Superhydrophilicity and Electronic Modulation on Self-Supported Lignin-Derived Carbon Coupled with NiO@MoNi for Enhancing Urea Electrolysis.

Developing highly efficient biomass-derived carbon-based electrocatalysts remains challenging for urea electrolysis because most of these electrocatalysts show powder morphology, which can lead to Ostwald ripening during the reaction process, and its reaction mechanism should be further verified. Herein, self-supported lignin-derived carbon coupling NiO@MoNi heterojunction (NiO@MoNi/C) possesses superhydrophilic properties and electronic modulation, boosting the performance of urea electrolysis. Electrochemical results show that an indirect oxidation step for urea oxidation reaction (UOR) and Volmer-Heyrovsky mechanism for hydrogen evolution reaction (HER) occurs on the surface of NiO@MoNi/C.

The intrahepatic bacterial metataxonomic signature of patients with hepatocellular carcinoma.

Dysbiosis of the gut-liver axis increases the risk of bacterial and metabolite influx into the liver, which may contribute to the development of hepatocellular carcinoma (HCC). In this study, we compared the microbiomes in HCC tumors and adjacent tissues. We examined the HCC tumors and adjacent tissues from 19 patients diagnosed with HCC.

Interfacial Interaction between Zn and Surface Functional Groups Impacting Self-Assembly of ZnO on Cellulose Nanofibrils.

The mechanism underlying the interfacial interaction between ZnO and surface functional groups, which drives the self-assembly of ZnO nanoflowers on the cellulose nanofibril (CNF) surface, remains inadequately understood. Moreover, the ideal sites for the loading and growth of ZnO nanoflowers on the oxygen atoms (O) of various surface functional groups on the CNF surface are not well-defined. This work addressed these gaps by systematically regulating the size and surface charge density of CNF templates through minor surface modifications and adjustments in processing cycles by using an ultrafine grinder.

Electromagnetic porous lignocellulosic matrix composites: A green electromagnetic shielding material with high absorption efficient electromagnetic interference.

Electromagnetic interference (EMI) shielding materials play a vital role in human society, especially in light of the rapid development of electronic communication equipment. Therefore, it is urgent to develop green, high-efficiency EMI shielding materials. Wood, as a renewable raw material, possesses significant structural advantages in studying EMI materials due to its unique 3D pore structure.

A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.

CircRNAs participates in the development and occurrence of multiple tumor types. However, the specific effects and underlying mechanisms of circRNA in intrahepatic cholangiocarcinoma (ICC) progression and recurrence remain poorly understood. CircRNA sequencing was performed to screen circRNAs related to ICC recurrence after surgery using 53 ICC frozen tumor specimens.

Boosting 5-Hydroxymethylfurfural Electrooxidation by Porous Biochar via Loading Numerous Surface-Exposed Cobalt Phosphonates.

The electrooxidation of 5-hydroxymethylfurfural (HMF) into 2,5-furandicarboxylic acid (FDCA) demonstrated its unique superiority, not only in reducing overpotential and improving energy conversion efficiency for green hydrogen production but also in utilizing abundant biomass resources and producing high-value-added chemicals. However, designing highly efficient electrocatalysts for HMF electrooxidation (HMF-EOR) with low cost and high performance for large-scale production remained a huge challenge. Herein, we introduced an easy one-step activation process to produce P-doped porous biochar loaded with multiple crystal surfaces exposed to CoPO catalysts (CoPO@PC), which exhibited outstanding electrooxidation performance.

Synergy of metallic Co and oxygen vacancy sites in Co/Ce-MOF catalysts for efficiently promoting lignin derived phenols and macromolecular lignin hydrodeoxygenation.

The enhanced utilization of biomass-derived chemicals for the generation of high value aromatics through an advanced catalytic strategy has captured considerable attention within the realm of eco-friendly manufacturing. This work presented four innovative three-dimensional rod-shaped mesoporous Ce-based MOF materials, which were coupled with a H-donor solvent to facilitate vanillin hydrodeoxygenation and macromolecular lignin. Under the optimized conditions (30 mg CoCe@C catalyst, 2 MPa N pressure, 15 mL isopropanol, 190 °C, and 5 h), the CoCe@C catalyst achieved nearly complete conversion of vanillin and demonstrated 87.

Tumor-associated macrophage-induced circMRCKα encodes a peptide to promote glycolysis and progression in hepatocellular carcinoma.

The tumor-associated macrophages (TAMs) play multifaceted roles in the progression of hepatocellular carcinoma (HCC). However, the involvement of circular RNAs in the interplay between TAMs and HCC remains unclear. Based on Transwell co-culturing and circular RNA sequencing, this study revealed that TAMs enhanced tumor glycolysis and progression by upregulating circMRCKα in HCC cells.

The Effect of Sports Game Intervention on Children's Fundamental Motor Skills: A Systematic Review and Meta-Analysis.

The purpose of the present study was to carry out a systematic review and a meta-analysis determining the effects of sports game intervention on fundamental motor skills in children. This paper presented a systematic review from 2001 to 2020, including the databases of Web of Science, EBSCO, Science, PubMed and Springer. (1) Participants comprised 1701 children age 3-12 years; (2) sports game interventions were investigated; (3) only studies using a Test of Gross Motor Skills assessment were included; (4) RCT were chosen as the study design to assess the impact of sports game interventions on children's motor skills; (5) only culture-based sports game studies in the English and Chinese language were included.

A highly sensitive fluorescence probe for on-site detection of nerve agent mimic diethylchlorophosphonate DCP.

Nerve agents are the most toxic chemical warfare agents that pose severe threat to human health and public security. In this work, we developed a novel fluorescent probe NZNN based on naphthylimide and -phenylenediamine to detect nerve agent mimic diethylchlorophosphonate (DCP). DCP underwent a specific nucleophilic reaction with the -phenylenediamine group of NZNN to produce a significant fluorescence turn-on response with high selectivity, exceptional linearity, bright fluorescence, rapid response (<6 s) and a low detection limit (30.

Design of Single-Atom Catalysts for E lectrocatalytic Nitrogen Fixation.

The Electrochemical nitrogen reduction reaction (ENRR) can be used to solve environmental problems as well as energy shortage. However, ENRR still faces the problems of low NH yield and low selectivity. The NH yield and selectivity in ENRR are affected by multiple factors such as electrolytic cells, electrolytes, and catalysts, etc.

macrophages promote hepatocellular carcinoma tumor stemness and progression through /β-catenin/ axis.

Liver cancer stem-like cells (LCSCs) are the main cause of heterogeneity and poor prognosis in hepatocellular carcinoma (HCC). In this study, we aimed to explore the origin of LCSCs and the role of the TOP2A/β-catenin/YAP1 axis in tumor stemness and progression. Using single-cell RNA-seq analysis, we identified LCSCs, which were mainly regulated by M2-like macrophages.

Deciphering photocatalytic degradation of methylene blue by surface-tailored nitrogen-doped carbon quantum dots derived from Kraft lignin.

Lignin in black liquor can be used to manufacture carbon nanomaterials on a large scale. However, the effect of nitrogen doping on the physicochemical properties and photocatalytic performance of carbon quantum dots (NCQDs) remains to be explored. In this study, NCQDs with different properties were prepared hydrothermally by using kraft lignin as the raw material and EDA as a nitrogen dopant.

Development of Engineered CAR T Cells Targeting Tumor-Associated Glycoforms of MUC1 for the Treatment of Intrahepatic Cholangiocarcinoma.

Intrahepatic cholangiocarcinoma (ICC) is a common malignancy arising from the liver with limited 5-year survival. Thus, there is an urgency to explore new treatment methods. Chimeric antigen receptor T (CAR T) cell therapy is a very promising cancer treatment.

Elevated STIL predicts poor prognosis in patients with hepatocellular carcinoma.

Overexpression of SCL/TAL1 interrupting locus (STIL) has been observed in various cancer types. However, the clinical significance of STIL in hepatocellular carcinoma (HCC) remains unknown. Cox regression and Kaplan-Meier survival analyses were performed to evaluate the prognostic value of STIL.

Self-Adhesive and Conductive Dual-Network Polyacrylamide Hydrogels Reinforced by Aminated Lignin, Dopamine, and Biomass Carbon Aerogel for Ultrasensitive Pressure Sensor.

Conductive hydrogels have attracted extensive interest owing to its potential in soft robotics, electronic skin, and human monitoring. However, insufficient mechanical properties, lower adhesivity, and unsatisfactory conductivity seriously hinder potential applications in this emerging field. Herein, a highly elastic conductive hydrogel with a combination of favorable mechanical properties, self-adhesiveness, and excellent electrical performance was achieved by the synergistic effect of aminated lignin (AL), polydopamine (PDA), polyacrylamide (PAM) chains, and biomass carbon aerogel (C-SPF).

Regulated by miR-22-5p Promotes Hepatocellular Carcinoma Invasion and Migration through the Hippo Pathway.

() are dysregulated in various types of cancer. However, how () contributes to hepatocellular carcinoma (HCC) progression remains elusive. Cohort analysis revealed that the increased expression of was associated with poor clinical outcomes and was significantly upregulated in HCC tissues and cell lines.

Analysis of the microscopic interactions between processed Polygonatum cyrtonema polysaccharides and water.

The dissolution and microscopic interactions of processed Polygonatum cyrtonema polysaccharides in water are extremely important because they strongly influence the process to extract these polysaccharides from water. In this paper, molecular dynamics simulation methods were used to analyse the influence of extraction temperature, concentration and molecular weight on the radial distribution function (RDF), mean square displacement (MSD), diffusion coefficient (D), radius of gyration (R), and microstructure of processed Polygonatum cyrtonema polysaccharides in water as well as the intrinsic viscosity (η), hydrogen bond characteristics and microscopic interactions in the solutions. The research results showed that the extraction temperature, concentration and molecular weight of the polysaccharides had important effects on the RDF, MSD, D, R, η, hydrogen bond characteristics and the microstructure of the polysaccharide molecules, but there were some major differences.

A facile and novel lignin isolation procedure - Methanolic hydrochloric acid treatment at ambient temperature.

Lignin is the most naturally abundant source of aromatics for phenolic chemicals, bioenergy sources, and functional materials. Recent works are devoted to the acid-catalyzed organosolv extraction for improving the lignin valorization. However, β-aryl ethers are mostly cleaved to form carbon-carbon bonds under the acidic condition.

Molten Salt-Assisted Synthesis of Co/N-Doped Carbon Hybrids for Aqueous-Phase Aerobic Oxidation of 5-Hydroxymethylfurfural to 2,5-Furandicarboxylic Acid.

A resource-efficient and facile method of synthesizing 2,5-furandicarboxylic acid (FDCA) from biomass-derived platform chemical 5-hydroxymethylfurfural (HMF) was explored using cobalt and nitrogen-doped carbon catalysts (Co/N-C). A molten salts-assisted method proved to be effective in improving the surface area of the catalysts as well as uniformity and dispersibility of the Co species. Detailed investigation of different combinations of precursors revealed that the formation of Co-N species was imperative for high FDCA selectivity, and the nitrogen-doped carbon matrix enhanced the catalytic activity by providing good electron mobility.

Single-cell RNA Sequencing Analysis Reveals New Immune Disorder Complexities in Hypersplenism.

Hypersplenism (HS) is a concomitant symptom of liver or blood disease. Not only does the treatment of HS face challenges, but the transcriptome of individual cells is also unknown. Here, the transcriptional profiles of 43,037 cells from four HS tissues and one control tissue were generated by the single-cell RNA sequencing and nine major cell types, including T-cells, B-cells, NK cells, hematopoietic stem cells, neutrophil cells, mast cells, endothelial cells, erythrocytes, and dendritic cells were identified.

Stretchable and conductive cellulose hydrogel electrolytes for flexible and foldable solid-state supercapacitors.

In this study, the anti-freezing conductive hydrogel electrolytes with outstanding mechanical properties were synthesized by a facile and feasible method. The mechanical and anti-freezing properties of the synthesized polyacrylamide/lithium lhloride/water soluble cellulose acetate (PAM/LiCl/WSCA) hydrogels are significantly enhanced with the addition of WSCA and LiCl. The tensile strength and toughness of the gels were gradually increased to 341 KPa and 1.

Ultrahigh compressibility and superior elasticity carbon framework derived from shaddock peel for high-performance pressure sensing.

Shaddock peel, a crop by-product mainly composed of cellulose, hemicellulose, lignin, and pectin, was developed as a flexible sensitive material for detecting environmental external pressure. Firstly, a natural carbon framework (C-SPF) with high conductivity was prepared using hydrothermal treatment followed by carbonization. Then, the PDMS elastomer was coated on the C-SPF instead of dense filling to convert the brittle C-SPF into elastic porous materials (M-SPF).

Prefoldin and prefoldin-like complex subunits as predictive biomarkers for hepatocellular carcinoma immunotherapy.

Background: Prefoldin complex subunits (PFDNs) and prefoldin-like complex subunits (PFDLNs) collaborate in protein folding, modulate endoplasmic reticulum stress. The association between PFDN/PFDLN and the immune microenvironment of HCC remains unclear. We investigated the biological significance of PFDNs and PFDLNs in HCC using bioinformatics.

Design of a Superhydrophobic Strain Sensor with a Multilayer Structure for Human Motion Monitoring.

A flexible strain sensor is of significant importance in wearable electronics since it can help monitor the physical signals from the human body. Among various strain sensors, the polyurethane (PU)-based ones have received widespread attention owing to their excellent toughness, large working range, and nice gas permeability. However, the hydrophobicity of these sensors is not good enough, which may affect their use life and sensitivity.