Publications by authors named "Changzun Jiang"

Background: Hypertrophic cardiomyopathy (HCM) with tachyarrhythmias has been extensively studied in recent years. The characteristics of primary bradycardia in HCM remain largely unknown.

Objective: This study aimed to comprehensively investigate the prevalence, clinical features, and prognosis of primary bradycardia in patients with HCM in a large cohort.

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Introduction: An adductor canal block (ACB) is widely accepted as a regional nerve block for pain management following total knee arthroplasty (TKA). However, no consensus exists concerning whether the analgesic effect is greater when joint surgeons perform intra-articular ACBs (IA-ACBs) or when anesthesiologists perform ultrasound-guided ACBs (UG-ACBs). We hypothesized that intra-articular ACBs (IA-ACBs) performed by joint surgeons and UG-ACBs performed by anesthesiologists based on peri-articular injections (PAI) would yield equivalent analgesic effects.

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Porous architecture of titanium implants offers significant advantages in promoting osseointegration and mitigating the "stress shielding" effect. However, challenges remain in enhancing vascularization and preventing infection, especially given the complexities of modifying the intricate surface structure of porous titanium (PT). This study introduces a novel surface modification technique of PT using anti-gravity perfusion electrophoretic deposition (EPD) technique to fabricate antibacterial coatings containing silver (Ag) and copper (Cu) co-doped mesoporous silica nanoparticles (Ag-Cu@MSN) and chitosan binder on the surface of PT.

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The bifunctional electrocatalysts for hydrogen and oxygen evolution reactions (HER and OER) are crucial pivot in water electrolysis territory. In this study, vertically Fe incorporated CoMoP (Fe-CoMoP) nanosheet honeycomb product with super-hydrophilic and aerophobic features was projected and generated through the straightforward hydrothermal technique and phosphatized process. The Fe-CoMoP catalyst exhibits more distinguished intrinsic activity, accessible active sites, effective charge transfer and weak adhesion of gas bubbles.

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Celosia argentea Linn. is a hyperaccumulator for the remediation of manganese (Mn)-contaminated soil owing to its rapid growth, high decontamination capacity, and strong stress resistance. However, little is known about the processes involved in long-distance transport of Mn in hyperaccumulators.

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Poultry molting is a natural phenomenon, and process that improves the physiological function of laying hens. In this study, artificial intervention was used to induced molting (IM) in aged hens and improve their egg- laying performance. Jejunal lipophagy and lipid metabolism data were analyzed to elucidate the regulatory mechanisms by which the intestine affects egg production performance, particularly through the lens of digestion and absorption processes.

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Aeromonas salmonicida belongs to the Aeromonas family, which could widely infect economic fish, causing diseases and huge economic losses. Recently, A. salmonicida was also detected in diseased Odontobutis potamophila.

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Background: Cardiac fibrosis, a critical factor in myocardial remodeling post-myocardial infarction (MI), can advance heart failure progression. Atractylenolide III (ATL-III), derived from Atractylodes lancea, has recognized antioxidant and anti-inflammatory effects; however, its influence on cardiac fibrosis remains unclear.

Methods: MI was induced in mice by permanent ligation of the left anterior descending (LAD) coronary artery, followed by 2 weeks of ATL-III or dimethyl sulfoxide (DMSO) treatment.

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As the global population ages, the incidence of age-related musculoskeletal diseases continues to increase, driven by numerous complex and poorly understood factors. WNT-1 inducible secreted protein 1 (WISP-1), a secreted matrix protein, plays a critical role in the growth and development of the musculoskeletal system, including chondrogenesis, osteogenesis, and myogenesis. Numerous in vivo and in vitro studies have demonstrated that WISP-1 is significantly upregulated in age-related musculoskeletal conditions, such as osteoarthritis, osteoporosis, and sarcopenia, suggesting its involvement in the pathogenesis of these diseases.

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Background: Despite the global public health threat posed by carbapenem-resistant Enterobacter spp., clinical and molecular epidemiological studies on international isolates remain scarce. Historically, the taxonomy of Enterobacter has been challenging, limiting our understanding of the clinical characteristics and outcomes of carbapenemase-producing Enterobacter spp.

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Aberrant energy and substance metabolic pathways of tumor cells critically support tumor cell proliferation by hijacking the resources from nonmalignant cells, thereby establishing a metabolite flow favorable to tumor progression. This metabolic adaptation of tumor cells further modulates the immune landscape, ultimately creating a tumor microenvironment characterized by drug resistance and immunosuppression. The synergistic regulation of energy and substance metabolic pathways might be a good antitumor therapeutic paradigm.

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Introduction: Use of oral anticoagulants (OACs) for stroke reduction in atrial fibrillation (AF) varies by race and geography within the United States. We seek to better understand the relationship between OAC underutilization, race, and US geography.

Methods: Patients with AF were selected from the US Centers for Medicare & Medicaid Services claims database from January 1, 2013, to December 31, 2016.

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The silicon anode suffers from significant volume expansion, low electrical conductivity, and poor long-term cycling performance, which collectively limit its potential to replace graphite as the anode material for lithium-ion batteries. In this article, a PAA-p(HEA-SBMA) binder was prepared by an in situ thermal cross-linking method, which combines strong mechanical properties and excellent reaction kinetics. The synergy of covalent bonding, dynamic hydrogen bonding, and ionic interactions in the binder structure provides excellent mechanical strength, which effectively dissipates stresses and "locks" the entire structure.

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Iron metabolism is a critical factor in tumorigenesis and development. Although TP53 mutations are prevalent in glioblastoma (GBM), the mechanisms by which TP53 regulates iron metabolism remain elusive. We reveal an imbalance iron homeostasis in GBM via TCGA database analysis.

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Purpose: To investigate whether the presence of kidney stones increases the risk of developing osteoporosis.

Methods: First, we performed an observational study on the basis of data from the National Health and Nutrition Examination Survey (NHANES; 2007-2020). Kidney stone patients were identified on the basis of their affirmative response to the question "Have you ever experienced kidney stones?" (KIQ026).

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Alcohol-induced health damage has become an increasing global public health concern. Anthocyanins exhibit essential biological activities, including antioxidation, anti-inflammation, and lipid reduction. This study investigates the rapid intervention effects and mechanisms of anthocyanin-rich blueberry extract in mitigating acute alcohol exposure in mice, aiming to uncover its novel nutritional roles.

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Members of the fungal genus Stagonosporopsis are important plant pathogens that can cause severe disease on a wide range of economically important plants and crops. Here, a novel victorivirus, tentatively named "Stagonosporopsis citrulli victorivirus 1" (SciVV1), was isolated from S. citrulli isolate HS2-8.

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Objectives: To develop and externally validate a fully automated diagnostic convolutional neural network (CNN) model for cirrhosis based on liver MRI and serum biomarkers.

Methods: This multicenter retrospective study included consecutive patients receiving pathological evaluation of liver fibrosis stage and contrast-enhanced liver MRI between March 2010 and January 2024. On the training dataset, an MRI-based CNN model was constructed for cirrhosis against pathology, and then a combined model was developed integrating the CNN model and serum biomarkers.

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Objective: To identify proliferative hepatocellular carcinoma (HCC) preoperatively using quantitative measurements combined with the updated standard 2021 LI-RADS universal lexicon-based qualitative features on multiphase dynamic CT (MDCT).

Methods: We retrospectively analyzed 273 patients (102 proliferative HCCs) who underwent preoperative MDCT with surgically confirmed HCC in two medical centers. Imaging features were evaluated according to the updated 2021 LI-RADS universal lexicon, and quantitative measurements were analyzed.

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Background: Herpes zoster (HZ), triggered by the reactivation of the varicella-zoster virus, manifests as a painful rash known as zoster-associated pain (ZAP), which can progress to postherpetic neuralgia (PHN). This study evaluates the efficacy and safety of ultrasound-guided thoracic paravertebral injections of platelet-rich plasma (PRP) in managing acute ZAP and preventing PHN.

Methods: This is a prospective, randomized, controlled, open-label, endpoint-blinded, single-center trial involving 128 participants suffering from zoster-associated pain.

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The mere token strategy, which adds a small reward (token) to an option to increase attractiveness, is widely used in the consumer field. However, we conducted six studies that seek to confirm the 'token undermining effect', where adding a small token to a sooner and smaller reward (SS) paired with a later and larger reward (LL) decreases the preference for the SS. The results showed that the effect persists across various choice sets, participant populations, reward amounts, delays, outcome properties and regardless of whether the scenarios are incentivized.

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Copper-catalyzed cycloaddition/coupling cascades utilizing azomethine imines and alkynes have been developed for the divergent synthesis of ()-alkenyl and alkynyl ,-bicyclic pyrazolidinones by varying the reaction conditions. The choice of inert or oxidative atmosphere plays a crucial role in determining the transformation pathways. These reactions have broad substrate scopes and mild conditions, making them potentially useful.

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