Optimization for container truck routing in container terminal with multi quay cranes considering emissions policy.

In container terminal, the container trucks should go by a "quay crane - container trucks -import and export block" routing, and the optimization of this routing has become the focus of this paper. This study divided the problem of routing optimization into two levels: one is a routing optimization model of single container truck which takes the lowest total cost as the target, without considering the distribution of overall transportation task; the other is a routing optimization model concerning the allocation of no-load trucks, aiming at the lowest cost of transportation task. We designed an improved Particle Swarm Optimization (PSO) algorithm to solve the two-level optimization model, and the influence of emission policy on the two-level optimization model and the influence of the number of container trucks on the transportation distance of level II in optimization model are analyzed.

Neutralizing chimeric heavy-chain antibody targeting the L-HN domain of Clostridium botulinum neurotoxin type F.

Botulinum toxin (BoNT) from Clostridium botulinum is the most toxic biotoxin known and is also an important bioterrorism agent. After poisoning, the only effective treatment is injection of antitoxin. However, neutralizing nanoantibodies are safer and more effective, representing a promising therapeutic approach.

[Retracted] Potentiation of the antitumor activity of adriamycin against osteosarcoma by cannabinoid WIN‑55,212‑2.

[This retracts the article DOI: 10.3892/ol.2015.

Development and comparison of machine learning-based models for predicting heart failure after acute myocardial infarction.

Aims: Heart failure (HF) is one of the common adverse cardiovascular events after acute myocardial infarction (AMI), but the predictive efficacy of numerous machine learning (ML) built models is unclear. This study aimed to build an optimal model to predict the occurrence of HF in AMI patients by comparing seven ML algorithms.

Methods: Cohort 1 included AMI patients from 2018 to 2019 divided into HF and control groups.

Research on low-carbon dual channel supply chain considering product substitution under government carbon tax and low-carbon subsidy.

Since dual channel supply chain has become one of the main modes of supply chain, its research has acquired great significance. This paper constructs a low-carbon dual channel supply chain composed of one manufacturer and one retailer. The manufacturer produces low-carbon product and high carbon product with substitution relationship.

Proteomic profile of Trichinella spiralis infected mice with acute spinal cord injury: A 4D label-free quantitative analysis.

Spinal cord injury (SCI) can cause severe loss of locomotor and sensory activities, with no ideal treatment. Emerging reports suggest that the helminth therapy is highly effective in relieving numerous inflammatory diseases. Proteomic profiling is often used to elucidate the underlying mechanism behind SCI.

Machine learning predicts the risk of hemorrhagic transformation of acute cerebral infarction and in-hospital death.

Background: The incidence of hemorrhagic transformation (HT) during thrombolysis after acute cerebral infarction (ACI) is very high. We aimed to develop a model to predict the occurrence of HT after ACI and the risk of death after HT.

Methods: Cohort 1 is divided into HT and non-HT groups, to train the model and perform internal validation.

First-principles study on the electronic structure and photocatalytic property of a novel two-dimensional ZrS/InSe heterojunction.

Photocatalytic water cracking technology provides a broad prospect for solving the current energy crisis using solar energy and water resources. In this paper, a two-dimensional ZrS/InSe heterojunction for accelerating the process of hydrogen production from water decomposition was constructed, and its electronic structure and photocatalytic property were studied using first-principles calculation. The results show that the lattice mismatch rate of the heterojunction from monolayer ZrS and monolayer InSe is 2.

Selecting and Characterizing Tyrosinase Inhibitors from Rhizoma Based on Spectrum-Activity Relationship and Molecular Docking.

Rhizoma (AMR) is a famous classical Chinese traditional medicine (CTM), which has been used as a tonic for many diseases for thousands of years. In ancient China, it was used as a supplementary food for beauty in the palace. In preliminary studies, the function of whitening skin and the significant inhibiting effect on tyrosinase (TYR) which is the reactive enzyme in the composition of melanin of AMR were discovered, and the relevant research was rarely reported.

Cystatin Alleviates Sepsis Through Activating Regulatory Macrophages.

Multi-organ failure caused by the inflammatory cytokine storm induced by severe infection is the major cause of death for sepsis. -Cys is a cysteine protease inhibitor secreted by with strong immunomodulatory functions on host immune system. Our previous studies have shown that treatment with -Cys recombinant protein (r-Cys) attenuated inflammation caused by sepsis.

Preparation and Properties of Cyanobacteria-Based Carbon Quantum Dots/Polyvinyl Alcohol/ Nanocellulose Composite.

Blue luminescent carbon quantum dots (CQDs) were prepared from cyanobacteria by a hydrothermal method. The PL quantum yields of the obtained CQDs was 5.30%.

Phytochemistry and biological properties of isoprenoid flavonoids from Sophora flavescens Ait.

Sophora flavescens Ait (Ku-Shen in Chinese) is a popular traditional Chinese herbal medicine in China for a long history. It shows significant pharmacological activities in the treatment of dysentery, eczema, fever, jaundice, vulvar swelling, gastrointestinal hemorrhage and inflammatory disorders. Alkaloids and flavonoids have been identified as virtual components, especially isoprenoid flavanonols are a class of characteristic compounds for S.

Preparation of cyanobacteria-enhanced poly(vinyl)alcohol-based films with resistance to blue-violet light / red light and water.

The harmful cyanobacteria blooms which usually form in spring and summer, cause global eutrophication of freshwater and coastal marine ecosystems. This study tried to utilize cyanobacteria as a raw material to produce biological poly(vinyl)alcohol-based films. Cyanobacteria was firstly modified with poly(ethylene glycol), guanidine hydrochloride, carboxymethyl cellulose and 3-glycidoxypropyltrimethoxysilane as plasticizer, modifier, toughening agent and coupling agent, respectively.

Preparation and Performance of Radiata-Pine-Derived Polyvinyl Alcohol/Carbon Quantum Dots Fluorescent Films.

In this study, the low-cost processing residue of Radiata pine (Pinus radiata D. Don) was used as the lone carbon source for synthesis of CQDs (Carbon quantum dots) with a QY (The quantum yield of the CQDs) of 1.60%.

Green Preparation of Fluorescent Carbon Quantum Dots from Cyanobacteria for Biological Imaging.

Biomass-based carbon quantum dots (CQDs) have become a significant carbon materials by their virtues of being cost-effective, easy to fabricate and low in environmental impact. However, there are few reports regarding using cyanobacteria as a carbon source for the synthesis of fluorescent CQDs. In this study, the low-cost biomass of cyanobacteria was used as the sole carbon source to synthesize water-soluble CQDs by a simple hydrothermal method.

Optimization of Graphene Conductive Ink with 73 wt% Graphene Contents.

With the pace of development accelerating in printed electronics, the fabrication and application of conductive ink have been brought into sharp focus in recent years. The discovery of graphene also unfolded a vigorous research campaign. In this paper, we prepared graphene conductive ink and explored the feasibility of applying the ink to flexible paper-based circuit.

Comparison of the efficacy and safety of 3 treatments for patients with osteoporotic vertebral compression fractures: A network meta-analysis.

Background: Osteoporotic vertebral compression fractures (OVCFs) constitute an age-related health problem that affects approximately 200 million people worldwide. Currently, various treatments are performed with the goal of reducing pain, stabilizing the vertebrate, and restoring mobility. In this study, we aimed to assess the efficacy and safety of vertebroplasty (VP), kyphoplasty (KP), and conservative treatment (CT) for the treatment of OVCFs.

Fabrication and Characteristics of Reduced Graphene Oxide Produced with Different Green Reductants.

There has been an upsurge of green reductants for the preparation of graphene materials taking consideration of human health and the environment in recent years. In this paper, reduced graphene oxides (RGOs) were prepared by chemical reduction of graphene oxide (GO) with three green reductants, L-ascorbic acid (L-AA), D-glucose (D-GLC) and tea polyphenol (TP), and comparatively characterized by X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) spectra, Raman spectra and electrical conductivity analysis. Results showed that all these three reductants were effective to remove oxygen-containing functional groups in GO and restore the electrical conductivity of the obtained RGO.

Potentiation of the antitumor activity of adriamycin against osteosarcoma by cannabinoid WIN-55,212-2.

Osteosarcoma is the most frequent primary malignant bone tumor that occurs in children and adolescents. The present study aimed to identify novel therapeutic strategies for osteosarcoma, by assessing the antitumor activity of the cannabinoid WIN-55,212-2 and its combined effect with adriamycin (ADM) against the MG-63 human osteosarcoma cell line. To evaluate the antiproliferative action of these molecules, a Cell Counting kit-8 (CCK-8) assay was used.

MicroRNA-17-5p induces drug resistance and invasion of ovarian carcinoma cells by targeting PTEN signaling.

Background: The miR-17-5p was overexpressed in ovarian cancer cells, and those cells were treated with paclitaxel. The proliferation of ovarian cancer cells was assessed by MTT assay. The Caspase-Glo3/7 and TUNEL assay were used to examine the effect of miR-17-5p on paclitaxel-induced apoptosis in ovarian cancer cells.

Microarray and ChIP-seq data analysis revealed changes in p53-mediated transcriptional regulation in Nutlin-3-treated U2OS cells.

Integrative analysis of chromatin immunoprecipitation-sequencing (ChIP-seq) data and microarray data was performed to illustrate the effect of Nutlin‑3 on promoter selectivity and transcriptional regulation by the tumor suppressor p53 in U2OS human osteosarcoma cells. Raw data (accession number, GSE46642) were downloaded from Gene Expression Omnibus. Differential analyses were performed using package limma of R software.