Molecular-level insights into dissolved organic matter and its variations of the full-scale processes in a typical petrochemical wastewater treatment plant.

Petrochemical wastewater (PCWW) treatment poses challenges due to its unique and complex dissolved organic matter (DOM) composition, originating from various industrial processes. Despite the addition of advanced treatment units in PCWW treatment plants to meet discharge standards, the mechanisms of molecular-level sights into DOM reactivity of the upgraded full-scale processes including multiple biological treatments and advanced treatment remain unclear. Herein, we employ water quality indexes, spectra, molecular weight (MW) distribution, and Fourier transform ion cyclotron resonance mass spectrometry to systematically characterize DOM in a typical PCWW treatment plant including influent, micro-oxygen hydrolysis acidification (MOHA), anaerobic/oxic (AO), and micro-flocculation sand filtration-catalytic ozonation (MFSF-CO).

Advancements of the Fluidized Bed Fenton (FBF) Technology for wastewater treatment: Mechanism, mass and heat transfer.

Fluidized Bed Fenton (FBF) technology, a fusion of the Fenton method and fluidized bed reactor, has emerged as a superior alternative to conventional Fenton technology for treating organic industrial wastewater. This innovative approach has garnered significant attention from researchers in recent years. While earlier studies primarily focused on pollutant degradation in simulated wastewater and catalyst development, there has been a growing interest in examining the alterations in mass or heat transfer performance attributed to fluidized beds.

Microbial synthesis of antimony sulfide to prepare catechol and hydroquinone electrochemical sensor by pyrolysis and carbonization.

The application of antimony sulfide sensors, characterized by their exceptional stability and selectivity, is of emerging interest in detection research, and the integration of graphitized carbon materials is expected to further enhance their electrochemical performance. This study represents a pioneering effort in the synthesis of carbon-doped antimony sulfide materials through the pyrolysis of the mixture of microorganisms and their synthetic antimony sulfide. The prepared materials are subsequently applied to electrochemical sensors for monitoring the highly toxic compounds catechol (CC) and hydroquinone (HQ) in the environment.

Towards zero excess sludge discharge with built-in ozonation for wastewater biological treatment.

In this study, a biological treatment process, which used a built-in ozonation bypass to achieve sludge reduction, was built to treat the industrial antifreeze production wastewater (mainly composed of ethylene glycol). The results indicated there is a positive correlation between ozone dosage and sludge reduction. At the laboratory level, the MLSS in the system can be stably controlled at around 3400 mg MLSS L under the dosage of 0.

Dual blockade of EGFR and PI3K signaling pathways offers a therapeutic strategy for glioblastoma.

Background: Glioblastoma multiforme (GBM) is a devastating disease that lacks effective drugs for targeted therapy. Previously, we found that the third-generation epidermal growth factor receptor (EGFR) inhibitor AZD-9291 persistently blocked the activation of the ERK pathway but had no inhibitory effect on the phosphoinositide 3-kinase (PI3K)/Akt pathway. Given that the PI3K inhibitor GDC-0084 is being evaluated in phase I/II clinical trials of GBM treatment, we hypothesized that combined inhibition of the EGFR/ERK and PI3K/Akt pathways may have a synergistic effect in the treatment of GBM.

Noncoding RNAs regulating ferroptosis in cardiovascular diseases: novel roles and therapeutic strategies.

The morbidity and mortality rates of cardiovascular diseases (CVDs) are increasing; thus, they impose substantial health and economic burdens worldwide, and effective interventions are needed for immediate resolution of this issue. Recent studies have suggested that noncoding RNAs (ncRNAs) play critical roles in the occurrence and development of CVDs and are potential therapeutic targets and novel biomarkers for these diseases. Newly discovered modes of cell death, including necroptosis, pyroptosis, apoptosis, autophagy-dependent cell death and ferroptosis, also play key roles in CVD progression.

Aluminum-based ozone catalysts prepared by mixing method: Characteristics, performance and carbon emissions.

Green and low carbon is an essential direction for the development of water treatment technology. Ozone catalysts prepared by the mixing method have advantages in terms of energy consumption and CO emissions, but are considered to be insufficient in catalytic efficiency and stability. In this paper, an Mn-Cu-Ce/AlO (MCCA) catalyst was prepared by optimizing the preparation conditions of the mixing method and the types and ratios of active components.

Upgrade of the biggest catalytic ozonation wastewater treatment plant in China: From pollution control to carbon reduction.

Catalytic ozonation is a widely used effective technology in advanced treatment for the removal of refractory organics from wastewater. However, it is also a highly energy-consuming technology, usually accounting for 30%∼40% of the total electricity consumption of a wastewater treatment plant (WWTP). The O consumption per unit of COD removed (g-O/g-COD) is usually higher than 1.

The response of nitrifying activated sludge to chlorophenols: Insights from metabolism and redox homeostasis.

The specialized wastewater treatment plants for the chemical industry are rapidly developed in China and many other countries. But there is a common bottleneck in that the toxic pollutants in chemical wastewater often cause shock impacts on biological nitrogen removal systems, which directly affects the stability and cost of operation. As the research on nitrification inhibition characteristics is not sufficient till now, there is a great lack of theoretical guidance on the control of the inhibition.

Preclinical evaluation of Mito-LND, a targeting mitochondrial metabolism inhibitor, for glioblastoma treatment.

Background: Glioblastoma (GBM) is a brain tumor with the highest level of malignancy and the worst prognosis in the central nervous system. Mitochondrial metabolism plays a vital role in the occurrence and development of cancer, which provides critical substances to support tumor anabolism. Mito-LND is a novel small-molecule inhibitor that can selectively inhibit the energy metabolism of tumor cells.

The destiny of microplastics in one typical petrochemical wastewater treatment plant.

Microplastic (MP) is a type of emerging contaminant that is verified to be threatening to some organisms. Controlling MP emission from the source is preferred for its refractory characteristic. The petrochemical industry is a possible contributor, responsible for the most plastic production, and wastewater is the most possible sink of MP.

Illustration on phenotypic and genotypic characteristics of typical multi-antibiotic resistant bacteria in aquatic environments through complete genomes and comparative genomics.

Antibiotic-resistant bacteria, especially multi-antibiotic-resistant bacteria (MARBs), greatly threaten environmental safety and human health. However, studies on the phenotypic resistance and complete genotypic characterization of MARB in aquatic environments are lacking. In this study, a multi-resistant superbug (TR3) was screened by the selective pressure of multi-antibiotics from the activated sludge of the aeration tanks of urban wastewater treatment plants (WWTPs) in 5 different regions of China.

UBA1 inhibition contributes radiosensitization of glioblastoma cells blocking DNA damage repair.

Glioblastoma multiforme (GBM) is a brain tumor with high mortality and recurrence rate. Radiotherapy and chemotherapy after surgery are the main treatment options available for GBM. However, patients with glioblastoma have a grave prognosis.

Is the petrochemical industry an overlooked critical source of environmental microplastics?

Microplastics (MPs) are ubiquitous in the environment and have been verified to be harmful to organisms. The petrochemical industry is a possible contributor, for it is the primary plastic producer but is not focused on. In this background, MPs in the influent, effluent, activated sludge, and expatriate sludge of a typical petrochemical wastewater treatment plant (PWWTP) were identified by the laser infrared imaging spectrometer (LDIR).

A tailored and rapid approach for ozonation catalyst design.

Catalytic ozonation is widely employed in advanced wastewater treatment owing to its high mineralization of refractory organics. The key to high mineralization is the compatibility between catalyst formulation and wastewater quality. Machine learning can greatly improve experimental efficiency, while fluorescence data can provide additional wastewater quality information on the composition and concentration of organics, which is conducive to optimizing catalyst formulation.

Noncoding RNAs and Cardiac Fibrosis.

Myocardial fibrosis is a common pathological feature of various terminal cardiovascular diseases. Progressive fibrosis is the pathological basis for the development and progression of many cardiac arrhythmias and heart failure. There are no effective reversal drugs for myocardial fibrosis due to the lack of understanding of the molecular mechanisms.

Microbial population properties in the hierarchically structured aerobic granular sludge: Phenotype and genotype.

Aerobic granular sludge (AGS) is a layered microbial aggregate formed by the ordered self-assembly of different microbial populations. In this study, the outer layer (OL), middle layer (ML), and the inner layer (IL) of matured AGS were obtained by circular cutting. The adhesion of microorganisms in IL was significantly higher than that in OL and ML during the famine period, while the adhesion of microorganisms in ML and OL was significantly higher than that in IL during the feast period, confirming that the formation of AGS started in the famine period, and the feast period promoted the increase of particle size.

Development, dilemma and potential strategies for the application of nanocatalysts in wastewater catalytic ozonation: A review.

With the continuous development of nanomaterials in recent years, the application of nanocatalysts in catalytic ozone oxidation has attracted more and more researchers' attention due to their excellent catalytic properties. In this review, we systematically summarized the current research status of nanocatalysts mainly involving material categories, mechanisms and catalytic efficiency. Based on summary and analysis, we found most of the reported nanocatalysts were in the stage of laboratory research, which was caused by the nanocatalysts defects such as easy aggregation, difficult separation, and easy leakage.

Formation, application, and storage-reactivation of aerobic granular sludge: A review.

It was an important discovery in wastewater treatment that the microorganisms in the traditional activated sludge can form aerobic granular sludge (AGS) by self-aggregation under appropriate water quality and operation conditions. With a typical three-dimensional spherical structure, AGS has high sludge-water separation efficiency, great treatment capacity, and strong tolerance to toxic and harmful substances, so it has been considered to be one of the most promising wastewater treatment technologies. This paper comprehensively reviewed AGS from multiple perspectives over the past two decades, including the culture conditions, granulation mechanisms, metabolic and structural stability, storage, and its diverse applications.

Preparation of electrochemical sensor based on glassy carbon electrode and its specificity and sensitivity for directional detection of antibiotic resistance genes spreading in the water environment.

Antibiotic-resistant bacteria/resistance genes (ARB/ARGs) have been paid much attention due to the environmental risks they might bring. They were demonstrated to be widespread in surface water and wastewater. Determining the concentrations of ARGs is the first step to evaluate the degree of pollution.

Effect of extrusion-spheronization granulation and manganese loading on catalytic ozonation of petrochemical wastewater.

The petrochemical secondary effluent (PSE) is typical refractory wastewater derived from the petrochemical industries, which requires advanced treatment due to the strict environmental protection policies. Catalytic ozonation is one of the most widely used advanced oxidation technologies in wastewater treatment because of its high mineralization rate, in which the alumina-based catalyst usually plays an important role. Extrusion-spheronization is a promising technique for the preparation of alumina spheres because the synthesized alumina particles have high sphericity, high specific surface aera and narrow particle size distribution.

Effect of carbon source conditions on response of nitrifying sludge to 3,5-dichlorophenol.

Nutritional conditions of activated sludge had a significant influence on nitrification inhibition response. This study comprehensively investigated the inhibition of 3,5-dichlorophenol (3,5-DCP) on nitrification of activated sludge with different C/N ratios and carbon source types. The corresponding extracellular polymeric substances (EPS), microbial communities and functional genes were analysed.

Mutual boost of granulation and enrichment of anammox bacteria in an anaerobic/oxic/anoxic system as the temperature decreases when treating municipal wastewater.

Low temperature is an important factor affecting the municipal wastewater treatment systems. The aim of this study was tracking the variations in the abundance of anammox bacteria (AnAOB) and the sludge form as the temperature decreased. Mutual boost of granulation and enrichment of AnAOB was achieved even though the temperature dropped from 20.