen Bonding.

The remarkable underwater adhesion of mussel foot proteins has long been an inspiration in the design of peptidomimetic materials. Although the synergistic wet adhesion of catechol and lysine has been recently highlighted, the critical role of the polymeric backbone has remained largely underexplored. Here, we present a peptidomimetic approach using poly(ethylene glycol) (PEG) as a platform to evaluate the synergistic compositional relation between the key amino acid residues (, DOPA and lysine), as well as the role of the polyether backbone in interfacial adhesive interactions.

Size compatibility and concentration dependent supramolecular host-guest interactions at interfaces.

The quantification of supramolecular host-guest interactions is important for finely modulating supramolecular systems. Previously, most host-guest interactions quantified using force spectroscopic techniques have been reported in force units. However, accurately evaluating the adhesion energies of host-guest pairs remains challenging.

Intermolecular interactions of chitosan: Degree of acetylation and molecular weight.

The degree of acetylation (DA), which determines as the molar proportion of N-acetyl-D-glucosamine units on chitosan, characterizes the physical, chemical, and biological properties of chitosan. Thus, DA can be a critical factor in the utilization of chitosan. Nevertheless, quantitative studies on the molecular interactions of chitosan as a function of DA are lacking.

Probing nanomechanical interaction at the interface between biological membrane and potentially toxic chemical.

Various xenobiotics interact with biological membranes, and precise evaluations of the molecular interactions between them are essential to foresee the toxicity and bioavailability of existing or newly synthesized molecules. In this study, surface forces apparatus (SFA) measurement and Langmuir trough based tensiometry are performed to reveal nanomechanical interaction mechanisms between potential toxicants and biological membranes for ex vivo toxicity evaluation. As a toxicant, polyhexamethylene guanidine (PHMG) was selected because PHMG containing humidifier disinfectant and Vodka caused lots of victims in both S.

Nanomechanics of Poly(catecholamine) Coatings in Aqueous Solutions.

Mussel-inspired self-polymerized catecholamine coatings have been widely utilized as a versatile coating strategy that can be applied to a variety of substrates. For the first time, nanomechanical measurements and an evaluation of the contribution of primary amine groups to poly(catecholamine) coatings have been conducted using a surface-forces apparatus. The adhesive strength between the poly(catecholamine) layers is 30-times higher than that of a poly(catechol) coating.

Mussel-Inspired Anchoring of Polymer Loops That Provide Superior Surface Lubrication and Antifouling Properties.

We describe robustly anchored triblock copolymers that adopt loop conformations on surfaces and endow them with unprecedented lubricating and antifouling properties. The triblocks have two end blocks with catechol-anchoring groups and a looping poly(ethylene oxide) (PEO) midblock. The loops mediate strong steric repulsion between two mica surfaces.

Contact time- and pH-dependent adhesion and cohesion of low molecular weight chitosan coated surfaces.

Low molecular weight chitosan (LMW chitosan, ∼5 kDa) potentially has many desirable biomedical applications such as anti-microbial, anti-tumor, and anti-diabetes. Unlike high molecular weight chitosan, LMW chitosan is easily dissolvable in aqueous solutions even at neutral and basic pH, but its dissolution mechanism is not well understood. Here, we measured adhesion and cohesion of molecularly thin LMW chitosan films in aqueous solutions in different buffer pHs (from 3.

Strong adhesion and cohesion of chitosan in aqueous solutions.

Chitosan, a load-bearing biomacromolecule found in the exoskeletons of crustaceans and insects, is a promising biopolymer for the replacement of synthetic plastic compounds. Here, surface interactions mediated by chitosan in aqueous solutions, including the effects of pH and contact time, were investigated using a surface forces apparatus (SFA). Chitosan films showed an adhesion to mica for all tested pH ranges (3.

Dopamine-Mediated Sclerotization of Regenerated Chitin in Ionic Liquid.

Chitin is a promising structural material for biomedical applications, due to its many advantageous properties and abundance in nature. However, its usage and development in the biomedical field have been stagnant, because of chitin's poor mechanical properties in wet conditions and the difficulties in transforming it into an applicable form. To overcome these challenges, we created a novel biomimetic chitin composite.