Based on UPLC-Q-TOF/MS and Network Pharmacology to Explore the Mechanism of Qingre Lishi Decoction in the Treatment of Psoriasis.

Background: Psoriasis is an immune-mediated chronic inflammatory disease. Qingre Lishi Decoction (QRLSD) has achieved great clinical effect in the treatment of psoriasis. However, the potential bioactive components and the mechanisms are yet unclear.

Ozonated Hydrotherapy Combined with LED Yellow Light Irradiation and Oral Minocycline Treatment for Mild to Moderate Papulopustular Rosacea: A Comparative Retrospective Study.

Objective And Design: The treatment of recurrent rosacea has always been a problem. Oral minocycline has been widely used in the treatment of rosacea. However, the efficacy and safety of ozonated hydrotherapy combined with LED yellow light irradiation and oral minocycline for mild to moderate papulopustular rosacea (PPR) has not been thoroughly studied.

Fire needle pretreatment with 5-aminolevulinic acid photodynamic therapy combined with low-dose isotretinoin in the treatment of severe refractory nodulocystic acne.

Background: Nodulocystic acne is a severe form of acne, which is commonly treated with oral isotretinoin, hormones, or antibiotics. However, drug therapy often has some side effects and poor compliance. Fire needle combined with 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is a simple, effective, short-term treatment with few adverse reactions, which is expected to be an effective physiotherapy for nodulocystic acne.

Dermatology Consultation in the Geriatrics Department of a Tertiary Hospital in China: A Retrospective Study of 178 Patients.

Objective: Dermatological consultation plays an important role in diagnosing and treating skin diseases in the Department of Geriatrics. The objective of this study is to provide an analysis of the factors leading geriatric inpatients to seek dermatological consultation, aiming to facilitate accurate diagnosis and effective treatment of skin diseases by healthcare professionals specializing in geriatrics and dermatology.

Methods: The electronic health records of hospitalized patients in the Department of Geriatrics who applied for dermatological consultation at the Second Hospital of Shandong University from June 1, 2022, to June 1, 2023, were retrieved.

Ternary Blends from Biological Poly(3-hydroxybutyrate--3-hydroxyhexanoate), Poly(propylene carbonate) and Poly(vinyl acetate) with Balanced Properties.

Poly(3-hydroxybutyrate--3-hydroxyhexanoate) (PHBH) has gained significant attention because of its biodegradability and sustainability. However, its expanded application in some fields is limited by the brittleness and low melt viscoelasticity. In this work, poly(vinyl acetate) (PVAc) was introduced into PHBH/poly(propylene carbonate) (PPC) blends via melt compounding with the aim of obtaining a good balance of properties.

Qingre Lishi Decoction ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice by regulating the Treg-DC-Th17 axis and inhibiting MAPK-mediated DC maturation.

Ethnopharmacological Relevance: Psoriasis, an immune system disorder, is a chronic relapsing disease that cannot be cured. Chinese herbal medicine is gradually considered a promising alternative treatment for psoriasis due to its multiple effects, ability to target multiple pathways and lower toxicity. Qingre Lishi Decoction (QRLSD) is effective in clinical treatment.

The combination treatment of ozone water, superficial shaving, and photodynamic therapy in recalcitrant plantar warts: A successful case.

In this work, we report the treatment of a patient with recalcitrant plantar warts with aminolevulinate photodynamic therapy (ALA-PDT), pretreatment with ozone water, and superficial shaving. Following a single treatment session, the lesions completely disappeared after three weeks and did not reappear during the two-year follow-up. Photodynamic therapy has been reported to be successful for plantar warts with a low recurrence rate, while ozone water is an emerging treatment for infectious skin diseases, which can modulate immunity without obvious side effects.

A Rigid and Planar Aza-Based Ternary Anhydride for the Preparation of Cross-Linked Polyimide Membrane Displaying High CO/CH Separation Performance.

In this study, based on the preparation of hexaazatriphenylene-ternary-anhydride (HAT-T), polyimide membranes were prepared by reaction of 4,4'-(hexafluoroisopropylidene)diphthalic anhydride (6FDA), 4,4'-diaminodiphenyl sulfide (SDA), 2,2'-bis (trifluoromethyl)diaminobiphenyl (TFDB) and 5-amino-2-(4-aminophenyl) benzimidazole (PABZ). Polyimide films with a hexazobenzo structure have good film-forming properties, high molecular weight ( = 0.79-11.

Ternary blends from biological poly(3-hydroxybutyrate-co-4-hydroxyvalerate), poly(L-lactic acid), and poly(vinyl acetate) with balanced properties.

Herein, poly(3-hydroxybutyrate-co-4-hydroxyvalerate) (P34HB), poly (L-lactic acid) (PLA), and poly(vinyl acetate) (PVAc) were initially melt compounded to prepare a ternary blend with balanced properties. Further, the miscibility, phase morphology, thermal and crystallization behaviors, and rheological and mechanical properties of the blends were studied. The dynamic mechanical analysis (DMA) results indicated that P34HB and PLA were partially miscible; however, PVAc showed full miscibility with PLA and P34HB.

Effect of loadings of nanocellulose on the significantly improved crystallization and mechanical properties of biodegradable poly(ε-caprolactone).

Biodegradable poly(ε-caprolactone) (PCL)/nanocellulose (NC) nanocomposites were prepared using solvent-free melt processing techniques with various NC contents. Both the nonisothermal and isothermal melt crystallization processes of PCL/NC nanocomposites were significantly accelerated by adding NC. The nonisothermal melt crystallization peak temperature obviously increased from 18.

Morphological, thermal, rheological and mechanical properties of poly (butylene carbonate) reinforced by stereocomplex polylactide.

Fully biodegradable blends of poly (butylene carbonate) (PBC) and a bioresource-based stereocomplex polylactide (sc-PLA) were prepared by melt compounding at a temperature far below the melting point (T) of sc-PLA, and above the T of PBC, poly (l-lactide) (PLLA) and poly(d-lactide) (PDLA). sc-PLA was uniformly dispersed in the PBC matrix as spherical particles. Interestingly, the size of the dispersed sc-PLA particles did not increase significantly with increasing amounts of PLLA and PDLA.

Enhancement of the properties of biosourced poly(3-hydroxybutyrate-co-4-hydroxybutyrate) by the incorporation of natural orotic acid.

The aim of this study is to use natural orotic acid (OA) as a sustainable, environmentally friendly additive to improve the crystallization, rheological, thermal, mechanical, and biodegradation properties of bacterially synthesized poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB). OA was found to be an efficient nucleating agent for P34HB, and dramatically enhanced both non-isothermal and isothermal crystallization rates. The incorporation of OA increased nucleation density and decreased spherulite size, but had little effect on the crystalline structure.

Uniaxial stretching and properties of fully biodegradable poly(lactic acid)/poly(3-hydroxybutyrate-co-4-hydroxybutyrate) blends.

In this work, fully biodegradable poly (lactic acid) (PLA)/poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)) blends of various compositions were uniaxially stretched at different stretch ratios above the glass transition temperature (T) of PLA. These stretched blends exhibited a closed microvoid structure, as evaluated by scanning electron microscopy. Differential scanning calorimetry and wide-angle X-ray diffraction analyses verified that stretching-induced crystallization in the α-form could be achieved in the PLA matrix.

LY2109761 reduces TGF-β1-induced collagen production and contraction in hypertrophic scar fibroblasts.

Hypertrophic scars (HS) are fibro-hyperproliferative dermal lesions with effusive continuous accumulation of extracellular matrix components, particularly collagen. They usually occur after dermal injury in genetically susceptible individuals and cause both physical and psychological distress for the affected individuals. Transforming growth factor-β1 (TGF-β1) is known to mediate wound healing process by regulating cell differentiation, collagen production and extracellular matrix degradation.

High-performance biodegradable polylactide composites fabricated using a novel plasticizer and functionalized eggshell powder.

A novel polyester poly(diethylene glycol succinate) (PDEGS) was synthesized and evaluated as a plasticizer for polylactide (PLA) in this study. Meanwhile, an effective sustainable filler, functionalized eggshell powder (FES) with a surface layer of calcium phenyphosphonate was also prepared. Then, PLA biocomposites were prepared from FES and PDEGS using a facile melt blending process.

Polycaprolactone nanocomposite reinforced by bioresource starch-based nanoparticles.

Biodegradable polymer nanocomposites with bioresource starch-based nanoparticles (SNPs) as reinforcing fillers for polycaprolactone (PCL) were prepared by melt blending. Scanning electron microscopy observation revealed that SNPs as spherical particles were evenly dispersed in the PCL matrix without any aggregation even with the content of SNPs increasing to 10wt% in the nanocomposite. Consequently, the rheological performances of PCL have been improved efficaciously after incorporation with SNPs as well as mechanical properties, especially with a percolation network structure of SNPs in the PCL matrix formed.

The physical properties of poly(l-lactide) and functionalized eggshell powder composites.

Aiming at improved crystallization performance and simultaneously enhanced solid-state properties of poly(l-lactide) such as mechanical properties and enzymatic hydrolysis. A novel functionalized eggshell powder decorated with calcium phenylphosphonic acid (NES) was synthesized via the chemical reaction between phenylphosphonic acid and calcium ion on the surface of eggshell powder to form effective nucleating surface for poly(l-lactide). The resultant NES was incorporated into PLLA matrix to form fully biodegradable composites by melt blending, which exhibited superior crystallization, mechanical properties, and enzymatic hydrolysis.