Development of a Cell-Based Assay for Identifying K3.1 Inhibitors Using Intestinal Epithelial Cell Lines.

Inhibition of the K3.1 potassium channel has therapeutic potential in a variety of human diseases, including inflammation-associated disorders and cancers. However, K3.

Discovery of a novel chalcone derivative inhibiting CFTR chloride channel via AMPK activation and its anti-diarrheal application.

Secretory diarrhea is one of the most common causes of death world-wide especially in children under 5 years old. Isoliquiritigenin (ISLQ), a plant-derived chalcone, has previously been shown to exert anti-secretory action in vitro and in vivo by inhibiting CFTR Cl channels. However, its CFTR inhibition potency is considerably low (IC > 10 μM) with unknown mechanism of action.